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Mtarc1 mitochondrial amidoxime reducing component 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 690745, updated on 4-Jan-2025

Summary

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Official Symbol
Mtarc1provided by RGD
Official Full Name
mitochondrial amidoxime reducing component 1provided by RGD
Primary source
RGD:1592219
See related
EnsemblRapid:ENSRNOG00000037850 AllianceGenome:RGD:1592219
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Marc1; Mosc1
Summary
Predicted to enable molybdenum ion binding activity; molybdopterin cofactor binding activity; and oxidoreductase activity, acting on other nitrogenous compounds as donors. Predicted to contribute to nitrite reductase (NO-forming) activity. Predicted to be involved in cellular detoxification of nitrogen compound; nitrate metabolic process; and nitric oxide biosynthetic process. Predicted to be located in mitochondrion. Predicted to be part of nitric-oxide synthase complex. Orthologous to human MTARC1 (mitochondrial amidoxime reducing component 1). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Liver (RPKM 730.7), Kidney (RPKM 188.6) and 2 other tissues See more
Orthologs
human all
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Genomic context

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See Mtarc1 in Genome Data Viewer
Location:
13q26
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (98854235..98894208, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (96324377..96362677, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (102693679..102724120, complement)

Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120096339 Neighboring gene H2.0-like homeobox Neighboring gene uncharacterized LOC134481538 Neighboring gene mitochondrial amidoxime reducing component 2 Neighboring gene similar to human chromosome 1 open reading frame 115

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Crystal structure of human mARC1 reveals its exceptional position among eukaryotic molybdenum enzymes. Kubitza C, et al. Proc Natl Acad Sci U S A, 2018 Nov 20. PMID 30397129, Free PMC Article
  2. Biochemical and spectroscopic characterization of the human mitochondrial amidoxime reducing components hmARC-1 and hmARC-2 suggests the existence of a new molybdenum enzyme family in eukaryotes. Wahl B, et al. J Biol Chem, 2010 Nov 26. PMID 20861021, Free PMC Article
  3. Proteomic analysis of the mouse liver mitochondrial inner membrane. Da Cruz S, et al. J Biol Chem, 2003 Oct 17. PMID 12865426
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables molybdenum ion binding ISO
Inferred from Sequence Orthology
more info
  
enables molybdopterin cofactor binding ISO
Inferred from Sequence Orthology
more info
  
enables nitrate reductase activity ISO
Inferred from Sequence Orthology
more info
  
contributes_to nitrite reductase (NO-forming) activity ISO
Inferred from Sequence Orthology
more info
  
enables nitrite reductase activity ISO
Inferred from Sequence Orthology
more info
  
enables oxidoreductase activity, acting on other nitrogenous compounds as donors ISO
Inferred from Sequence Orthology
more info
  
enables pyridoxal phosphate binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cellular detoxification of nitrogen compound ISO
Inferred from Sequence Orthology
more info
  
involved_in nitrate metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in nitric oxide biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
part_of nitric-oxide synthase complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
mitochondrial amidoxime-reducing component 1
Names
MOCO sulphurase C-terminal domain containing 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001100811.1 → NP_001094281.1  mitochondrial amidoxime-reducing component 1

    See identical proteins and their annotated locations for NP_001094281.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000013
    UniProtKB/TrEMBL
    A6JGP5, D3Z900, G3V6I4
    Related
    ENSRNOP00000034963.6, ENSRNOT00000029439.8
    Conserved Domains (3) summary
    COG3217
    Location:60 → 339
    YcbX; Uncharacterized conserved protein YcbX, contains MOSC and Fe-S domains [General function prediction only]
    pfam03473
    Location:207 → 336
    MOSC; MOSC domain
    pfam03476
    Location:58 → 179
    MOSC_N; MOSC N-terminal beta barrel domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086031.1 Reference GRCr8

    Range
    98854235..98894208 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039091110.2 → XP_038947038.1  mitochondrial amidoxime-reducing component 1 isoform X2

    UniProtKB/TrEMBL
    A6JGP6
    Conserved Domains (1) summary
    COG3217
    Location:60 → 299
    YcbX; Uncharacterized conserved protein YcbX, contains MOSC and Fe-S domains [General function prediction only]

  2. XM_063272629.1 → XP_063128699.1  mitochondrial amidoxime-reducing component 1 isoform X1

    UniProtKB/TrEMBL
    A6JGP6
Nucleotide Protein Strain
Heading Accession and Version

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