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Immp1l inner mitochondrial membrane peptidase subunit 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 691145, updated on 27-Nov-2024

Summary

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Official Symbol
Immp1lprovided by RGD
Official Full Name
inner mitochondrial membrane peptidase subunit 1provided by RGD
Primary source
RGD:1587441
See related
EnsemblRapid:ENSRNOG00000004829 AllianceGenome:RGD:1587441
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable serine-type endopeptidase activity. Predicted to be involved in protein processing involved in protein targeting to mitochondrion. Predicted to be located in mitochondrion. Predicted to be part of mitochondrial inner membrane peptidase complex. Orthologous to human IMMP1L (inner mitochondrial membrane peptidase subunit 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Muscle (RPKM 220.8), Heart (RPKM 195.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Immp1l in Genome Data Viewer
Location:
3q33
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (112840015..112904297)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (92385329..92449559)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (95955126..96024316)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene paired box 6 Neighboring gene elongator acetyltransferase complex subunit 4 Neighboring gene ribosomal protein L35A like 6 Neighboring gene uncharacterized LOC120101618 Neighboring gene U2 spliceosomal RNA Neighboring gene DnaJ heat shock protein family (Hsp40) member C24 Neighboring gene doublecortin domain containing 1, pseudogene 1 Neighboring gene doublecortin domain containing 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Processing of mitochondrial presequences. Mossmann D, et al. Biochim Biophys Acta, 2012 Sep-Oct. PMID 22172993
  2. Mature DIABLO/Smac is produced by the IMP protease complex on the mitochondrial inner membrane. Burri L, et al. Mol Biol Cell, 2005 Jun. PMID 15814844, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in protein processing involved in protein targeting to mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in signal peptide processing IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of mitochondrial inner membrane peptidase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
mitochondrial inner membrane protease subunit 1
Names
IMP1 inner mitochondrial membrane peptidase-like
NP_001386571.1
NP_001386572.1
XP_006234731.1
XP_063140663.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001399642.1 → NP_001386571.1  mitochondrial inner membrane protease subunit 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/TrEMBL
    A6HNX8, D3ZWF3
    Related
    ENSRNOP00000077722.2, ENSRNOT00000100315.2

  2. NM_001399643.1 → NP_001386572.1  mitochondrial inner membrane protease subunit 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/TrEMBL
    A6HNX8, D3ZWF3
    Related
    ENSRNOP00000006406.5, ENSRNOT00000006406.8

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    112840015..112904297
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006234669.5 → XP_006234731.1  mitochondrial inner membrane protease subunit 1 isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZKD1
    Conserved Domains (2) summary
    cd06530
    Location:33 → 141
    S26_SPase_I; The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are ...
    TIGR02227
    Location:29 → 144
    sigpep_I_bact; signal peptidase I, bacterial type

  2. XM_063284593.1 → XP_063140663.1  mitochondrial inner membrane protease subunit 1 isoform X1

    Related
    ENSRNOP00000101047.1, ENSRNOT00000125771.1
Nucleotide Protein Strain
Heading Accession and Version

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