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Draxin dorsal inhibitory axon guidance protein [ Rattus norvegicus (Norway rat) ]

Gene ID: 691317, updated on 9-Dec-2024

Summary

Official Symbol
Draxinprovided by RGD
Official Full Name
dorsal inhibitory axon guidance proteinprovided by RGD
Primary source
RGD:1585098
See related
EnsemblRapid:ENSRNOG00000077899 AllianceGenome:RGD:1585098
Gene type
protein coding
RefSeq status
MODEL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable molecular adaptor activity. Predicted to be involved in negative regulation of canonical Wnt signaling pathway; negative regulation of neuron projection development; and nervous system development. Predicted to act upstream of or within negative regulation of axon extension and negative regulation of hippocampal neuron apoptotic process. Predicted to be active in extracellular region. Orthologous to human DRAXIN (dorsal inhibitory axon guidance protein). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in Testes (RPKM 6.0), Brain (RPKM 5.5) and 6 other tissues See more
Orthologs
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Genomic context

See Draxin in Genome Data Viewer
Location:
5q36
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (163813308..163846609, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (158530149..158563457, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (164913085..164943012, complement)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene angiotensin II receptor-associated protein Neighboring gene uncharacterized LOC102551534 Neighboring gene uncharacterized LOC102551596 Neighboring gene ribosomal protein L35A, pseudogene 7 Neighboring gene mitotic arrest deficient 2 like 2 Neighboring gene F-box protein 6

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

General gene information

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in Wnt signaling pathway  
involved_in anterior commissure morphogenesis  
involved_in axon guidance  
involved_in axon guidance  
involved_in commissural neuron differentiation in spinal cord  
involved_in commissural neuron differentiation in spinal cord  
involved_in dorsal spinal cord development  
involved_in dorsal spinal cord development  
involved_in forebrain development  
involved_in forebrain development  
acts_upstream_of hippocampal neuron apoptotic process  
acts_upstream_of_or_within negative regulation of axon extension  
involved_in negative regulation of canonical Wnt signaling pathway  
involved_in negative regulation of canonical Wnt signaling pathway  
acts_upstream_of_or_within negative regulation of hippocampal neuron apoptotic process  
involved_in negative regulation of neuron projection development  
acts_upstream_of neuron apoptotic process  
Component Evidence Code Pubs
is_active_in extracellular region  
located_in extracellular region  

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    163813308..163846609 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006239423.5XP_006239485.1  draxin isoform X2

    See identical proteins and their annotated locations for XP_006239485.1

    UniProtKB/TrEMBL
    A6IU48, D3ZDG4
    Related
    ENSRNOP00000112195.1, ENSRNOT00000149539.1
    Conserved Domains (1) summary
    pfam15550
    Location:37342
    Draxin; Draxin
  2. XM_039111355.2XP_038967283.1  draxin isoform X1

    UniProtKB/TrEMBL
    A6IU48
    Related
    ENSRNOP00000101863.1, ENSRNOT00000167890.1
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