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Dhx34 DExH-box helicase 34 [ Rattus norvegicus (Norway rat) ]

Gene ID: 684903, updated on 2-Nov-2024

Summary

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Official Symbol
Dhx34provided by RGD
Official Full Name
DExH-box helicase 34provided by RGD
Primary source
RGD:1584452
See related
EnsemblRapid:ENSRNOG00000047575 AllianceGenome:RGD:1584452
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable ATP hydrolysis activity; RNA binding activity; and helicase activity. Predicted to be involved in negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; and positive regulation of phosphorylation. Orthologous to human DHX34 (DExH-box helicase 34). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Adrenal (RPKM 44.6), Thymus (RPKM 22.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Dhx34 in Genome Data Viewer
Location:
1q21
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (86009047..86034477, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (76880867..76905148, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (78069260..78112488, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 8 member A2 Neighboring gene Meis homeobox 3 Neighboring gene transmembrane protein 64-like Neighboring gene complement C5a receptor 2 Neighboring gene dynein light chain 1, cytoplasmic-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. DHX34 and NBAS form part of an autoregulatory NMD circuit that regulates endogenous RNA targets in human cells, zebrafish and Caenorhabditis elegans. Longman D, et al. Nucleic Acids Res, 2013 Sep. PMID 23828042, Free PMC Article
  2. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Baltz AG, et al. Mol Cell, 2012 Jun 8. PMID 22681889
  3. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity ISO
Inferred from Sequence Orthology
more info
  
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables helicase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay ISO
Inferred from Sequence Orthology
more info
  
involved_in nuclear-transcribed mRNA catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of phosphorylation ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
probable ATP-dependent RNA helicase DHX34
Names
DEAH (Asp-Glu-Ala-His) box polypeptide 34
DEAH-box helicase 34
NP_001258381.1
XP_038946776.1
XP_038946786.1
XP_038946793.1
XP_038946803.1
XP_038946806.1
XP_063129925.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001271452.1 → NP_001258381.1  probable ATP-dependent RNA helicase DHX34

    See identical proteins and their annotated locations for NP_001258381.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A6J8A0, M0R9X1
    Related
    ENSRNOP00000066304.4, ENSRNOT00000075327.4
    Conserved Domains (2) summary
    COG1643
    Location:155 → 687
    HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]
    pfam07717
    Location:798 → 909
    OB_NTP_bind; Oligonucleotide/oligosaccharide-binding (OB)-fold

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    86009047..86034477 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039090848.2 → XP_038946776.1  probable ATP-dependent RNA helicase DHX34 isoform X1

    UniProtKB/TrEMBL
    A6J8A0, M0R9X1
    Conserved Domains (2) summary
    COG1643
    Location:155 → 687
    HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]
    pfam07717
    Location:798 → 909
    OB_NTP_bind; Oligonucleotide/oligosaccharide-binding (OB)-fold

  2. XM_039090858.2 → XP_038946786.1  probable ATP-dependent RNA helicase DHX34 isoform X1

    UniProtKB/TrEMBL
    A6J8A0, M0R9X1
    Conserved Domains (2) summary
    COG1643
    Location:155 → 687
    HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]
    pfam07717
    Location:798 → 909
    OB_NTP_bind; Oligonucleotide/oligosaccharide-binding (OB)-fold

  3. XM_039090865.2 → XP_038946793.1  probable ATP-dependent RNA helicase DHX34 isoform X1

    UniProtKB/TrEMBL
    A6J8A0, M0R9X1
    Conserved Domains (2) summary
    COG1643
    Location:155 → 687
    HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]
    pfam07717
    Location:798 → 909
    OB_NTP_bind; Oligonucleotide/oligosaccharide-binding (OB)-fold

  4. XM_039090875.2 → XP_038946803.1  probable ATP-dependent RNA helicase DHX34 isoform X2

    Conserved Domains (2) summary
    COG1643
    Location:18 → 468
    HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]
    pfam07717
    Location:579 → 690
    OB_NTP_bind; Oligonucleotide/oligosaccharide-binding (OB)-fold

  5. XM_039090878.2 → XP_038946806.1  probable ATP-dependent RNA helicase DHX34 isoform X4

    Conserved Domains (1) summary
    COG1643
    Location:155 → 587
    HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]

  6. XM_063273855.1 → XP_063129925.1  probable ATP-dependent RNA helicase DHX34 isoform X3

Nucleotide Protein Strain
Heading Accession and Version

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