Foxf1 forkhead box F1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Foxf1provided by RGD
Official Full Name: forkhead box F1provided by RGD
Primary source: RGD:1584229
See related: EnsemblRapid:ENSRNOG00000049906 AllianceGenome:RGD:1584229
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in several processes, including circulatory system development; digestive tract development; and regulation of DNA-templated transcription. Predicted to act upstream of or within several processes, including mesenchyme morphogenesis; regulation of transcription by RNA polymerase II; and respiratory system development. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in persistent fetal circulation syndrome. Orthologous to human FOXF1 (forkhead box F1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Restricted expression toward (RPKM 143.5) See more
Orthologs: human mouse all
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Genomic context

Location:: 19q12

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	19	NC_086037.1 (66062635..66066427)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	19	NC_051354.1 (49153949..49157741)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	19	NC_005118.4 (53012306..53016100)

Chromosome 19 - NC_086037.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Foxf1 gene increases the risk of osteoporosis in rats by inhibiting osteoblast formation and promoting osteoclast differentiation through the upregulation of NF-kappaB pathway.
Title: Foxf1 gene increases the risk of osteoporosis in rats by inhibiting osteoblast formation and promoting osteoclast differentiation through the upregulation of NF-κB pathway.

Submit: New GeneRIF Correction

General gene information

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Markers

Foxf1a (e-PCR), detects polymorphism
- UniSTS:531336

Foxf1a (e-PCR), detects polymorphism
- UniSTS:526994

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables transcription cis-regulatory region binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in animal organ morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within animal organ morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in biological_process	ND No biological Data available more info
involved_in blood vessel development	ISO Inferred from Sequence Orthology more info
involved_in cardiac left ventricle morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell-cell adhesion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular response to cytokine stimulus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular response to organic cyclic compound	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within detection of wounding	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within determination of left/right symmetry	ISO Inferred from Sequence Orthology more info
involved_in digestive tract development	ISO Inferred from Sequence Orthology more info
involved_in ductus arteriosus closure	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within embryonic digestive tract development	ISO Inferred from Sequence Orthology more info
involved_in embryonic digestive tract morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in embryonic ectodermal digestive tract morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within embryonic foregut morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in endocardial cushion development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within epithelial cell differentiation involved in mammary gland alveolus development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within epithelial tube branching involved in lung morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within establishment of epithelial cell apical/basal polarity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within extracellular matrix organization	ISO Inferred from Sequence Orthology more info
involved_in heart development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within in utero embryonic development	ISO Inferred from Sequence Orthology more info
involved_in in utero embryonic development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lateral mesodermal cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lung alveolus development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lung development	ISO Inferred from Sequence Orthology more info
involved_in lung development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lung lobe morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lung morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in lung vasculature development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within mesenchyme migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within mesoderm development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within mesodermal cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in midgut development	ISO Inferred from Sequence Orthology more info
involved_in morphogenesis of a branching structure	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of inflammatory response	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of mast cell degranulation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in pancreas development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of cell migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of cell-substrate adhesion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of mesenchymal cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in respiratory tube development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within right lung morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within smooth muscle cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within smoothened signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within somitogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within trachea development	ISO Inferred from Sequence Orthology more info
involved_in trachea development	ISO Inferred from Sequence Orthology more info
involved_in ureter development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within vasculogenesis	ISO Inferred from Sequence Orthology more info
involved_in venous blood vessel development	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: forkhead box protein F1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.