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Serhl serine hydrolase-like [ Mus musculus (house mouse) ]

Gene ID: 68607, updated on 27-Nov-2024

Summary

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Official Symbol
Serhlprovided by MGI
Official Full Name
serine hydrolase-likeprovided by MGI
Primary source
MGI:MGI:1890404
See related
Ensembl:ENSMUSG00000058586 AllianceGenome:MGI:1890404
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
0610008B10Rik; 1110019M09Rik
Summary
Predicted to enable hydrolase activity. Located in cytoplasmic vesicle. Is expressed in choroid invagination; diencephalon roof plate; and metencephalon part of 4th ventricle choroid plexus. Orthologous to several human genes including SERHL2 (serine hydrolase like 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in large intestine adult (RPKM 23.5), colon adult (RPKM 16.7) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Serhl in Genome Data Viewer
Location:
15 E1; 15 39.32 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (82984394..83000876)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (83100192..83116676)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene Nfat activating molecule with ITAM motif 1 Neighboring gene STARR-positive B cell enhancer ABC_E7401 Neighboring gene STARR-positive B cell enhancer ABC_E3149 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:82873210-82873393 Neighboring gene predicted gene, 32620 Neighboring gene STARR-seq mESC enhancer starr_39309 Neighboring gene STARR-positive B cell enhancer ABC_E3150 Neighboring gene predicted gene, 41366 Neighboring gene STARR-positive B cell enhancer ABC_E7402 Neighboring gene ribosomal RNA processing 7 homolog A Neighboring gene polymerase (DNA-directed), delta interacting protein 3 Neighboring gene RNA U12, small nuclear

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Identification of Serhl, a new member of the serine hydrolase family induced by passive stretch of skeletal muscle in vivo. Sadusky TJ, et al. Genomics, 2001 Apr 1. PMID 11352564
  2. Functional redundancy of frizzled 3 and frizzled 6 in planar cell polarity control of mouse hair follicles. Dong B, et al. Development, 2018 Oct 8. PMID 30237242, Free PMC Article
  3. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
  4. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
  5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables hydrolase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasmic vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion HDA PubMed 
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in peroxisome ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
serine hydrolase-like protein
Names
SHL

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_023475.3 → NP_075964.1  serine hydrolase-like protein

    See identical proteins and their annotated locations for NP_075964.1

    Status: VALIDATED

    Source sequence(s)
    AK003827, BC064069, BY082798
    Consensus CDS
    CCDS49682.1
    UniProtKB/Swiss-Prot
    Q9DCZ8, Q9EPB5
    UniProtKB/TrEMBL
    Q3U3G8, Q80XK9
    Related
    ENSMUSP00000077345.5, ENSMUST00000078218.11
    Conserved Domains (2) summary
    COG0596
    Location:15 → 303
    MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]
    pfam12695
    Location:28 → 129
    Abhydrolase_5; Alpha/beta hydrolase family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    82984394..83000876
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030248725.2 → XP_030104585.1  serine hydrolase-like protein isoform X1

RNA

  1. XR_384036.4 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9EPB5.1 GenPept UniProtKB/Swiss-Prot:Q9EPB5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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