Slc44a4 solute carrier family 44, member 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Slc44a4provided by MGI
Official Full Name: solute carrier family 44, member 4provided by MGI
Primary source: MGI:MGI:1917379
See related: Ensembl:ENSMUSG00000007034 AllianceGenome:MGI:1917379
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: NG22; mTPPT1; 2210409B01Rik
Summary: Enables thiamine pyrophosphate transmembrane transporter activity. Involved in thiamine pyrophosphate transmembrane transport. Predicted to be located in apical plasma membrane. Predicted to be active in plasma membrane. Is expressed in embryo. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 72. Orthologous to human SLC44A4 (solute carrier family 44 member 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in colon adult (RPKM 156.0), large intestine adult (RPKM 85.0) and 6 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 B1; 17 18.46 cM

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (35133200..35149412)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (34914224..34930436)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Effect of knocking out mouse Slc44a4 on colonic uptake of the microbiota-generated thiamine pyrophosphate and colon physiology.
Title: Effect of knocking out mouse Slc44a4 on colonic uptake of the microbiota-generated thiamine pyrophosphate and colon physiology.
epigenetic mechanisms (histone modifications) play a role in determining the tissue-specific pattern of expression of the TPPT along the GI tract.
Title: Mechanism(S) Involved in the Colon-Specific Expression of the Thiamine Pyrophosphate (Tpp) Transporter.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (5) 1 citation

General gene information

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Markers

Slc44a4 (e-PCR), detects polymorphism
- UniSTS:547114

D17Ertd710e (e-PCR), detects polymorphism
- UniSTS:167224

NoName (e-PCR)
- UniSTS:237636

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables antiporter activity	IEA Inferred from Electronic Annotation more info
enables choline transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables choline transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables thiamine pyrophosphate transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables thiamine pyrophosphate transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables thiamine pyrophosphate transmembrane transporter activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in acetylcholine biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in acetylcholine biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in acetylcholine secretion	ISO Inferred from Sequence Orthology more info
involved_in acetylcholine secretion	ISS Inferred from Sequence or Structural Similarity more info
involved_in choline transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in choline transport	ISO Inferred from Sequence Orthology more info
involved_in choline transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in neuromast hair cell development	ISS Inferred from Sequence or Structural Similarity more info
involved_in otolith formation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cell growth	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell growth	ISS Inferred from Sequence or Structural Similarity more info
involved_in thiamine pyrophosphate transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in thiamine pyrophosphate transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in thiamine pyrophosphate transmembrane transport	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in apical plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: choline transporter-like protein 4

Names: thiamine pyrophosphate transporter 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.