G6pc3 glucose 6 phosphatase, catalytic, 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: G6pc3provided by MGI
Official Full Name: glucose 6 phosphatase, catalytic, 3provided by MGI
Primary source: MGI:MGI:1915651
See related: Ensembl:ENSMUSG00000034793 AllianceGenome:MGI:1915651
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: UGRP; 0710001K01Rik
Summary: Enables glucose-6-phosphatase activity. Involved in gluconeogenesis. Acts upstream of or within glucose-6-phosphate transport. Is active in endoplasmic reticulum. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in severe congenital neutropenia 4. Orthologous to human G6PC3 (glucose-6-phosphatase catalytic subunit 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in testis adult (RPKM 154.8), adrenal adult (RPKM 105.5) and 25 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 D; 11 65.79 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (102080525..102084907)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (102189699..102194081)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Survival and differentiation defects contribute to neutropenia in glucose-6-phosphatase-beta (G6PC3) deficiency in a model of mouse neutrophil granulocyte differentiation.
Title: Survival and differentiation defects contribute to neutropenia in glucose-6-phosphatase-β (G6PC3) deficiency in a model of mouse neutrophil granulocyte differentiation.
G-CSF improves G6pc3(-/-) neutrophil survival by modulating apoptotic mediators and rectifies function by enhancing energy homeostasis.
Title: G-CSF improves murine G6PC3-deficient neutrophil function by modulating apoptosis and energy homeostasis.
in nonapoptotic neutrophils, G6PC3 is essential for normal energy homeostasis. A G6PC3 deficiency prevents recycling of ER glucose to the cytoplasm, leading to neutrophil dysfunction
Title: Lack of glucose recycling between endoplasmic reticulum and cytoplasm underlies cellular dysfunction in glucose-6-phosphatase-beta-deficient neutrophils in a congenital neutropenia syndrome.
The absence of G6Pase-beta led to neutropenia
Title: Impaired neutrophil activity and increased susceptibility to bacterial infection in mice lacking glucose-6-phosphatase-beta.
UGRP/G6Pase is the major glucose-6-phosphatase of physiological importance for glucose homeostasis in vivo.
Title: Deletion of the gene encoding the ubiquitously expressed glucose-6-phosphatase catalytic subunit-related protein (UGRP)/glucose-6-phosphatase catalytic subunit-beta results in lowered plasma cholesterol and elevated glucagon.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (3) 1 citation

General gene information

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Markers

ksks317 (e-PCR)
- UniSTS:514361

RH136552 (e-PCR)
- UniSTS:210534

AW545836 (e-PCR)
- UniSTS:180328

AU045429 (e-PCR)
- UniSTS:160169

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables glucose-6-phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glucose-6-phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables glucose-6-phosphatase activity	ISA Inferred from Sequence Alignment more info	PubMed
enables glucose-6-phosphatase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in gluconeogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in gluconeogenesis	IDA Inferred from Direct Assay more info	PubMed
involved_in gluconeogenesis	IEA Inferred from Electronic Annotation more info
involved_in gluconeogenesis	ISO Inferred from Sequence Orthology more info
involved_in glucose 6-phosphate metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in glucose 6-phosphate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in glucose 6-phosphate metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within glucose-6-phosphate transport	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
is_active_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: glucose-6-phosphatase 3

Names: G-6-Pase 3; G6Pase 3; glc-6-Pase-beta; glucose-6-phosphatase catalytic subunit-related; glucose-6-phosphatase-beta; ubiquitous glucose-6-phosphatase catalytic subunit-related protein

NP_787949.2

EC 3.1.3.9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_175935.3 → NP_787949.2 glucose-6-phosphatase 3

See identical proteins and their annotated locations for NP_787949.2

Status: VALIDATED

Source sequence(s)

BC069959

Consensus CDS

CCDS25491.1

UniProtKB/Swiss-Prot

Q3TND0, Q6NSQ9, Q811R8

Related

ENSMUSP00000077995.8, ENSMUST00000078975.8

Conserved Domains (2) summary

COG0671
Location:45 → 185

PgpB; Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]

cd03381
Location:38 → 270

PAP2_glucose_6_phosphatase; PAP2_like proteins, glucose-6-phosphatase subfamily. Glucose-6-phosphatase converts glucose-6-phosphate into free glucose and is active in the lumen of the endoplasmic reticulum, where it is bound to the membrane. The generation of free glucose is an ...