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Tm2d3 TM2 domain containing 3 [ Mus musculus (house mouse) ]

Gene ID: 68634, updated on 27-Nov-2024

Summary

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Official Symbol
Tm2d3provided by MGI
Official Full Name
TM2 domain containing 3provided by MGI
Primary source
MGI:MGI:1915884
See related
Ensembl:ENSMUSG00000078681 AllianceGenome:MGI:1915884
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Blp2; 1110025I09Rik; 5930422O05Rik
Summary
Predicted to be involved in lateral inhibition. Predicted to be located in membrane. Orthologous to human TM2D3 (TM2 domain containing 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in kidney adult (RPKM 55.3), ovary adult (RPKM 37.2) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Tm2d3 in Genome Data Viewer
Location:
7 C; 7 35.26 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (65343204..65351650)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (65693417..65701913)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene threonyl-tRNA synthetase 3 Neighboring gene predicted gene, 51484 Neighboring gene predicted gene, 33234 Neighboring gene heterogeneous nuclear ribonucleoprotein A3 pseudogene Neighboring gene predicted gene, 51485

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. TM2D3, a mammalian homologue of Drosophila neurogenic gene product Almondex, regulates surface presentation of Notch receptors. Masuda W, et al. Sci Rep, 2023 Nov 27. PMID 38016980, Free PMC Article
  2. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article
  3. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
  4. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
  5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in lateral inhibition IEA
Inferred from Electronic Annotation
more info
  
involved_in lateral inhibition ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
TM2 domain-containing protein 3
Names
BBP-like protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001403392.1 → NP_001390321.1  TM2 domain-containing protein 3 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC122184

  2. NM_001403393.1 → NP_001390322.1  TM2 domain-containing protein 3 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC122184
    UniProtKB/TrEMBL
    A0A0U1RNE7
    Related
    ENSMUSP00000145534.2, ENSMUST00000206517.2

  3. NM_001403394.1 → NP_001390323.1  TM2 domain-containing protein 3 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC122184

  4. NM_001403395.1 → NP_001390324.1  TM2 domain-containing protein 3 isoform 6 precursor

    Status: VALIDATED

    Source sequence(s)
    AC122184

  5. NM_026795.4 → NP_081071.1  TM2 domain-containing protein 3 isoform 1

    See identical proteins and their annotated locations for NP_081071.1

    Status: VALIDATED

    Source sequence(s)
    AC122184
    Consensus CDS
    CCDS21340.1
    UniProtKB/Swiss-Prot
    Q8BJ83
    Related
    ENSMUSP00000032726.8, ENSMUST00000032726.14
    Conserved Domains (1) summary
    pfam05154
    Location:165 → 214
    TM2; TM2 domain

  6. NM_178056.4 → NP_835157.1  TM2 domain-containing protein 3 isoform 2 precursor

    See identical proteins and their annotated locations for NP_835157.1

    Status: VALIDATED

    Source sequence(s)
    AC122184
    Consensus CDS
    CCDS21341.1
    UniProtKB/Swiss-Prot
    Q8BJ83, Q9D156
    Related
    ENSMUSP00000103119.4, ENSMUST00000107495.5
    Conserved Domains (1) summary
    pfam05154
    Location:196 → 245
    TM2; TM2 domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    65343204..65351650
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BJ83.1 GenPept UniProtKB/Swiss-Prot:Q8BJ83

Gene LinkOut

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