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Nup43 nucleoporin 43 [ Rattus norvegicus (Norway rat) ]

Gene ID: 683983, updated on 4-Jan-2025

Summary

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Official Symbol
Nup43provided by RGD
Official Full Name
nucleoporin 43provided by RGD
Primary source
RGD:1596513
See related
EnsemblRapid:ENSRNOG00000049505 AllianceGenome:RGD:1596513
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to be located in cytosol; kinetochore; and nucleus. Predicted to be part of nuclear pore outer ring. Orthologous to human NUP43 (nucleoporin 43). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Thymus (RPKM 77.8), Heart (RPKM 71.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Nup43 in Genome Data Viewer
Location:
1p13
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (3964814..3978277)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (2144427..2157887)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (1771468..1781554)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein L23a, pseudogene 6 Neighboring gene uncharacterized LOC120098770 Neighboring gene LDL receptor related protein 11 Neighboring gene protein-L-isoaspartate (D-aspartate) O-methyltransferase 1 Neighboring gene large tumor suppressor kinase 1 Neighboring gene small ribosomal subunit protein uS12-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Regulation of mRNA trafficking by nuclear pore complexes. Bonnet A, et al. Genes (Basel), 2014 Sep 2. PMID 25184662, Free PMC Article
  2. Cell-cycle-dependent phosphorylation of the nuclear pore Nup107-160 subcomplex. Glavy JS, et al. Proc Natl Acad Sci U S A, 2007 Mar 6. PMID 17360435, Free PMC Article
  3. The entire Nup107-160 complex, including three new members, is targeted as one entity to kinetochores in mitosis. Loïodice I, et al. Mol Biol Cell, 2004 Jul. PMID 15146057, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC187947

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in kinetochore ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear envelope ISO
Inferred from Sequence Orthology
more info
  
part_of nuclear pore outer ring IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of nuclear pore outer ring ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear speck IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
nucleoporin Nup43

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001128191.2 → NP_001121663.1  nucleoporin Nup43 isoform 2

    See identical proteins and their annotated locations for NP_001121663.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A6JP15, M0R9Y3
    Related
    ENSRNOP00000066318.1, ENSRNOT00000073528.4
    Conserved Domains (3) summary
    COG2319
    Location:114 → 294
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:112 → 142
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:112 → 267
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  2. NM_001401290.1 → NP_001388219.1  nucleoporin Nup43 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    B0BNB5
    Related
    ENSRNOP00000071201.1, ENSRNOT00000080138.3
    Conserved Domains (2) summary
    sd00039
    Location:78 → 120
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:73 → 293
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    3964814..3978277
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039090803.2 → XP_038946731.1  nucleoporin Nup43 isoform X1

    Related
    ENSRNOP00000108293.1, ENSRNOT00000142327.1
    Conserved Domains (2) summary
    sd00039
    Location:50 → 92
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:45 → 265
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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Chemical Information
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