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Mtres1 mitochondrial transcription rescue factor 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 683897, updated on 27-Nov-2024

Summary

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Official Symbol
Mtres1provided by RGD
Official Full Name
mitochondrial transcription rescue factor 1provided by RGD
Primary source
RGD:1597785
See related
EnsemblRapid:ENSRNOG00000047118 AllianceGenome:RGD:1597785
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable ribosomal large subunit binding activity and tRNA binding activity. Predicted to be involved in regulation of mitochondrial transcription and rescue of stalled ribosome. Predicted to be located in mitochondrial matrix. Predicted to be active in mitochondrion. Orthologous to human MTRES1 (mitochondrial transcription rescue factor 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Muscle (RPKM 274.6), Heart (RPKM 186.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Mtres1 in Genome Data Viewer
Location:
20q13
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (48604479..48622364, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (47022343..47038888, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (48276101..48294975, complement)

Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein L37A, pseudogene 5 Neighboring gene BEN domain containing 3 Neighboring gene fractured callus expressed transcript 1, pseudogene 1 Neighboring gene CD24 molecule

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Quantitative proteomics revealed C6orf203/MTRES1 as a factor preventing stress-induced transcription deficiency in human mitochondria. Kotrys AV, et al. Nucleic Acids Res, 2019 Aug 22. PMID 31226201, Free PMC Article
  2. Phosphoproteome analysis of functional mitochondria isolated from resting human muscle reveals extensive phosphorylation of inner membrane protein complexes and enzymes. Zhao X, et al. Mol Cell Proteomics, 2011 Jan. PMID 20833797, Free PMC Article
  3. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA binding ISO
Inferred from Sequence Orthology
more info
  
enables ribosomal large subunit binding ISO
Inferred from Sequence Orthology
more info
  
enables tRNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in regulation of mitochondrial transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of mitochondrial transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in rescue of stalled ribosome ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in mitochondrial matrix ISO
Inferred from Sequence Orthology
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
mitochondrial transcription rescue factor 1
Names
uncharacterized protein C6orf203 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001109448.1 → NP_001102918.1  mitochondrial transcription rescue factor 1

    See identical proteins and their annotated locations for NP_001102918.1

    Status: PROVISIONAL

    Source sequence(s)
    CH474025
    UniProtKB/TrEMBL
    A0A8I6ARF0, A6K6W9, M0R7R2, Q3B8P7
    Related
    ENSRNOP00000097401.1, ENSRNOT00000097351.2
    Conserved Domains (1) summary
    cl09940
    Location:126 → 228
    S4; S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086038.1 Reference GRCr8

    Range
    48604479..48622364 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006256581.5 → XP_006256643.1  mitochondrial transcription rescue factor 1 isoform X2

    See identical proteins and their annotated locations for XP_006256643.1

    UniProtKB/TrEMBL
    A0A8I6ARF0, A6K6W9, M0R7R2, Q3B8P7
    Conserved Domains (1) summary
    cl09940
    Location:126 → 228
    S4; S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized ...

  2. XM_063279504.1 → XP_063135574.1  mitochondrial transcription rescue factor 1 isoform X1

    UniProtKB/TrEMBL
    A0A8I6A8Y4
    Related
    ENSRNOP00000089834.1, ENSRNOT00000104066.2

  3. XM_039099059.2 → XP_038954987.1  mitochondrial transcription rescue factor 1 isoform X3

    Conserved Domains (1) summary
    cl40612
    Location:131 → 179
    YlmH_RBD; Putative RNA-binding domain in YlmH
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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