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Cd2bp2 CD2 cytoplasmic tail binding protein 2 [ Mus musculus (house mouse) ]

Gene ID: 70233, updated on 27-Nov-2024

Summary

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Official Symbol
Cd2bp2provided by MGI
Official Full Name
CD2 cytoplasmic tail binding protein 2provided by MGI
Primary source
MGI:MGI:1917483
See related
Ensembl:ENSMUSG00000042502 AllianceGenome:MGI:1917483
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1500011B02Rik; 2410024K20Rik
Summary
Predicted to enable ribonucleoprotein complex binding activity. Predicted to be involved in RNA splicing and mRNA processing. Predicted to be located in cytosol; fibrillar center; and nucleoplasm. Predicted to be part of U5 snRNP. Predicted to colocalize with nuclear speck. Is expressed in several structures, including adrenal gland; central nervous system; genitourinary system; immune system; and lung. Orthologous to human CD2BP2 (CD2 cytoplasmic tail binding protein 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 29.7), CNS E14 (RPKM 25.4) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Cd2bp2 in Genome Data Viewer
Location:
7 F3; 7 69.38 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (126790832..126795249, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (127191660..127196077, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E9301 Neighboring gene sialophorin Neighboring gene TAR (HIV) RNA binding protein 2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_20170 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:134332123-134332276 Neighboring gene STARR-positive B cell enhancer ABC_E4977 Neighboring gene TBC1 domain family, member 10b Neighboring gene STARR-positive B cell enhancer ABC_E158 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:134353944-134354145 Neighboring gene myosin light chain, phosphorylatable, fast skeletal muscle Neighboring gene septin 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The GYF domain protein CD2BP2 is critical for embryogenesis and podocyte function. Albert GI, et al. J Mol Cell Biol, 2015 Oct. PMID 26082520
  2. The nuclear GYF protein CD2BP2/U5-52K is required for T cell homeostasis. Bertazzon M, et al. Front Immunol, 2024. PMID 39308865, Free PMC Article
  3. A SMAD1/5-YAP signalling module drives radial glia self-amplification and growth of the developing cerebral cortex. Najas S, et al. Development, 2020 Jul 13. PMID 32541003
  4. Transcription factor Foxp3 and its protein partners form a complex regulatory network. Rudra D, et al. Nat Immunol, 2012 Oct. PMID 22922362, Free PMC Article
  5. Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2004 Jun 30. PMID 15368895

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (2)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ribonucleoprotein complex binding IEA
Inferred from Electronic Annotation
more info
  
enables ribonucleoprotein complex binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in RNA splicing IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of U5 snRNP IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of U5 snRNP IEA
Inferred from Electronic Annotation
more info
  
part_of U5 snRNP ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in fibrillar center IEA
Inferred from Electronic Annotation
more info
  
located_in fibrillar center ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear speck IEA
Inferred from Electronic Annotation
more info
  
colocalizes_with nuclear speck ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
CD2 antigen cytoplasmic tail-binding protein 2
Names
CD2 antigen (cytoplasmic tail) binding protein 2
CD2 cytoplasmic domain-binding protein 2
CD2 tail-binding protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001285905.1 → NP_001272834.1  CD2 antigen cytoplasmic tail-binding protein 2

    See identical proteins and their annotated locations for NP_001272834.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1-5 encode the same protein.
    Source sequence(s)
    AC122537, AK034689, BM944739
    Consensus CDS
    CCDS21859.1
    UniProtKB/Swiss-Prot
    Q3TJX5, Q9CWK3
    UniProtKB/TrEMBL
    Q3U4A3
    Related
    ENSMUSP00000145888.2, ENSMUST00000205316.2
    Conserved Domains (1) summary
    smart00444
    Location:282 → 339
    GYF; Contains conserved Gly-Tyr-Phe residues

  2. NM_001285906.1 → NP_001272835.1  CD2 antigen cytoplasmic tail-binding protein 2

    See identical proteins and their annotated locations for NP_001272835.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-5 encode the same protein.
    Source sequence(s)
    AC122537, AK030393, AK034689
    Consensus CDS
    CCDS21859.1
    UniProtKB/Swiss-Prot
    Q3TJX5, Q9CWK3
    UniProtKB/TrEMBL
    Q3U4A3
    Related
    ENSMUSP00000146167.2, ENSMUST00000206026.2
    Conserved Domains (1) summary
    smart00444
    Location:282 → 339
    GYF; Contains conserved Gly-Tyr-Phe residues

  3. NM_001285907.1 → NP_001272836.1  CD2 antigen cytoplasmic tail-binding protein 2

    See identical proteins and their annotated locations for NP_001272836.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1-5 encode the same protein.
    Source sequence(s)
    AC122537, AK034689, AK167249
    Consensus CDS
    CCDS21859.1
    UniProtKB/Swiss-Prot
    Q3TJX5, Q9CWK3
    UniProtKB/TrEMBL
    Q3U4A3
    Related
    ENSMUSP00000044790.4, ENSMUST00000035771.5
    Conserved Domains (1) summary
    smart00444
    Location:282 → 339
    GYF; Contains conserved Gly-Tyr-Phe residues

  4. NM_001357817.1 → NP_001344746.1  CD2 antigen cytoplasmic tail-binding protein 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1-5 encode the same protein.
    Source sequence(s)
    AC122537
    Consensus CDS
    CCDS21859.1
    UniProtKB/Swiss-Prot
    Q3TJX5, Q9CWK3
    UniProtKB/TrEMBL
    Q3U4A3
    Conserved Domains (1) summary
    smart00444
    Location:282 → 339
    GYF; Contains conserved Gly-Tyr-Phe residues

  5. NM_027353.4 → NP_081629.1  CD2 antigen cytoplasmic tail-binding protein 2

    See identical proteins and their annotated locations for NP_081629.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1-5 encode the same protein.
    Source sequence(s)
    AC122537, AK034689
    Consensus CDS
    CCDS21859.1
    UniProtKB/Swiss-Prot
    Q3TJX5, Q9CWK3
    UniProtKB/TrEMBL
    Q3U4A3
    Related
    ENSMUSP00000132963.2, ENSMUST00000166791.8
    Conserved Domains (1) summary
    smart00444
    Location:282 → 339
    GYF; Contains conserved Gly-Tyr-Phe residues

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    126790832..126795249 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006508198.5 → XP_006508261.1  CD2 antigen cytoplasmic tail-binding protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006508261.1

    UniProtKB/Swiss-Prot
    Q3TJX5, Q9CWK3
    UniProtKB/TrEMBL
    Q3U4A3
    Related
    ENSMUST00000205525.2
    Conserved Domains (1) summary
    smart00444
    Location:282 → 339
    GYF; Contains conserved Gly-Tyr-Phe residues

  2. XM_030242979.2 → XP_030098839.1  CD2 antigen cytoplasmic tail-binding protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q3TJX5, Q9CWK3
    UniProtKB/TrEMBL
    Q3U4A3
    Conserved Domains (1) summary
    smart00444
    Location:282 → 339
    GYF; Contains conserved Gly-Tyr-Phe residues
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CWK3.1 GenPept UniProtKB/Swiss-Prot:Q9CWK3

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