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Tmem258 transmembrane protein 258 [ Mus musculus (house mouse) ]

Gene ID: 69038, updated on 27-Nov-2024

Summary

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Official Symbol
Tmem258provided by MGI
Official Full Name
transmembrane protein 258provided by MGI
Primary source
MGI:MGI:1916288
See related
Ensembl:ENSMUSG00000036372 AllianceGenome:MGI:1916288
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1810006K21Rik
Summary
Enables oligosaccharyltransferase complex binding activity. Acts upstream of or within several processes, including epithelial cell apoptotic process; protein N-linked glycosylation; and response to endoplasmic reticulum stress. Predicted to be located in endoplasmic reticulum and membrane. Predicted to be part of oligosaccharyltransferase complex. Is expressed in several structures, including genitourinary system; heart; liver; lung; and spleen. Orthologous to human TMEM258 (transmembrane protein 258). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in testis adult (RPKM 111.7), placenta adult (RPKM 60.9) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Tmem258 in Genome Data Viewer
Location:
19 A; 19 6.54 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (10181566..10185188)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (10204202..10207824)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene vesicle-associated membrane protein 3 pseudogene Neighboring gene fatty acid desaturase 1 Neighboring gene microRNA 6993 Neighboring gene STARR-positive B cell enhancer ABC_E11020 Neighboring gene flap structure specific endonuclease 1 Neighboring gene myelin regulatory factor Neighboring gene diacylglycerol lipase, alpha Neighboring gene STARR-seq mESC enhancer starr_45549 Neighboring gene predicted gene, 30042

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Structure and transcription promoter activity of mouse flap endonuclease 1 gene: alternative splicing and bidirectional promoter. Emoto M, et al. Gene, 2005 Aug 29. PMID 15967598
  2. TMEM258 Is a Component of the Oligosaccharyltransferase Complex Controlling ER Stress and Intestinal Inflammation. Graham DB, et al. Cell Rep, 2016 Dec 13. PMID 27974209, Free PMC Article
  3. Cryo-electron microscopy structures of human oligosaccharyltransferase complexes OST-A and OST-B. Ramírez AS, et al. Science, 2019 Dec 13. PMID 31831667
  4. Widespread and dynamic translational control of red blood cell development. Alvarez-Dominguez JR, et al. Blood, 2017 Feb 2. PMID 27899360, Free PMC Article
  5. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (2)  1 citation

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables oligosaccharyltransferase complex binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within epithelial cell apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within inflammatory response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within protein N-linked glycosylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein N-linked glycosylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein N-linked glycosylation NAS
Non-traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within protein secretion ISO
Inferred from Sequence Orthology
more info
 PubMed 
acts_upstream_of_or_within response to endoplasmic reticulum stress IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in endoplasmic reticulum membrane NAS
Non-traceable Author Statement
more info
 PubMed 
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
located_in membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of oligosaccharyltransferase complex ISO
Inferred from Sequence Orthology
more info
  
part_of oligosaccharyltransferase complex NAS
Non-traceable Author Statement
more info
 PubMed 
part_of protein-containing complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
transmembrane protein 258
Names
UPF0197 transmembrane protein C11orf10 homolog
dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit TMEM258
oligosaccharyl transferase subunit TMEM258

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163431.1 → NP_001156903.1  transmembrane protein 258 isoform 2

    See identical proteins and their annotated locations for NP_001156903.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents use of an alternate promoter and 5' UTR, and uses a downstream start codon, compared to variant 1. The resulting isoform (2) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC132148, AV456553, BC058335
    Consensus CDS
    CCDS50386.1
    UniProtKB/TrEMBL
    E9Q853
    Related
    ENSMUSP00000128883.2, ENSMUST00000166412.2
    Conserved Domains (1) summary
    pfam05251
    Location:2 → 74
    Ost5; Oligosaccharyltransferase subunit 5

  2. NM_026919.1 → NP_081195.1  transmembrane protein 258 isoform 1

    See identical proteins and their annotated locations for NP_081195.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK007351, AV456553, BB568308
    Consensus CDS
    CCDS50385.1
    UniProtKB/Swiss-Prot
    P61166
    UniProtKB/TrEMBL
    Q60FD1
    Related
    ENSMUSP00000044751.8, ENSMUST00000040372.14
    Conserved Domains (1) summary
    pfam05251
    Location:7 → 79
    Ost5; Oligosaccharyltransferase subunit 5

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    10181566..10185188
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P61166.1 GenPept UniProtKB/Swiss-Prot:P61166

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