U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Ubac2 ubiquitin associated domain containing 2 [ Mus musculus (house mouse) ]

Gene ID: 68889, updated on 27-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
Ubac2provided by MGI
Official Full Name
ubiquitin associated domain containing 2provided by MGI
Primary source
MGI:MGI:1916139
See related
Ensembl:ENSMUSG00000041765 AllianceGenome:MGI:1916139
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Phgdhl1; 1190008A14Rik
Summary
Involved in negative regulation of canonical Wnt signaling pathway. Predicted to be located in endoplasmic reticulum. Orthologous to human UBAC2 (UBA domain containing 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in duodenum adult (RPKM 38.1), testis adult (RPKM 37.6) and 28 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Ubac2 in Genome Data Viewer
Location:
14 E5; 14 65.78 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (122115970..122258447)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (121878559..122021035)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene dedicator of cytokinesis 9 Neighboring gene STARR-positive B cell enhancer ABC_E7355 Neighboring gene STARR-positive B cell enhancer mm9_chr14:122197085-122197385 Neighboring gene STARR-positive B cell enhancer mm9_chr14:122197667-122197968 Neighboring gene STARR-positive B cell enhancer mm9_chr14:122223986-122224286 Neighboring gene STARR-seq mESC enhancer starr_37739 Neighboring gene RIKEN cDNA 1810041H14 gene Neighboring gene STARR-positive B cell enhancer ABC_E10843 Neighboring gene STARR-positive B cell enhancer mm9_chr14:122277628-122277929 Neighboring gene STARR-positive B cell enhancer ABC_E9906 Neighboring gene predicted gene 9395 Neighboring gene STARR-positive B cell enhancer ABC_E11585 Neighboring gene STARR-positive B cell enhancer mm9_chr14:122306628-122306928 Neighboring gene STARR-positive B cell enhancer mm9_chr14:122309024-122309325 Neighboring gene STARR-positive B cell enhancer ABC_E7358 Neighboring gene STARR-positive B cell enhancer mm9_chr14:122327665-122327966 Neighboring gene STARR-positive B cell enhancer ABC_E8579 Neighboring gene STARR-positive B cell enhancer mm9_chr14:122337770-122338071 Neighboring gene predicted gene, 46485 Neighboring gene STARR-positive B cell enhancer mm9_chr14:122364300-122364601 Neighboring gene G protein-coupled receptor 18 Neighboring gene G protein-coupled receptor 183 Neighboring gene STARR-positive B cell enhancer ABC_E8580 Neighboring gene STARR-positive B cell enhancer ABC_E4126 Neighboring gene STARR-positive B cell enhancer ABC_E4127 Neighboring gene STARR-positive B cell enhancer ABC_E8581 Neighboring gene predicted gene, 52103 Neighboring gene translocase of inner mitochondrial membrane 8A2 Neighboring gene STARR-positive B cell enhancer ABC_E5466 Neighboring gene RIKEN cDNA A330035P11 gene Neighboring gene STARR-positive B cell enhancer ABC_E5467 Neighboring gene transmembrane 9 superfamily member 2

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Mutagenesis of diploid mammalian genes by gene entrapment. Lin Q, et al. Nucleic Acids Res, 2006. PMID 17062627, Free PMC Article
  2. New roles for the de-ubiquitylating enzyme OTUD4 in an RNA-protein network and RNA granules. Das R, et al. J Cell Sci, 2019 Jun 17. PMID 31138677, Free PMC Article
  3. An Interaction Landscape of Ubiquitin Signaling. Zhang X, et al. Mol Cell, 2017 Mar 2. PMID 28190767
  4. LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling. Choi JH, et al. Science, 2019 May 10. PMID 31073040, Free PMC Article
  5. Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function. Zhang T, et al. Sci Rep, 2017 Apr 5. PMID 28378742, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables serine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of retrograde protein transport, ER to cytosol IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of retrograde protein transport, ER to cytosol ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein localization to endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
ubiquitin-associated domain-containing protein 2
Names
UBA domain-containing protein 2
phosphoglycerate dehydrogenase like 1
phosphoglycerate dehydrogenase-like protein 1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_026861.2 → NP_081137.2  ubiquitin-associated domain-containing protein 2 precursor

    See identical proteins and their annotated locations for NP_081137.2

    Status: VALIDATED

    Source sequence(s)
    AK049109, BC017635, BY080555
    Consensus CDS
    CCDS37019.1
    UniProtKB/Swiss-Prot
    Q3TWC0, Q8R1K1
    Related
    ENSMUSP00000043245.6, ENSMUST00000039803.7
    Conserved Domains (1) summary
    cd14305
    Location:306 → 343
    UBA_UBAC2; UBA domain found in ubiquitin-associated domain-containing protein 2 (UBAC2) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    122115970..122258447
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006519492.4 → XP_006519555.1  ubiquitin-associated domain-containing protein 2 isoform X1

    Conserved Domains (1) summary
    cd14305
    Location:290 → 327
    UBA_UBAC2; UBA domain found in ubiquitin-associated domain-containing protein 2 (UBAC2) and similar proteins

  2. XM_030247988.2 → XP_030103848.1  ubiquitin-associated domain-containing protein 2 isoform X2

    Conserved Domains (2) summary
    cd14305
    Location:123 → 160
    UBA_UBAC2; UBA domain found in ubiquitin-associated domain-containing protein 2 (UBAC2) and similar proteins
    TIGR00601
    Location:62 → 162
    rad23; UV excision repair protein Rad23

RNA

  1. XR_004938442.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8R1K1.1 GenPept UniProtKB/Swiss-Prot:Q8R1K1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools