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Gcsam germinal center-associated, signaling and motility [ Rattus norvegicus (Norway rat) ]

Gene ID: 685692, updated on 9-Dec-2024

Summary

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Official Symbol
Gcsamprovided by RGD
Official Full Name
germinal center-associated, signaling and motilityprovided by RGD
Primary source
RGD:1591321
See related
EnsemblRapid:ENSRNOG00000022110 AllianceGenome:RGD:1591321
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Gcet2
Summary
Predicted to enable actin binding activity; myosin II binding activity; and protein kinase binding activity. Predicted to be involved in negative regulation of lymphocyte migration and regulation of B cell receptor signaling pathway. Orthologous to human GCSAM (germinal center associated signaling and motility). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in Spleen (RPKM 97.8), Thymus (RPKM 81.5) and 6 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Gcsam in Genome Data Viewer
Location:
11q21
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (68658350..68669598, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (55195757..55207011, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (60168938..60180191, complement)

Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene transmembrane serine protease 7 Neighboring gene similar to human chromosome 3 open reading frame 52 Neighboring gene solute carrier family 9 member C1 Neighboring gene Tnf receptor associated factor 4, pseudogene 1 Neighboring gene CD200 molecule like 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Germinal centre protein HGAL promotes lymphoid hyperplasia and amyloidosis via BCR-mediated Syk activation. Romero-Camarero I, et al. Nat Commun, 2013. PMID 23299888, Free PMC Article
  2. HGAL, a lymphoma prognostic biomarker, interacts with the cytoskeleton and mediates the effects of IL-6 on cell migration. Lu X, et al. Blood, 2007 Dec 15. PMID 17823310, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables actin binding ISO
Inferred from Sequence Orthology
more info
  
enables myosin II binding ISO
Inferred from Sequence Orthology
more info
  
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in negative regulation of lymphocyte migration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of lymphocyte migration ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of B cell receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of B cell receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
germinal center expressed transcript 2; germinal center-associated signaling and motility protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001432441.1 → NP_001419370.1  germinal center expressed transcript 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000011
    UniProtKB/TrEMBL
    D3ZLK1

  2. NM_001432442.1 → NP_001419371.1  germinal center expressed transcript 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000011
    UniProtKB/TrEMBL
    A0A1W2Q6E0, A6IQY4

  3. NM_001432443.1 → NP_001419372.1  germinal center expressed transcript 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000011

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086029.1 Reference GRCr8

    Range
    68658350..68669598 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006248351.5 → XP_006248413.1  germinal center-associated signaling and motility protein isoform X2

    Related
    ENSRNOP00000076218.1, ENSRNOT00000093731.3
    Conserved Domains (1) summary
    pfam15666
    Location:52 → 133
    HGAL; Germinal center-associated lymphoma

  2. XM_001064866.7 → XP_001064866.2  germinal center-associated signaling and motility protein isoform X1

    Related
    ENSRNOP00000041206.1, ENSRNOT00000043020.5
    Conserved Domains (1) summary
    pfam15666
    Location:75 → 156
    HGAL; Germinal center-associated lymphoma

  3. XM_039088890.2 → XP_038944818.1  germinal center-associated signaling and motility protein isoform X3

    Conserved Domains (1) summary
    pfam15666
    Location:28 → 115
    HGAL; Germinal center-associated lymphoma
Nucleotide Protein Strain
Heading Accession and Version

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