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Polr3f polymerase (RNA) III (DNA directed) polypeptide F [ Mus musculus (house mouse) ]

Gene ID: 70408, updated on 27-Nov-2024

Summary

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Official Symbol
Polr3fprovided by MGI
Official Full Name
polymerase (RNA) III (DNA directed) polypeptide Fprovided by MGI
Primary source
MGI:MGI:1924086
See related
Ensembl:ENSMUSG00000027427 AllianceGenome:MGI:1924086
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
RPC6; RPC39; 2810411G20Rik; 3010019O03Rik; 3110032A07Rik
Summary
Predicted to enable 4 iron, 4 sulfur cluster binding activity and double-stranded DNA binding activity. Predicted to be involved in positive regulation of innate immune response and positive regulation of interferon-beta production. Predicted to be part of RNA polymerase III complex. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and respiratory system. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human POLR3F (RNA polymerase III subunit F). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 5.5), CNS E14 (RPKM 4.5) and 25 other tissues See more
Orthologs
human all
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Genomic context

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See Polr3f in Genome Data Viewer
Location:
2 G1; 2 71.02 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (144369665..144383699)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (144527745..144541779)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene zinc finger protein 133, pseudogene Neighboring gene STARR-seq mESC enhancer starr_05917 Neighboring gene double zinc ribbon and ankyrin repeat domains 1 Neighboring gene STARR-seq mESC enhancer starr_05918 Neighboring gene retinoblastoma binding protein 9, serine hydrolase Neighboring gene STARR-positive B cell enhancer ABC_E1603 Neighboring gene predicted gene, 34292 Neighboring gene SEC23 homolog B, COPII coat complex component

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Isolation and characterization of monoclonal antibodies directed against subunits of human RNA polymerases I, II, and III. Jones E, et al. Exp Cell Res, 2000 Jan 10. PMID 10623476
  2. Genetic analysis of albuminuria in a cross between C57BL/6J and DBA/2J mice. Sheehan S, et al. Am J Physiol Renal Physiol, 2007 Nov. PMID 17804484
  3. Three human RNA polymerase III-specific subunits form a subcomplex with a selective function in specific transcription initiation. Wang Z, et al. Genes Dev, 1997 May 15. PMID 9171375
  4. Identification of positional candidate genes for body weight and adiposity in subcongenic mice. Chiu S, et al. Physiol Genomics, 2007 Sep 19. PMID 17536020
  5. An atlas of combinatorial transcriptional regulation in mouse and man. Ravasi T, et al. Cell, 2010 Mar 5. PMID 20211142, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC11656

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 4 iron, 4 sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
  
enables 4 iron, 4 sulfur cluster binding ISO
Inferred from Sequence Orthology
more info
  
enables double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables double-stranded DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in defense response to virus IEA
Inferred from Electronic Annotation
more info
  
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of innate immune response ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of innate immune response ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of interferon-beta production ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of interferon-beta production ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in transcription by RNA polymerase III IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of RNA polymerase III complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of RNA polymerase III complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
DNA-directed RNA polymerase III subunit RPC6
Names
DNA-directed RNA polymerase III subunit F
RNA polymerase III subunit C6
NP_084039.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_029763.3 → NP_084039.2  DNA-directed RNA polymerase III subunit RPC6

    See identical proteins and their annotated locations for NP_084039.2

    Status: VALIDATED

    Source sequence(s)
    AK029286, AK036166
    Consensus CDS
    CCDS16820.1
    UniProtKB/Swiss-Prot
    Q544K6, Q921X6
    UniProtKB/TrEMBL
    Q8C108
    Related
    ENSMUSP00000028914.3, ENSMUST00000028914.9
    Conserved Domains (1) summary
    pfam05158
    Location:12 → 315
    RNA_pol_Rpc34; RNA polymerase Rpc34 subunit

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    144369665..144383699
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_027417.1: Suppressed sequence

    Description
    NM_027417.1: This RefSeq record was removed by NCBI staff. Contact [email protected] for further information.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q921X6.1 GenPept UniProtKB/Swiss-Prot:Q921X6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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