Foxk2 forkhead box K2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Foxk2provided by MGI
Official Full Name: forkhead box K2provided by MGI
Primary source: MGI:MGI:1916087
See related: Ensembl:ENSMUSG00000039275 AllianceGenome:MGI:1916087
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: ILF; Ilf1; 1110054H05Rik; 5730434B08Rik; 6230415M23Rik
Summary: Enables DNA-binding transcription repressor activity, RNA polymerase II-specific. Involved in several processes, including intracellular glucose homeostasis; negative regulation of autophagy; and regulation of DNA-templated transcription. Located in cytoplasm and nucleus. Is expressed in several structures, including blastocyst; nervous system; reproductive system; and urinary system. Orthologous to human FOXK2 (forkhead box K2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in whole brain E14.5 (RPKM 17.4), ovary adult (RPKM 17.3) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 E2; 11 85.15 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (121150805..121200726)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (121259987..121309900)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

FOXK2 targeting by the SCF-E3 ligase subunit FBXO24 for ubiquitin mediated degradation modulates mitochondrial respiration.
Title: FOXK2 targeting by the SCF-E3 ligase subunit FBXO24 for ubiquitin mediated degradation modulates mitochondrial respiration.
CircHIPK3 regulates pulmonary fibrosis by facilitating glycolysis in miR-30a-3p/FOXK2-dependent manner.
Title: CircHIPK3 regulates pulmonary fibrosis by facilitating glycolysis in miR-30a-3p/FOXK2-dependent manner.
in vitro and in vivo experiments, including studies of primary human cells, show how FOXK1 and/or FOXK2 are likely to act as important regulators that reprogram cellular metabolism to induce aerobic glycolysis
Title: FOXK1 and FOXK2 regulate aerobic glycolysis.
FoxK1/K2 are reciprocally regulated to FoxO1 following insulin stimulation and play a critical role in the control of apoptosis, metabolism and mitochondrial function.
Title: FoxK1 and FoxK2 in insulin regulation of cellular and mitochondrial metabolism.
FoxK2 is required for proliferation and survival.
Title: FoxK2 is required for cellular proliferation and survival.
Foxk1 and Foxk2 are identified as transcriptional repressors of autophagy in muscle cells and fibroblasts.
Title: Foxk proteins repress the initiation of starvation-induced atrophy and autophagy programs.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH140687 (e-PCR)
- UniSTS:222755

Ilf1 (e-PCR), detects polymorphism
- UniSTS:143584

NoName (e-PCR)
- UniSTS:236793

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables magnesium ion binding	ISO Inferred from Sequence Orthology more info
enables magnesium ion binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific DNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables transcription cis-regulatory region binding	ISO Inferred from Sequence Orthology more info
enables transcription cis-regulatory region binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
acts_upstream_of canonical glycolysis	IDA Inferred from Direct Assay more info	PubMed
involved_in intracellular glucose homeostasis	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of autophagy	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of glucose metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to starvation	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: forkhead box protein K2

Names: cellular transcription factor ILF-1; interleukin enhancer-binding factor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001080932.3 → NP_001074401.2 forkhead box protein K2 isoform 1

See identical proteins and their annotated locations for NP_001074401.2

Status: VALIDATED

Source sequence(s)

AL808021, EU882160

Consensus CDS

CCDS36393.2

UniProtKB/Swiss-Prot

A2AN27, B5AZX0, Q3UCQ1

Related

ENSMUSP00000101719.2, ENSMUST00000106113.2

Conserved Domains (2) summary

cd00060
Location:41 → 145

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

pfam00250
Location:249 → 335

Forkhead; Forkhead domain
NM_001363033.1 → NP_001349962.1 forkhead box protein K2 isoform 2

Status: VALIDATED

Source sequence(s)

AK150439, AL808021

Conserved Domains (2) summary

cd00060
Location:41 → 145

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

pfam00250
Location:249 → 334

Forkhead; Forkhead domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

121150805..121200726

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036156941.1 → XP_036012834.1 forkhead box protein K2 isoform X3

Conserved Domains (3) summary

PHA03247
Location:341 → 562

PHA03247; large tegument protein UL36; Provisional

cd00060
Location:41 → 145

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

cd20055
Location:247 → 344

FH_FOXK2; Forkhead (FH) domain found in Forkhead box protein K2 (FOXK2) and similar proteins
XM_036156942.1 → XP_036012835.1 forkhead box protein K2 isoform X6

Conserved Domains (2) summary

cd00060
Location:41 → 145

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

cd20055
Location:247 → 344

FH_FOXK2; Forkhead (FH) domain found in Forkhead box protein K2 (FOXK2) and similar proteins
XM_011249218.2 → XP_011247520.1 forkhead box protein K2 isoform X1

Conserved Domains (4) summary

PHA03247
Location:380 → 683

PHA03247; large tegument protein UL36; Provisional

COG5025
Location:175 → 381

COG5025; Transcription factor of the Forkhead/HNF3 family [Transcription]

cd00060
Location:41 → 124

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

pfam00250
Location:287 → 373

Forkhead; Forkhead domain
XM_011249219.2 → XP_011247521.1 forkhead box protein K2 isoform X2

Conserved Domains (4) summary

PHA03247
Location:380 → 657

PHA03247; large tegument protein UL36; Provisional

COG5025
Location:175 → 381

COG5025; Transcription factor of the Forkhead/HNF3 family [Transcription]

cd00060
Location:41 → 124

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

pfam00250
Location:287 → 373

Forkhead; Forkhead domain
XM_011249220.2 → XP_011247522.1 forkhead box protein K2 isoform X4

Conserved Domains (3) summary

COG5025
Location:175 → 381

COG5025; Transcription factor of the Forkhead/HNF3 family [Transcription]

cd00060
Location:41 → 124

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

pfam00250
Location:287 → 373

Forkhead; Forkhead domain
XM_011249221.2 → XP_011247523.1 forkhead box protein K2 isoform X5

Conserved Domains (3) summary

COG5025
Location:175 → 381

COG5025; Transcription factor of the Forkhead/HNF3 family [Transcription]

cd00060
Location:41 → 124

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

pfam00250
Location:287 → 373

Forkhead; Forkhead domain