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Rpf1 ribosome production factor 1 homolog [ Mus musculus (house mouse) ]

Gene ID: 70285, updated on 27-Nov-2024

Summary

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Official Symbol
Rpf1provided by MGI
Official Full Name
ribosome production factor 1 homologprovided by MGI
Primary source
MGI:MGI:1917535
See related
Ensembl:ENSMUSG00000028187 AllianceGenome:MGI:1917535
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Bxdc5; 2210420E24Rik; 2310066N05Rik
Summary
Predicted to enable RNA binding activity. Predicted to be involved in maturation of 5.8S rRNA and maturation of LSU-rRNA. Predicted to be part of preribosome, large subunit precursor. Predicted to be active in nucleolus. Is expressed in embryo. Orthologous to human RPF1 (ribosome production factor 1 homolog). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in CNS E11.5 (RPKM 9.0), placenta adult (RPKM 7.1) and 24 other tissues See more
Orthologs
human all
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Genomic context

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See Rpf1 in Genome Data Viewer
Location:
3 H2; 3 71.57 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (146212099..146227184, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (146506344..146521423, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene chitobiase Neighboring gene spermatogenesis associated 1 Neighboring gene STARR-positive B cell enhancer ABC_E6144 Neighboring gene STARR-positive B cell enhancer ABC_E11229 Neighboring gene G protein subunit gamma 5 Neighboring gene deoxyribonuclease II beta Neighboring gene STARR-seq mESC enhancer starr_09227 Neighboring gene urate oxidase Neighboring gene predicted gene 16325 Neighboring gene sterile alpha motif domain containing 13

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. CbGRiTS: cerebellar gene regulation in time and space. Ha T, et al. Dev Biol, 2015 Jan 1. PMID 25446528
  2. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article
  3. Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function. Zhang T, et al. Sci Rep, 2017 Apr 5. PMID 28378742, Free PMC Article
  4. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
  5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC102255

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding ISO
Inferred from Sequence Orthology
more info
  
enables RNA binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables rRNA primary transcript binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in maturation of 5.8S rRNA IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in maturation of LSU-rRNA IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in rRNA processing IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of preribosome, large subunit precursor IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ribosome production factor 1
Names
RNA processing factor 1
brix domain containing 5
brix domain-containing protein 5
ribosome biogenesis protein RPF1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_027332.3 → NP_081608.1  ribosome production factor 1 isoform 1

    See identical proteins and their annotated locations for NP_081608.1

    Status: VALIDATED

    Source sequence(s)
    AC141632, AK008988, AK162073, BC089369
    Consensus CDS
    CCDS80049.1
    UniProtKB/TrEMBL
    A0A0G2JFR7
    Related
    ENSMUSP00000143279.2, ENSMUST00000199079.2
    Conserved Domains (1) summary
    cl00935
    Location:142 → 208
    Brix; Brix domain

  2. NM_027371.3 → NP_081647.2  ribosome production factor 1 isoform 2

    See identical proteins and their annotated locations for NP_081647.2

    Status: VALIDATED

    Source sequence(s)
    AK162073, BC089369
    Consensus CDS
    CCDS51089.1
    UniProtKB/Swiss-Prot
    Q3TBS4, Q5EBN9, Q7TND5, Q8K343
    Related
    ENSMUSP00000029838.7, ENSMUST00000029838.11
    Conserved Domains (1) summary
    smart00879
    Location:145 → 314
    Brix; The Brix domain is found in a number of eukaryotic proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    146212099..146227184 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036163302.1 → XP_036019195.1  ribosome production factor 1 isoform X1

    Conserved Domains (1) summary
    smart00879
    Location:145 → 314
    Brix; The Brix domain is found in a number of eukaryotic proteins

  2. XM_036163303.1 → XP_036019196.1  ribosome production factor 1 isoform X2

    Conserved Domains (1) summary
    cl00935
    Location:142 → 205
    Brix; Brix domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7TND5.2 GenPept UniProtKB/Swiss-Prot:Q7TND5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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