Cdc42se2 CDC42 small effector 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cdc42se2provided by RGD
Official Full Name: CDC42 small effector 2provided by RGD
Primary source: RGD:1563924
See related: EnsemblRapid:ENSRNOG00000042449 AllianceGenome:RGD:1563924
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1563924
Summary: Predicted to enable signaling adaptor activity. Predicted to be involved in regulation of signal transduction. Predicted to be located in several cellular components, including cell projection; cytoskeleton; and phagocytic cup. Predicted to be active in plasma membrane. Orthologous to human CDC42SE2 (CDC42 small effector 2). [provided by Alliance of Genome Resources, Jan 2025]
Expression: Biased expression in Spleen (RPKM 264.8), Thymus (RPKM 246.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q22

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (39337269..39405772, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (38836549..38905056, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (40054393..40122915, complement)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH139144 (e-PCR)
- UniSTS:221230

RH124288 (e-PCR)
- UniSTS:161110

RH129055 (e-PCR)
- UniSTS:212363

RH136619 (e-PCR)
- UniSTS:210599

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables signaling adaptor activity	ISO Inferred from Sequence Orthology more info
enables small GTPase binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in phagocytosis	IEA Inferred from Electronic Annotation more info
involved_in regulation of Rho protein signal transduction	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell shape	IEA Inferred from Electronic Annotation more info
involved_in regulation of signal transduction	ISO Inferred from Sequence Orthology more info
involved_in regulation of signal transduction	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in phagocytic cup	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: CDC42 small effector protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001126089.2 → NP_001119561.1 CDC42 small effector protein 2

See identical proteins and their annotated locations for NP_001119561.1

Status: VALIDATED

Source sequence(s)

BC129107

UniProtKB/Swiss-Prot

A1L1K4, B5DFF3

UniProtKB/TrEMBL

A6HEI3, V9GZ87

Related

ENSRNOP00000061001.4, ENSRNOT00000063891.4

Conserved Domains (1) summary

cd00132
Location:27 → 67

CRIB; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...