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Mbtd1 mbt domain containing 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 688133, updated on 27-Nov-2024

Summary

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Official Symbol
Mbtd1provided by RGD
Official Full Name
mbt domain containing 1provided by RGD
Primary source
RGD:1592427
See related
EnsemblRapid:ENSRNOG00000049988 AllianceGenome:RGD:1592427
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable NuA4 histone acetyltransferase complex binding activity; chromatin binding activity; and methylated histone binding activity. Predicted to be involved in double-strand break repair via homologous recombination; regulation of cell cycle; and regulation of nucleobase-containing compound metabolic process. Predicted to act upstream of or within embryonic skeletal system development. Predicted to be located in membrane. Predicted to be part of NuA4 histone acetyltransferase complex and nucleosome. Predicted to be active in nucleus and site of double-strand break. Orthologous to human MBTD1 (mbt domain containing 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 100.2), Kidney (RPKM 77.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Mbtd1 in Genome Data Viewer
Location:
10q26
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (79336041..79392315)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (78839140..78895413)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (81588233..81645532)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene thymosin, beta 10 like 2 Neighboring gene uncharacterized LOC120095281 Neighboring gene UTP18 small subunit processome component Neighboring gene NME/NM23 nucleoside diphosphate kinase 2 Neighboring gene NME/NM23 nucleoside diphosphate kinase 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Hemp, an mbt domain-containing protein, plays essential roles in hematopoietic stem cell function and skeletal formation. Honda H, et al. Proc Natl Acad Sci U S A, 2011 Feb 8. PMID 21252303, Free PMC Article
  2. Structural studies of a four-MBT repeat protein MBTD1. Eryilmaz J, et al. PLoS One, 2009 Oct 20. PMID 19841675, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables NuA4 histone acetyltransferase complex binding ISO
Inferred from Sequence Orthology
more info
  
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables methylated histone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables methylated histone binding ISO
Inferred from Sequence Orthology
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in chromatin organization IEA
Inferred from Electronic Annotation
more info
  
involved_in double-strand break repair via homologous recombination ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within embryonic skeletal system development ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of double-strand break repair via homologous recombination ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of NuA4 histone acetyltransferase complex ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
part_of nucleosome ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in site of double-strand break ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
MBT domain-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001398942.1 → NP_001385871.1  MBT domain-containing protein 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/TrEMBL
    A0A8I5Y128
    Conserved Domains (1) summary
    smart00561
    Location:471 → 563
    MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    79336041..79392315
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039087681.2 → XP_038943609.1  MBT domain-containing protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZNG7
    Conserved Domains (1) summary
    smart00561
    Location:495 → 587
    MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2

  2. XM_063269849.1 → XP_063125919.1  MBT domain-containing protein 1 isoform X7

    Related
    ENSRNOP00000077010.2, ENSRNOT00000109861.2

  3. XM_063269851.1 → XP_063125921.1  MBT domain-containing protein 1 isoform X8

    UniProtKB/TrEMBL
    A0A8I6AAP7

  4. XM_039087697.2 → XP_038943625.1  MBT domain-containing protein 1 isoform X6

    UniProtKB/TrEMBL
    A0A8I5ZNG7
    Conserved Domains (1) summary
    smart00561
    Location:473 → 565
    MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2

  5. XM_039087690.2 → XP_038943618.1  MBT domain-containing protein 1 isoform X6

    UniProtKB/TrEMBL
    A0A8I5ZNG7
    Conserved Domains (1) summary
    smart00561
    Location:473 → 565
    MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2

  6. XM_039087699.2 → XP_038943627.1  MBT domain-containing protein 1 isoform X6

    UniProtKB/TrEMBL
    A0A8I5ZNG7
    Conserved Domains (1) summary
    smart00561
    Location:473 → 565
    MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2

  7. XM_039087696.1 → XP_038943624.1  MBT domain-containing protein 1 isoform X6

    UniProtKB/TrEMBL
    A0A8I5ZNG7
    Conserved Domains (1) summary
    smart00561
    Location:473 → 565
    MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2

  8. XM_039087701.1 → XP_038943629.1  MBT domain-containing protein 1 isoform X6

    UniProtKB/TrEMBL
    A0A8I5ZNG7
    Conserved Domains (1) summary
    smart00561
    Location:473 → 565
    MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2

  9. XM_063269854.1 → XP_063125924.1  MBT domain-containing protein 1 isoform X11

    UniProtKB/TrEMBL
    A0A8I5Y128
    Related
    ENSRNOP00000079891.1, ENSRNOT00000114021.2

  10. XM_039087684.1 → XP_038943612.1  MBT domain-containing protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZNG7
    Conserved Domains (1) summary
    smart00561
    Location:495 → 587
    MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2

  11. XM_063269852.1 → XP_063125922.1  MBT domain-containing protein 1 isoform X8

    UniProtKB/TrEMBL
    A0A8I6AAP7

  12. XM_063269853.1 → XP_063125923.1  MBT domain-containing protein 1 isoform X9

    Related
    ENSRNOP00000066215.4, ENSRNOT00000072783.5

  13. XM_039087687.2 → XP_038943615.1  MBT domain-containing protein 1 isoform X4

    UniProtKB/TrEMBL
    A0A8I5ZNG7
    Conserved Domains (1) summary
    smart00561
    Location:492 → 584
    MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2

  14. XM_039087680.2 → XP_038943608.1  MBT domain-containing protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZNG7
    Conserved Domains (1) summary
    smart00561
    Location:495 → 587
    MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2

  15. XM_039087688.2 → XP_038943616.1  MBT domain-containing protein 1 isoform X5

    UniProtKB/TrEMBL
    A0A8I5ZNG7
    Conserved Domains (1) summary
    smart00561
    Location:490 → 582
    MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2

  16. XM_039087693.2 → XP_038943621.1  MBT domain-containing protein 1 isoform X6

    UniProtKB/TrEMBL
    A0A8I5ZNG7
    Conserved Domains (1) summary
    smart00561
    Location:473 → 565
    MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2

  17. XM_039087689.2 → XP_038943617.1  MBT domain-containing protein 1 isoform X6

    UniProtKB/TrEMBL
    A0A8I5ZNG7
    Conserved Domains (1) summary
    smart00561
    Location:473 → 565
    MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2

  18. XM_039087694.2 → XP_038943622.1  MBT domain-containing protein 1 isoform X6

    UniProtKB/TrEMBL
    A0A8I5ZNG7
    Conserved Domains (1) summary
    smart00561
    Location:473 → 565
    MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2

  19. XM_039087683.2 → XP_038943611.1  MBT domain-containing protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZNG7
    Conserved Domains (1) summary
    smart00561
    Location:495 → 587
    MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2

  20. XM_039087695.2 → XP_038943623.1  MBT domain-containing protein 1 isoform X6

    UniProtKB/TrEMBL
    A0A8I5ZNG7
    Conserved Domains (1) summary
    smart00561
    Location:473 → 565
    MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2

  21. XM_039087685.2 → XP_038943613.1  MBT domain-containing protein 1 isoform X2

    UniProtKB/TrEMBL
    A0A8I5ZNG7
    Conserved Domains (1) summary
    smart00561
    Location:494 → 586
    MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2

  22. XM_039087708.2 → XP_038943636.1  MBT domain-containing protein 1 isoform X12

    UniProtKB/TrEMBL
    M0R9N9
    Conserved Domains (1) summary
    smart00561
    Location:495 → 587
    MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2

  23. XM_039087705.2 → XP_038943633.1  MBT domain-containing protein 1 isoform X10

    UniProtKB/TrEMBL
    A0A8I5ZNG7
    Conserved Domains (1) summary
    smart00561
    Location:490 → 582
    MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2

  24. XM_039087700.2 → XP_038943628.1  MBT domain-containing protein 1 isoform X6

    UniProtKB/TrEMBL
    A0A8I5ZNG7
    Conserved Domains (1) summary
    smart00561
    Location:473 → 565
    MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2

  25. XM_039087682.2 → XP_038943610.1  MBT domain-containing protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZNG7
    Conserved Domains (1) summary
    smart00561
    Location:495 → 587
    MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2

  26. XM_039087691.2 → XP_038943619.1  MBT domain-containing protein 1 isoform X6

    UniProtKB/TrEMBL
    A0A8I5ZNG7
    Conserved Domains (1) summary
    smart00561
    Location:473 → 565
    MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2

  27. XM_039087692.2 → XP_038943620.1  MBT domain-containing protein 1 isoform X6

    UniProtKB/TrEMBL
    A0A8I5ZNG7
    Conserved Domains (1) summary
    smart00561
    Location:473 → 565
    MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2

  28. XM_063269846.1 → XP_063125916.1  MBT domain-containing protein 1 isoform X3

    Related
    ENSRNOP00000089607.2, ENSRNOT00000113570.2

  29. XM_063269850.1 → XP_063125920.1  MBT domain-containing protein 1 isoform X7

  30. XM_063269856.1 → XP_063125926.1  MBT domain-containing protein 1 isoform X13

  31. XM_039087710.1 → XP_038943638.1  MBT domain-containing protein 1 isoform X13

    Conserved Domains (2) summary
    smart00561
    Location:304 → 396
    MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2
    cl17705
    Location:10 → 81
    MBT; mbt repeat
Nucleotide Protein Strain
Heading Accession and Version

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