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Slc25a28 solute carrier family 25 member 28 [ Rattus norvegicus (Norway rat) ]

Gene ID: 688811, updated on 27-Nov-2024

Summary

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Official Symbol
Slc25a28provided by RGD
Official Full Name
solute carrier family 25 member 28provided by RGD
Primary source
RGD:1584155
See related
EnsemblRapid:ENSRNOG00000016751 AllianceGenome:RGD:1584155
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable ferrous iron transmembrane transporter activity. Predicted to be involved in iron import into the mitochondrion. Predicted to be located in mitochondrion. Predicted to be active in mitochondrial membrane. Orthologous to human SLC25A28 (solute carrier family 25 member 28). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 150.8), Adrenal (RPKM 147.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Slc25a28 in Genome Data Viewer
Location:
1q54
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (252480106..252491365, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (242530877..242542140, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (263420039..263431312, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134485239 Neighboring gene NK2 homeobox 3 Neighboring gene ectonucleoside triphosphate diphosphohydrolase 7 Neighboring gene cytochrome c oxidase assembly homolog COX15

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Regulation of mitochondrial iron import through differential turnover of mitoferrin 1 and mitoferrin 2. Paradkar PN, et al. Mol Cell Biol, 2009 Feb. PMID 19075006, Free PMC Article
  2. Characterization of a putative murine mitochondrial transporter homology of hMRS3/4. Li FY, et al. Mamm Genome, 2002 Jan. PMID 11773964
  3. Abcb10 physically interacts with mitoferrin-1 (Slc25a37) to enhance its stability and function in the erythroid mitochondria. Chen W, et al. Proc Natl Acad Sci U S A, 2009 Sep 22. PMID 19805291, Free PMC Article
  4. Mitoferrin is essential for erythroid iron assimilation. Shaw GC, et al. Nature, 2006 Mar 2. PMID 16511496
  5. Cellular iron uptake, trafficking and metabolism: Key molecules and mechanisms and their roles in disease. Lane DJ, et al. Biochim Biophys Acta, 2015 May. PMID 25661197

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ferrous iron transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ferrous iron transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in iron import into the mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitochondrial membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
mitoferrin-2
Names
solute carrier family 25 (mitochondrial iron transporter), member 28

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001109515.1 → NP_001102985.1  mitoferrin-2

    See identical proteins and their annotated locations for NP_001102985.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473986
    UniProtKB/TrEMBL
    A6JHD3
    Conserved Domains (1) summary
    pfam00153
    Location:71 → 161
    Mito_carr; Mitochondrial carrier protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    252480106..252491365 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006231567.3 → XP_006231629.1  mitoferrin-2 isoform X1

    UniProtKB/TrEMBL
    G3V865
    Related
    ENSRNOP00000022633.3, ENSRNOT00000022633.7
    Conserved Domains (2) summary
    PTZ00168
    Location:75 → 386
    PTZ00168; mitochondrial carrier protein; Provisional
    pfam00153
    Location:71 → 161
    Mito_carr; Mitochondrial carrier protein

  2. XM_039091206.2 → XP_038947134.1  mitoferrin-2 isoform X2

    Conserved Domains (1) summary
    pfam00153
    Location:1 → 66
    Mito_carr; Mitochondrial carrier protein

  3. XM_039091207.2 → XP_038947135.1  mitoferrin-2 isoform X3

    UniProtKB/TrEMBL
    B2RYH0
    Conserved Domains (1) summary
    pfam00153
    Location:71 → 161
    Mito_carr; Mitochondrial carrier protein
Nucleotide Protein Strain
Heading Accession and Version

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