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Cyb5rl cytochrome b5 reductase-like [ Rattus norvegicus (Norway rat) ]

Gene ID: 689035, updated on 4-Jan-2025

Summary

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Official Symbol
Cyb5rlprovided by RGD
Official Full Name
cytochrome b5 reductase-likeprovided by RGD
Primary source
RGD:1597451
See related
EnsemblRapid:ENSRNOG00000009148 AllianceGenome:RGD:1597451
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable cytochrome-b5 reductase activity, acting on NAD(P)H. Predicted to be located in nucleoplasm. Orthologous to human CYB5RL (cytochrome b5 reductase like). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Thymus (RPKM 187.0), Heart (RPKM 24.6) and 6 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Cyb5rl in Genome Data Viewer
Location:
5q34
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (127075034..127097551)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (121846223..121868287)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (126666934..126683069)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene single stranded DNA binding protein 3 Neighboring gene uncharacterized LOC134479027 Neighboring gene mitochondrial ribosomal protein L37 Neighboring gene uncharacterized LOC120102947 Neighboring gene ribosomal protein L28, pseudogene 1 Neighboring gene CUB domain containing protein 2 Neighboring gene transcription elongation factor A N-terminal and central domain containing 2 Neighboring gene transfer RNA alanine (anticodon AGC) 38

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables cytochrome-b5 reductase activity, acting on NAD(P)H IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
cytochrome b5 reductase-like
Names
NADH-cytochrome b5 reductase-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001411873.1 → NP_001398802.1  cytochrome b5 reductase-like

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    Related
    ENSRNOP00000104550.1, ENSRNOT00000130338.1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    127075034..127097551
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063288433.1 → XP_063144503.1  cytochrome b5 reductase-like isoform X4

  2. XM_063288431.1 → XP_063144501.1  cytochrome b5 reductase-like isoform X2

  3. XM_063288434.1 → XP_063144504.1  cytochrome b5 reductase-like isoform X5

  4. XM_039111133.2 → XP_038967061.1  cytochrome b5 reductase-like isoform X6

    UniProtKB/TrEMBL
    A0A8I6A4C4, A6JYQ2
    Conserved Domains (2) summary
    cd06183
    Location:82 → 273
    cyt_b5_reduct_like; Cytochrome b5 reductase catalyzes the reduction of 2 molecules of cytochrome b5 using NADH as an electron donor. Like ferredoxin reductases, these proteins have an N-terminal FAD binding subdomain and a C-terminal NADH binding subdomain, separated by a ...
    pfam09791
    Location:16 → 51
    Oxidored-like; Oxidoreductase-like protein, N-terminal

  5. XM_063288435.1 → XP_063144505.1  cytochrome b5 reductase-like isoform X7

    UniProtKB/TrEMBL
    A6JYQ3

  6. XM_039111134.2 → XP_038967062.1  cytochrome b5 reductase-like isoform X8

    UniProtKB/TrEMBL
    A6JYQ2
    Related
    ENSRNOP00000037061.6, ENSRNOT00000036072.9
    Conserved Domains (2) summary
    cd06183
    Location:82 → 248
    cyt_b5_reduct_like; Cytochrome b5 reductase catalyzes the reduction of 2 molecules of cytochrome b5 using NADH as an electron donor. Like ferredoxin reductases, these proteins have an N-terminal FAD binding subdomain and a C-terminal NADH binding subdomain, separated by a ...
    pfam09791
    Location:16 → 51
    Oxidored-like; Oxidoreductase-like protein, N-terminal

  7. XM_039111129.2 → XP_038967057.1  cytochrome b5 reductase-like isoform X1

    Conserved Domains (2) summary
    cd06183
    Location:82 → 257
    cyt_b5_reduct_like; Cytochrome b5 reductase catalyzes the reduction of 2 molecules of cytochrome b5 using NADH as an electron donor. Like ferredoxin reductases, these proteins have an N-terminal FAD binding subdomain and a C-terminal NADH binding subdomain, separated by a ...
    pfam09791
    Location:16 → 51
    Oxidored-like; Oxidoreductase-like protein, N-terminal

  8. XM_039111132.2 → XP_038967060.1  cytochrome b5 reductase-like isoform X3

    Conserved Domains (2) summary
    cd06183
    Location:82 → 315
    cyt_b5_reduct_like; Cytochrome b5 reductase catalyzes the reduction of 2 molecules of cytochrome b5 using NADH as an electron donor. Like ferredoxin reductases, these proteins have an N-terminal FAD binding subdomain and a C-terminal NADH binding subdomain, separated by a ...
    pfam09791
    Location:16 → 51
    Oxidored-like; Oxidoreductase-like protein, N-terminal

  9. XM_039111130.2 → XP_038967058.1  cytochrome b5 reductase-like isoform X1

    Conserved Domains (2) summary
    cd06183
    Location:82 → 257
    cyt_b5_reduct_like; Cytochrome b5 reductase catalyzes the reduction of 2 molecules of cytochrome b5 using NADH as an electron donor. Like ferredoxin reductases, these proteins have an N-terminal FAD binding subdomain and a C-terminal NADH binding subdomain, separated by a ...
    pfam09791
    Location:16 → 51
    Oxidored-like; Oxidoreductase-like protein, N-terminal

  10. XM_063288436.1 → XP_063144506.1  cytochrome b5 reductase-like isoform X7

    UniProtKB/TrEMBL
    A6JYQ3

  11. XM_039111131.2 → XP_038967059.1  cytochrome b5 reductase-like isoform X1

    Conserved Domains (2) summary
    cd06183
    Location:82 → 257
    cyt_b5_reduct_like; Cytochrome b5 reductase catalyzes the reduction of 2 molecules of cytochrome b5 using NADH as an electron donor. Like ferredoxin reductases, these proteins have an N-terminal FAD binding subdomain and a C-terminal NADH binding subdomain, separated by a ...
    pfam09791
    Location:16 → 51
    Oxidored-like; Oxidoreductase-like protein, N-terminal

  12. XM_063288430.1 → XP_063144500.1  cytochrome b5 reductase-like isoform X1

Nucleotide Protein Strain
Heading Accession and Version

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