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Magohb mago homolog B, exon junction complex subunit [ Rattus norvegicus (Norway rat) ]

Gene ID: 690303, updated on 27-Nov-2024

Summary

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Official Symbol
Magohbprovided by RGD
Official Full Name
mago homolog B, exon junction complex subunitprovided by RGD
Primary source
RGD:1597384
See related
EnsemblRapid:ENSRNOG00000010316 AllianceGenome:RGD:1597384
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to be involved in mRNA splicing, via spliceosome and nuclear-transcribed mRNA catabolic process, nonsense-mediated decay. Located in neuronal cell body. Orthologous to human MAGOHB (mago homolog B, exon junction complex subunit). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Spleen (RPKM 60.3), Thymus (RPKM 37.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Magohb in Genome Data Viewer
Location:
4q42
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (166765558..166773406, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (165034131..165041977, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (165514584..165522366, complement)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene killer cell lectin-like receptor, subfamily A, member 2 Neighboring gene uncharacterized LOC108350878 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene serine/threonine/tyrosine kinase 1 Neighboring gene small nucleolar RNA SNORA70 Neighboring gene Y box binding protein 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. An Atomic Structure of the Human Spliceosome. Zhang X, et al. Cell, 2017 May 18. PMID 28502770
  2. Two mammalian MAGOH genes contribute to exon junction complex composition and nonsense-mediated decay. Singh KK, et al. RNA Biol, 2013 Aug. PMID 23917022, Free PMC Article
  3. The ever-increasing complexities of the exon junction complex. Tange TØ, et al. Curr Opin Cell Biol, 2004 Jun. PMID 15145352
  4. The mammalian RNA-binding protein Staufen2 links nuclear and cytoplasmic RNA processing pathways in neurons. Monshausen M, et al. Neuromolecular Med, 2004. PMID 15970630
  5. Structure of a human catalytic step I spliceosome. Zhan X, et al. Science, 2018 Feb 2. PMID 29301961

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in RNA splicing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in biological_process ND
No biological Data available
more info
  
involved_in mRNA splicing, via spliceosome ISO
Inferred from Sequence Orthology
more info
  
involved_in mRNA transport IEA
Inferred from Electronic Annotation
more info
  
involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of U2-type catalytic step 1 spliceosome ISO
Inferred from Sequence Orthology
more info
  
part_of U2-type precatalytic spliceosome ISO
Inferred from Sequence Orthology
more info
  
part_of catalytic step 2 spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of exon-exon junction complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of exon-exon junction complex ISO
Inferred from Sequence Orthology
more info
  
part_of exon-exon junction subcomplex mago-y14 ISO
Inferred from Sequence Orthology
more info
  
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
protein mago nashi homolog 2
Names
mago homolog B, exon junction complex core component
mago-nashi homolog B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001191105.1 → NP_001178034.1  protein mago nashi homolog 2

    See identical proteins and their annotated locations for NP_001178034.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000004
    UniProtKB/TrEMBL
    A6IM92, F1M0X6
    Related
    ENSRNOP00000063195.2, ENSRNOT00000064420.5
    Conserved Domains (1) summary
    cd11295
    Location:6 → 148
    Mago_nashi; Mago nashi proteins, integral members of the exon junction complex

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    166765558..166773406 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008763424.4 → XP_008761646.1  protein mago nashi homolog 2 isoform X1

    See identical proteins and their annotated locations for XP_008761646.1

    UniProtKB/TrEMBL
    A6IM94
    Conserved Domains (1) summary
    cl03715
    Location:1 → 102
    Mago_nashi; Mago nashi proteins, integral members of the exon junction complex

RNA

  1. XR_005503315.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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