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Srrt serrate, RNA effector molecule [ Rattus norvegicus (Norway rat) ]

Gene ID: 686980, updated on 4-Jan-2025

Summary

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Symbol
Srrtprovided by RGD
Full Name
serrate, RNA effector moleculeprovided by RGD
Primary source
RGD:1591241
See related
EnsemblRapid:ENSRNOG00000048277 AllianceGenome:RGD:1591241
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
AABR07035787.1
Summary
Predicted to enable DNA binding activity; mRNA cap binding complex binding activity; and protein-macromolecule adaptor activity. Predicted to be involved in neuronal stem cell population maintenance; positive regulation of neurogenesis; and regulation of gene expression. Predicted to be located in cytoplasm and nucleoplasm. Predicted to be part of ribonucleoprotein complex. Predicted to be active in nuclear body. Orthologous to human SRRT (serrate, RNA effector molecule). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Thymus (RPKM 265.5), Spleen (RPKM 189.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Srrt in Genome Data Viewer
Location:
12q12
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (25027883..25042847)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (19392578..19406098)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (22457898..22471090)

Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 12, member 9 Neighboring gene thyroid hormone receptor interactor 6 Neighboring gene UFM1-specific peptidase 1 Neighboring gene acetylcholinesterase Neighboring gene uncharacterized LOC120095907

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Ars2 maintains neural stem-cell identity through direct transcriptional activation of Sox2. Andreu-Agullo C, et al. Nature, 2011 Dec 25. PMID 22198669, Free PMC Article
  2. Ars2 links the nuclear cap-binding complex to RNA interference and cell proliferation. Gruber JJ, et al. Cell, 2009 Jul 23. PMID 19632182, Free PMC Article
  3. The nuclear cap-binding complex interacts with the U4/U6·U5 tri-snRNP and promotes spliceosome assembly in mammalian cells. Pabis M, et al. RNA, 2013 Aug. PMID 23793891, Free PMC Article
  4. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Baltz AG, et al. Mol Cell, 2012 Jun 8. PMID 22681889
  5. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Castello A, et al. Cell, 2012 Jun 8. PMID 22658674

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables mRNA cap binding complex binding ISO
Inferred from Sequence Orthology
more info
  
enables protein-macromolecule adaptor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in neuronal stem cell population maintenance ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of neurogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in primary miRNA processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in primary miRNA processing ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nuclear body IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  
part_of ribonucleoprotein complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
serrate RNA effector molecule homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001427441.1 → NP_001414370.1  serrate RNA effector molecule homolog

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000012
    Related
    ENSRNOP00000094934.2, ENSRNOT00000113858.2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086030.1 Reference GRCr8

    Range
    25027883..25042847
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039090063.2 → XP_038945991.1  serrate RNA effector molecule homolog isoform X5

    UniProtKB/TrEMBL
    A0A8I6AM26
    Conserved Domains (2) summary
    pfam04959
    Location:645 → 842
    ARS2; Arsenite-resistance protein 2
    pfam12066
    Location:153 → 262
    DUF3546; Domain of unknown function (DUF3546)

  2. XM_039090059.2 → XP_038945987.1  serrate RNA effector molecule homolog isoform X1

    Conserved Domains (2) summary
    pfam04959
    Location:645 → 845
    ARS2; Arsenite-resistance protein 2
    pfam12066
    Location:153 → 262
    DUF3546; Domain of unknown function (DUF3546)

  3. XM_039090060.2 → XP_038945988.1  serrate RNA effector molecule homolog isoform X2

    Conserved Domains (2) summary
    pfam04959
    Location:645 → 838
    ARS2; Arsenite-resistance protein 2
    pfam12066
    Location:153 → 262
    DUF3546; Domain of unknown function (DUF3546)

  4. XM_039090061.1 → XP_038945989.1  serrate RNA effector molecule homolog isoform X3

    Conserved Domains (2) summary
    pfam04959
    Location:548 → 752
    ARS2; Arsenite-resistance protein 2
    pfam12066
    Location:56 → 165
    DUF3546; Domain of unknown function (DUF3546)

  5. XM_039090062.2 → XP_038945990.1  serrate RNA effector molecule homolog isoform X4

    Conserved Domains (2) summary
    pfam04959
    Location:418 → 622
    ARS2; Arsenite-resistance protein 2
    pfam12066
    Location:1 → 35
    DUF3546; Domain of unknown function (DUF3546)
Nucleotide Protein Strain
Heading Accession and Version

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