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Plekha4 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 [ Mus musculus (house mouse) ]

Gene ID: 69217, updated on 27-Nov-2024

Summary

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Official Symbol
Plekha4provided by MGI
Official Full Name
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4provided by MGI
Primary source
MGI:MGI:1916467
See related
Ensembl:ENSMUSG00000040428 AllianceGenome:MGI:1916467
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pepp1; 2410005C22Rik
Summary
Predicted to enable identical protein binding activity; phosphatidylinositol phosphate binding activity; and phosphatidylinositol-3,4-bisphosphate binding activity. Predicted to be involved in positive regulation of Wnt signaling pathway, planar cell polarity pathway and positive regulation of canonical Wnt signaling pathway. Predicted to be located in cytoplasm and membrane. Predicted to be extrinsic component of cytoplasmic side of plasma membrane. Is expressed in foregut; naris; nervous system; respiratory system cartilage; and turbinate bone primordium. Orthologous to human PLEKHA4 (pleckstrin homology domain containing A4). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in mammary gland adult (RPKM 7.9), ovary adult (RPKM 6.5) and 24 other tissues See more
Orthologs
human all
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Genomic context

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See Plekha4 in Genome Data Viewer
Location:
7 B3; 7 29.34 cM
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (45175754..45203653)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (45526330..45554229)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene TUB like protein 2 Neighboring gene nucleobindin 1 Neighboring gene STARR-positive B cell enhancer ABC_E2239 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:52781513-52781717 Neighboring gene protein phosphatase 1, regulatory subunit 15A Neighboring gene predicted gene, 53387 Neighboring gene hydroxysteroid (17-beta) dehydrogenase 14 Neighboring gene STARR-seq mESC enhancer starr_18846 Neighboring gene RIKEN cDNA 0610005C13 gene Neighboring gene STARR-positive B cell enhancer ABC_E3717 Neighboring gene branched chain aminotransferase 2, mitochondrial

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. USP7 represses lineage differentiation genes in mouse embryonic stem cells by both catalytic and noncatalytic activities. Liu C, et al. Sci Adv, 2023 May 19. PMID 37196079, Free PMC Article
  2. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  3. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
  4. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
  5. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables lipid binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol-3,4-bisphosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol-3,4-bisphosphate binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylinositol-3,5-bisphosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol-3,5-bisphosphate binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylinositol-3-phosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol-3-phosphate binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylinositol-4,5-bisphosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol-4,5-bisphosphate binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in positive regulation of Wnt signaling pathway, planar cell polarity pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of Wnt signaling pathway, planar cell polarity pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in extrinsic component of cytoplasmic side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extrinsic component of cytoplasmic side of plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
pleckstrin homology domain-containing family A member 4
Names
PEPP-1
PH domain-containing family A member 4
phosphoinositol 3-phosphate binding protein-1
pleckstrin homology domain-containing, family A member 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001381849.1 → NP_001368778.1  pleckstrin homology domain-containing family A member 4

    Status: VALIDATED

    Source sequence(s)
    AC151602
    UniProtKB/TrEMBL
    D3YTU1, D3Z3Y7
    Related
    ENSMUSP00000148229.2, ENSMUST00000209517.3
    Conserved Domains (2) summary
    COG1196
    Location:359 → 471
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd13248
    Location:49 → 152
    PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain

  2. NM_148927.2 → NP_683729.2  pleckstrin homology domain-containing family A member 4

    See identical proteins and their annotated locations for NP_683729.2

    Status: VALIDATED

    Source sequence(s)
    AC151602, AV480955, BE652135, BG081030, BY235943, CO044801
    Consensus CDS
    CCDS52248.1
    UniProtKB/TrEMBL
    D3YTU1, D3Z3Y7
    Related
    ENSMUSP00000051468.9, ENSMUST00000051810.15
    Conserved Domains (2) summary
    COG1196
    Location:359 → 471
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd13248
    Location:49 → 152
    PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    45175754..45203653
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006541158.3 → XP_006541221.1  pleckstrin homology domain-containing family A member 4 isoform X1

    Conserved Domains (3) summary
    PHA03247
    Location:276 → 812
    PHA03247; large tegument protein UL36; Provisional
    COG1196
    Location:411 → 523
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd13248
    Location:101 → 204
    PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain

  2. XM_006541166.5 → XP_006541229.1  pleckstrin homology domain-containing family A member 4 isoform X7

    UniProtKB/TrEMBL
    A0A1B0GSM9
    Conserved Domains (2) summary
    COG1196
    Location:411 → 523
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd13248
    Location:101 → 204
    PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain

  3. XM_006541165.4 → XP_006541228.1  pleckstrin homology domain-containing family A member 4 isoform X6

    UniProtKB/TrEMBL
    A0A1B0GSC3
    Related
    ENSMUSP00000147878.2, ENSMUST00000211155.2
    Conserved Domains (2) summary
    COG1196
    Location:411 → 523
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd13248
    Location:101 → 204
    PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain

  4. XM_006541164.5 → XP_006541227.1  pleckstrin homology domain-containing family A member 4 isoform X5

    Conserved Domains (2) summary
    COG1196
    Location:411 → 523
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd13248
    Location:101 → 204
    PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain

  5. XM_006541160.4 → XP_006541223.1  pleckstrin homology domain-containing family A member 4 isoform X2

    Conserved Domains (3) summary
    PHA03247
    Location:276 → 796
    PHA03247; large tegument protein UL36; Provisional
    cd13248
    Location:101 → 204
    PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
    TIGR02169
    Location:377 → 516
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

  6. XM_036153416.1 → XP_036009309.1  pleckstrin homology domain-containing family A member 4 isoform X3

    Conserved Domains (2) summary
    COG1196
    Location:374 → 486
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd13248
    Location:64 → 167
    PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain

  7. XM_006541163.3 → XP_006541226.1  pleckstrin homology domain-containing family A member 4 isoform X4

    See identical proteins and their annotated locations for XP_006541226.1

    UniProtKB/TrEMBL
    D3YTU1, D3Z3Y7
    Conserved Domains (2) summary
    COG1196
    Location:359 → 471
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd13248
    Location:49 → 152
    PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain

  8. XM_017312284.2 → XP_017167773.1  pleckstrin homology domain-containing family A member 4 isoform X8

    Conserved Domains (1) summary
    COG1196
    Location:227 → 339
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

RNA

  1. XR_004934185.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8VC98.1 GenPept UniProtKB/Swiss-Prot:Q8VC98

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