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Tbpl1 TATA-box binding protein like 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 689030, updated on 27-Nov-2024

Summary

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Official Symbol
Tbpl1provided by RGD
Official Full Name
TATA-box binding protein like 1provided by RGD
Primary source
RGD:1597456
See related
EnsemblRapid:ENSRNOG00000066988 AllianceGenome:RGD:1597456
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable RNA polymerase II core promoter sequence-specific DNA binding activity and RNA polymerase II general transcription initiation factor activity. Predicted to be involved in DNA-templated transcription initiation. Predicted to act upstream of or within acrosome assembly; dTTP biosynthetic process; and spermatid nucleus differentiation. Predicted to be located in cytoplasm and male germ cell nucleus. Predicted to be part of transcription factor TFIIA complex. Orthologous to human TBPL1 (TATA-box binding protein like 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Testes (RPKM 443.4), Brain (RPKM 197.5) and 9 other tissues See more
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Genomic context

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See Tbpl1 in Genome Data Viewer
Location:
1p12
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (24597028..24622445)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (22777892..22803305)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (23977154..24002512)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene transcription factor 21 Neighboring gene uncharacterized LOC120098885 Neighboring gene solute carrier family 2 member 12 Neighboring gene uncharacterized LOC102555830

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Involvement of reactive oxygen species and TATA box-binding protein-related factor 2 in testicular torsion/detorsion-induced injury. Wei SM, et al. Urology, 2013 Feb. PMID 23374846
  2. Distinct functions of TBP and TLF/TRF2 during spermatogenesis: requirement of TLF for heterochromatic chromocenter formation in haploid round spermatids. Martianov I, et al. Development, 2002 Feb. PMID 11861477
  3. TIPT, a male germ cell-specific partner of TRF2, is chromatin-associated and interacts with HP1. Brancorsini S, et al. Cell Cycle, 2008 May 15. PMID 18418073
  4. TATA-binding protein (TBP)-like factor (TLF) is a functional regulator of transcription: reciprocal regulation of the neurofibromatosis type 1 and c-fos genes by TLF/TRF2 and TBP. Chong JA, et al. Mol Cell Biol, 2005 Apr. PMID 15767669, Free PMC Article
  5. Changes in intranuclear chromatin architecture induce bipolar nuclear localization of histone variant H1T2 in male haploid spermatids. Catena R, et al. Dev Biol, 2006 Aug 1. PMID 16765935

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These findings have indicated that overproduction of reactive oxygen species after testicular torsion-detorsion can damage testicular spermatogenesis by downregulation of TRF2 expression.
    Title: Involvement of reactive oxygen species and TATA box-binding protein-related factor 2 in testicular torsion/detorsion-induced injury.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables RNA polymerase II core promoter sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables RNA polymerase II general transcription initiation factor activity ISO
Inferred from Sequence Orthology
more info
  
enables general transcription initiation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in DNA-templated transcription initiation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within acrosome assembly ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within dTTP biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within spermatid nucleus differentiation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within spermatogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in male germ cell nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of transcription factor TFIIA complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
TATA box-binding protein-like 1
Names
TATA box-binding protein-like protein 1
TBP-like 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001127201.1 → NP_001120673.1  TATA box-binding protein-like 1

    See identical proteins and their annotated locations for NP_001120673.1

    Status: VALIDATED

    Source sequence(s)
    AW434020, BF414163, CF109177
    UniProtKB/TrEMBL
    A0A8I6A122
    Conserved Domains (1) summary
    cd04517
    Location:9 → 180
    TLF; TBP-like factors (TLF; also called TLP, TRF, TRP), which are found in most metazoans. TLFs and TBPs have well-conserved core domains; however, they only share about 60% similarity. TLFs, like TBPs, interact with TFIIA and TFIIB, which are part of the ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    24597028..24622445
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063274478.1 → XP_063130548.1  TATA box-binding protein-like 1 isoform X1

  2. XM_063274508.1 → XP_063130578.1  TATA box-binding protein-like 1 isoform X5

  3. XM_063274545.1 → XP_063130615.1  TATA box-binding protein-like 1 isoform X9

  4. XM_063274480.1 → XP_063130550.1  TATA box-binding protein-like 1 isoform X3

    UniProtKB/TrEMBL
    A0A8I6AM51
    Related
    ENSRNOP00000094712.1, ENSRNOT00000115485.2

  5. XM_063274511.1 → XP_063130581.1  TATA box-binding protein-like 1 isoform X7

    UniProtKB/TrEMBL
    A0A8I6A122

  6. XM_039091317.1 → XP_038947245.1  TATA box-binding protein-like 1 isoform X8

    Conserved Domains (1) summary
    cl08263
    Location:1 → 164
    TBP_TLF; TATA box binding protein (TBP): Present in archaea and eukaryotes, TBPs are transcription factors that recognize promoters and initiate transcription. TBP has been shown to be an essential component of three different transcription initiation complexes: ...

  7. XM_063274492.1 → XP_063130562.1  TATA box-binding protein-like 1 isoform X3

    UniProtKB/TrEMBL
    A0A8I6AM51

  8. XM_063274495.1 → XP_063130565.1  TATA box-binding protein-like 1 isoform X3

    UniProtKB/TrEMBL
    A0A8I6AM51

  9. XM_039091288.2 → XP_038947216.1  TATA box-binding protein-like 1 isoform X2

    Conserved Domains (1) summary
    cd04517
    Location:41 → 232
    TLF; TBP-like factors (TLF; also called TLP, TRF, TRP), which are found in most metazoans. TLFs and TBPs have well-conserved core domains; however, they only share about 60% similarity. TLFs, like TBPs, interact with TFIIA and TFIIB, which are part of the ...

  10. XM_039091312.2 → XP_038947240.1  TATA box-binding protein-like 1 isoform X6

    Conserved Domains (1) summary
    cd04517
    Location:41 → 200
    TLF; TBP-like factors (TLF; also called TLP, TRF, TRP), which are found in most metazoans. TLFs and TBPs have well-conserved core domains; however, they only share about 60% similarity. TLFs, like TBPs, interact with TFIIA and TFIIB, which are part of the ...

  11. XM_039091315.1 → XP_038947243.1  TATA box-binding protein-like 1 isoform X7

    UniProtKB/TrEMBL
    A0A8I6A122
    Conserved Domains (1) summary
    cd04517
    Location:9 → 180
    TLF; TBP-like factors (TLF; also called TLP, TRF, TRP), which are found in most metazoans. TLFs and TBPs have well-conserved core domains; however, they only share about 60% similarity. TLFs, like TBPs, interact with TFIIA and TFIIB, which are part of the ...

  12. XM_063274512.1 → XP_063130582.1  TATA box-binding protein-like 1 isoform X7

    UniProtKB/TrEMBL
    A0A8I6A122
    Related
    ENSRNOP00000084884.1, ENSRNOT00000116875.2

  13. XM_063274513.1 → XP_063130583.1  TATA box-binding protein-like 1 isoform X7

    UniProtKB/TrEMBL
    A0A8I6A122

  14. XM_017589742.2 → XP_017445231.1  TATA box-binding protein-like 1 isoform X4

    Related
    ENSRNOP00000014805.6, ENSRNOT00000014805.9
    Conserved Domains (1) summary
    cd04517
    Location:9 → 212
    TLF; TBP-like factors (TLF; also called TLP, TRF, TRP), which are found in most metazoans. TLFs and TBPs have well-conserved core domains; however, they only share about 60% similarity. TLFs, like TBPs, interact with TFIIA and TFIIB, which are part of the ...

  15. XM_063274520.1 → XP_063130590.1  TATA box-binding protein-like 1 isoform X7

    UniProtKB/TrEMBL
    A0A8I6A122

  16. XM_063274486.1 → XP_063130556.1  TATA box-binding protein-like 1 isoform X3

    UniProtKB/TrEMBL
    A0A8I6AM51
Nucleotide Protein Strain
Heading Accession and Version

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