Atr ATR serine/threonine kinase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Atrprovided by RGD
Official Full Name: ATR serine/threonine kinaseprovided by RGD
Primary source: RGD:1305796
See related: EnsemblRapid:ENSRNOG00000010027 AllianceGenome:RGD:1305796
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable MutLalpha complex binding activity; MutSalpha complex binding activity; and histone H2AXS139 kinase activity. Involved in response to arsenic-containing substance and response to xenobiotic stimulus. Predicted to be located in Golgi apparatus; XY body; and nucleus. Predicted to be part of ATR-ATRIP complex. Predicted to be active in several cellular components, including GABA-ergic synapse; nuclear envelope; and site of DNA damage. Predicted to be extrinsic component of synaptic vesicle membrane. Human ortholog(s) of this gene implicated in Seckel syndrome 1; adenoid cystic carcinoma; colon cancer; lung cancer; and pancreatic cancer. Orthologous to human ATR (ATR serine/threonine kinase). [provided by Alliance of Genome Resources, Jan 2025]
Expression: Biased expression in Testes (RPKM 162.8), Thymus (RPKM 69.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q31

Exon count:: 49

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (105306299..105403742)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (96426704..96524152)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (103673578..103770886)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

data suggest that G1 transit and S-phase entry are critical factors in homocysteine-induced neuronal apoptosis, and the ATM/ATR response may normally function neuroprotectively to prevent or repair inappropriate cell cycle progression
Title: S phase entry causes homocysteine-induced death while ataxia telangiectasia and Rad3 related protein functions anti-apoptotically to protect neurons.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 3-phosphoinositide-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables AMP-activated protein kinase activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables MutLalpha complex binding	ISO Inferred from Sequence Orthology more info
enables MutSalpha complex binding	ISO Inferred from Sequence Orthology more info
enables Rho-dependent protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables eukaryotic translation initiation factor 2alpha kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS1 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS121 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AT120 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXS139 kinase activity	ISO Inferred from Sequence Orthology more info
enables histone H2BS14 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS36 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S10 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S28 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S57 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T11 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T3 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T45 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T6 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H4S1 kinase activity	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	ISO Inferred from Sequence Orthology more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
enables ribosomal protein S6 kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in DNA damage checkpoint signaling	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within DNA damage checkpoint signaling	ISO Inferred from Sequence Orthology more info
involved_in DNA damage checkpoint signaling	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within DNA damage response	ISO Inferred from Sequence Orthology more info
involved_in DNA damage response	ISO Inferred from Sequence Orthology more info
involved_in DNA repair	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within DNA repair	ISO Inferred from Sequence Orthology more info
involved_in cellular response to UV	ISO Inferred from Sequence Orthology more info
involved_in cellular response to gamma radiation	ISO Inferred from Sequence Orthology more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within chromosome organization	ISO Inferred from Sequence Orthology more info
involved_in double-strand break repair	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within embryo implantation	ISO Inferred from Sequence Orthology more info
involved_in establishment of RNA localization to telomere	ISO Inferred from Sequence Orthology more info
involved_in mitotic G2/M transition checkpoint	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA replication	ISO Inferred from Sequence Orthology more info
acts_upstream_of nuclear membrane disassembly	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-serine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA damage response, signal transduction by p53 class mediator	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of telomerase catalytic core complex assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of telomere maintenance via telomerase	ISO Inferred from Sequence Orthology more info
involved_in protein autophosphorylation	ISO Inferred from Sequence Orthology more info
involved_in protein localization to chromosome, telomeric region	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in replication fork processing	ISO Inferred from Sequence Orthology more info
involved_in replicative senescence	ISO Inferred from Sequence Orthology more info
involved_in response to arsenic-containing substance	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to mechanical stimulus	ISO Inferred from Sequence Orthology more info
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in telomere maintenance	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of ATR-ATRIP complex	ISO Inferred from Sequence Orthology more info
is_active_in GABA-ergic synapse	ISO Inferred from Sequence Orthology more info
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in PML body	ISO Inferred from Sequence Orthology more info
located_in XY body	ISO Inferred from Sequence Orthology more info
is_active_in chromosome	IBA Inferred from Biological aspect of Ancestor more info
located_in chromosome	ISO Inferred from Sequence Orthology more info
is_active_in extrinsic component of synaptic vesicle membrane	ISO Inferred from Sequence Orthology more info
located_in male germ cell nucleus	ISO Inferred from Sequence Orthology more info
is_active_in nuclear envelope	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
is_active_in postsynapse	ISO Inferred from Sequence Orthology more info
is_active_in site of DNA damage	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: serine/threonine-protein kinase ATR

Names: ataxia telangiectasia and Rad3 related; ataxia telangiectasia and rad3 related-like

NP_001414096.1

EC 2.7.11.1

XP_006243662.1

EC 2.7.11.1

XP_038938489.1

EC 2.7.11.1

XP_063122216.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001427167.1 → NP_001414096.1 serine/threonine-protein kinase ATR

Status: VALIDATED

Source sequence(s)

JAXUCZ010000008

UniProtKB/TrEMBL

A6I268, D3Z822

Related

ENSRNOP00000043760.5, ENSRNOT00000049967.7

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086026.1 Reference GRCr8

Range

105306299..105403742

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063266146.1 → XP_063122216.1 serine/threonine-protein kinase ATR isoform X2
XM_006243600.5 → XP_006243662.1 serine/threonine-protein kinase ATR isoform X1

See identical proteins and their annotated locations for XP_006243662.1

UniProtKB/TrEMBL

A0A8I6G5M3, A6I268

Conserved Domains (4) summary

smart00802
Location:1054 → 1160

UME; Domain in UVSB PI-3 kinase, MEI-41 and ESR-1

COG5032
Location:2052 → 2570

TEL1; Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms]

cd00892
Location:2219 → 2493

PIKKc_ATR; Catalytic domain of Ataxia telangiectasia and Rad3-related proteins

pfam02259
Location:1700 → 2021

FAT; FAT domain
XM_039082561.2 → XP_038938489.1 serine/threonine-protein kinase ATR isoform X1

UniProtKB/TrEMBL

A0A8I6G5M3, A6I268

Conserved Domains (4) summary

smart00802
Location:1054 → 1160

UME; Domain in UVSB PI-3 kinase, MEI-41 and ESR-1

COG5032
Location:2052 → 2570

TEL1; Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms]

cd00892
Location:2219 → 2493

PIKKc_ATR; Catalytic domain of Ataxia telangiectasia and Rad3-related proteins

pfam02259
Location:1700 → 2021

FAT; FAT domain