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Rpp30 ribonuclease P/MRP subunit p30 [ Rattus norvegicus (Norway rat) ]

Gene ID: 685332, updated on 4-Jan-2025

Summary

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Official Symbol
Rpp30provided by RGD
Official Full Name
ribonuclease P/MRP subunit p30provided by RGD
Primary source
RGD:1595116
See related
EnsemblRapid:ENSRNOG00000018718 AllianceGenome:RGD:1595116
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable ribonuclease P RNA binding activity. Predicted to contribute to ribonuclease P activity. Predicted to be involved in tRNA 5'-leader removal. Predicted to be part of nucleolar ribonuclease P complex and ribonuclease MRP complex. Orthologous to human RPP30 (ribonuclease P/MRP subunit p30). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Heart (RPKM 94.4), Thymus (RPKM 89.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Rpp30 in Genome Data Viewer
Location:
1q53
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (243198647..243221559)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (233786048..233808958)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (254697247..254720093)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA17 Neighboring gene 5-hydroxytryptamine receptor 7 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene uncharacterized LOC134485228 Neighboring gene uncharacterized LOC134485226 Neighboring gene uncharacterized LOC134485227 Neighboring gene ankyrin repeat domain 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Unexpected diversity of RNase P, an ancient tRNA processing enzyme: challenges and prospects. Lai LB, et al. FEBS Lett, 2010 Jan 21. PMID 19931535, Free PMC Article
  2. Differential association of protein subunits with the human RNase MRP and RNase P complexes. Welting TJ, et al. RNA, 2006 Jul. PMID 16723659, Free PMC Article
  3. Cryo-EM Structure of the Human Ribonuclease P Holoenzyme. Wu J, et al. Cell, 2018 Nov 15. PMID 30454648
  4. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Castello A, et al. Cell, 2012 Jun 8. PMID 22658674
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC187977

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ribonuclease P RNA binding ISO
Inferred from Sequence Orthology
more info
  
contributes_to ribonuclease P activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in tRNA 5'-leader removal ISO
Inferred from Sequence Orthology
more info
  
involved_in tRNA processing IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of multimeric ribonuclease P complex ISO
Inferred from Sequence Orthology
more info
  
part_of nucleolar ribonuclease P complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of ribonuclease MRP complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ribonuclease P protein subunit p30
Names
ribonuclease P/MRP 30 subunit
NP_001178012.1
XP_038946870.1
XP_063129955.1
XP_063129956.1
XP_063129957.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001191083.1 → NP_001178012.1  ribonuclease P protein subunit p30

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A0A8I6GJ86, D3ZU51
    Related
    ENSRNOP00000090910.1, ENSRNOT00000097535.2
    Conserved Domains (1) summary
    pfam01876
    Location:21 → 224
    RNase_P_p30; RNase P subunit p30

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    243198647..243221559
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063273887.1 → XP_063129957.1  ribonuclease P protein subunit p30 isoform X4

  2. XM_039090942.2 → XP_038946870.1  ribonuclease P protein subunit p30 isoform X2

    Conserved Domains (1) summary
    pfam01876
    Location:20 → 134
    RNase_P_p30; RNase P subunit p30

  3. XM_063273886.1 → XP_063129956.1  ribonuclease P protein subunit p30 isoform X3

  4. XM_063273885.1 → XP_063129955.1  ribonuclease P protein subunit p30 isoform X1

RNA

  1. XR_005492259.2 RNA Sequence

  2. XR_005492258.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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