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Ddx19b DEAD-box helicase 19B [ Rattus norvegicus (Norway rat) ]

Gene ID: 690693, updated on 27-Nov-2024

Summary

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Official Symbol
Ddx19bprovided by RGD
Official Full Name
DEAD-box helicase 19Bprovided by RGD
Primary source
RGD:1593382
See related
EnsemblRapid:ENSRNOG00000064019 AllianceGenome:RGD:1593382
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Zd10a
Summary
Predicted to enable RNA helicase activity and mRNA binding activity. Predicted to be involved in poly(A)+ mRNA export from nucleus. Predicted to be located in nuclear envelope. Predicted to be active in cytoplasmic stress granule and nucleus. Orthologous to several human genes including DDX19B (DEAD-box helicase 19B). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Kidney (RPKM 186.1), Thymus (RPKM 121.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ddx19b in Genome Data Viewer
Location:
19q12
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (55877567..55910134, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (38968215..38998907, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (43217199..43246196)

Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene ST3 beta-galactoside alpha-2,3-sialyltransferase 2 Neighboring gene DEAD-box helicase 19A Neighboring gene alanyl-tRNA synthetase 1 Neighboring gene transfer RNA glycine (anticodon GCC) 11 Neighboring gene heterogeneous nuclear ribonucleoprotein C like 1 Neighboring gene exosome component 6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Differentially expressed genes execute zinc-induced apoptosis in precancerous esophageal epithelium of zinc-deficient rats. Ishii H, et al. Oncogene, 2004 Oct 21. PMID 15361827
  2. Postage for the messenger: designating routes for nuclear mRNA export. Natalizio BJ, et al. Trends Cell Biol, 2013 Aug. PMID 23583578, Free PMC Article
  3. Large-scale proteomics and phosphoproteomics of urinary exosomes. Gonzales PA, et al. J Am Soc Nephrol, 2009 Feb. PMID 19056867, Free PMC Article
  4. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA helicase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in poly(A)+ mRNA export from nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasmic stress granule IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nuclear envelope ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ATP-dependent RNA helicase DDX19B
Names
DEAD (Asp-Glu-Ala-As) box polypeptide 19B
DEAD (Asp-Glu-Ala-Asp) box polypeptide 19B
zinc responsive protein ZD10B
zinc responsive protein Zd10A
NP_001005895.3
XP_008770756.1
XP_038953928.1
XP_063134361.1
XP_063134362.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001005895.4 → NP_001005895.3  ATP-dependent RNA helicase DDX19B

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000019
    UniProtKB/TrEMBL
    Q5XLP8
    Related
    ENSRNOP00000069097.2, ENSRNOT00000084462.3
    Conserved Domains (2) summary
    cd18787
    Location:307 → 443
    SF2_C_DEAD; C-terminal helicase domain of the DEAD box helicases
    cl28899
    Location:75 → 303
    DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086037.1 Reference GRCr8

    Range
    55877567..55910134 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063278292.1 → XP_063134362.1  ATP-dependent RNA helicase DDX19B isoform X2

  2. XM_039098000.2 → XP_038953928.1  ATP-dependent RNA helicase DDX19B isoform X2

    UniProtKB/TrEMBL
    A0A0G2JY21
    Conserved Domains (2) summary
    cd18787
    Location:198 → 334
    SF2_C_DEAD; C-terminal helicase domain of the DEAD box helicases
    cl28899
    Location:1 → 187
    DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily

  3. XM_008772534.3 → XP_008770756.1  ATP-dependent RNA helicase DDX19B isoform X1

    UniProtKB/TrEMBL
    A0A8I6ADW1, A0A8I6GAE6
    Related
    ENSRNOP00000083150.1, ENSRNOT00000118121.2
    Conserved Domains (3) summary
    PTZ00424
    Location:104 → 482
    PTZ00424; helicase 45; Provisional
    cd00079
    Location:320 → 455
    HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
    cd00268
    Location:107 → 309
    DEADc; DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif ...

  4. XM_063278291.1 → XP_063134361.1  ATP-dependent RNA helicase DDX19B isoform X2

Nucleotide Protein Strain
Heading Accession and Version

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