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Ints13 integrator complex subunit 13 [ Rattus norvegicus (Norway rat) ]

Gene ID: 690728, updated on 27-Nov-2024

Summary

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Official Symbol
Ints13provided by RGD
Official Full Name
integrator complex subunit 13provided by RGD
Primary source
RGD:1592236
See related
EnsemblRapid:ENSRNOG00000001808 AllianceGenome:RGD:1592236
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Asun
Summary
Predicted to be involved in centrosome localization and regulation of mitotic cell cycle. Predicted to act upstream of or within mitotic spindle organization and protein localization to nuclear envelope. Predicted to be located in cytoplasm and nuclear body. Predicted to be part of integrator complex. Orthologous to human INTS13 (integrator complex subunit 13). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 236.0), Heart (RPKM 163.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ints13 in Genome Data Viewer
Location:
4q44
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (181190438..181222235, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (179459740..179491541, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (180854988..180887095, complement)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene inositol 1,4,5-trisphosphate receptor, type 2 Neighboring gene uncharacterized LOC134486658 Neighboring gene uncharacterized LOC134486659 Neighboring gene E3 SUMO-protein ligase NSE2-like Neighboring gene FGFR1 oncogene partner 2 Neighboring gene transmembrane 7 superfamily member 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Human Asunder promotes dynein recruitment and centrosomal tethering to the nucleus at mitotic entry. Jodoin JN, et al. Mol Biol Cell, 2012 Dec. PMID 23097494, Free PMC Article
  2. Drosophila genome-scale screen for PAN GU kinase substrates identifies Mat89Bb as a cell cycle regulator. Lee LA, et al. Dev Cell, 2005 Mar. PMID 15737938
  3. Nuclear-localized Asunder regulates cytoplasmic dynein localization via its role in the integrator complex. Jodoin JN, et al. Mol Biol Cell, 2013 Sep. PMID 23904267, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in centrosome localization IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within centrosome localization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within mitotic spindle organization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein localization to nuclear envelope ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
part_of integrator complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of integrator complex ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear body IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
integrator complex subunit 13
Names
asunder, spermatogenesis regulator homolog (Drosphila)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001109608.1 → NP_001103078.1  integrator complex subunit 13 isoform 2

    See identical proteins and their annotated locations for NP_001103078.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473964
    UniProtKB/TrEMBL
    A6IN19, D4A6N9
    Conserved Domains (1) summary
    pfam10221
    Location:7 → 690
    DUF2151; Cell cycle and development regulator

  2. NM_001398932.1 → NP_001385861.1  integrator complex subunit 13 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000004
    Related
    ENSRNOP00000061847.3, ENSRNOT00000065730.3
    Conserved Domains (1) summary
    pfam10221
    Location:4 → 692
    DUF2151; Cell cycle and development regulator

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    181190438..181222235 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039108388.2 → XP_038964316.1  integrator complex subunit 13 isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZWB2, A6IN18, D4A6N9
    Related
    ENSRNOP00000083691.1, ENSRNOT00000118399.2
    Conserved Domains (1) summary
    pfam10221
    Location:4 → 692
    DUF2151; Cell cycle and development regulator

  2. XM_063286723.1 → XP_063142793.1  integrator complex subunit 13 isoform X2

RNA

  1. XR_005503317.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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