Mpc2 mitochondrial pyruvate carrier 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mpc2provided by MGI
Official Full Name: mitochondrial pyruvate carrier 2provided by MGI
Primary source: MGI:MGI:1917706
See related: Ensembl:ENSMUSG00000026568 AllianceGenome:MGI:1917706
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Brp44; ESTM43; 0610006C01Rik; 2010002I07Rik; 2610205H19Rik
Summary: Enables pyruvate transmembrane transporter activity. Involved in acetyl-CoA biosynthetic process from pyruvate. Acts upstream of or within mitochondrial pyruvate transmembrane transport and positive regulation of insulin secretion involved in cellular response to glucose stimulus. Located in mitochondrion. Is active in mitochondrial inner membrane. Is expressed in several structures, including brain; early conceptus; heart; and liver. Orthologous to human MPC2 (mitochondrial pyruvate carrier 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in adrenal adult (RPKM 132.5), testis adult (RPKM 127.7) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 H2.3; 1 72.8 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (165288829..165308787)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (165461260..165481218)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Nutritional modulation of heart failure in mitochondrial pyruvate carrier-deficient mice.
Title: Nutritional modulation of heart failure in mitochondrial pyruvate carrier-deficient mice.
Inhibition of pyruvate metabolism by tolylfluanid required MPC2.
Title: Inhibition of the Mitochondrial Pyruvate Carrier by Tolylfluanid.
The interaction between TZDs and MPC2 is not affected by loss of the N-terminal 16 amino acid.
Title: The beneficial metabolic effects of insulin sensitizers are not attenuated by mitochondrial pyruvate carrier 2 hypomorphism.
MPC2 acetylation is increased in Diabetic Heart mitochondria. This study supports the conclusion that deficient pyruvate transport activity, mediated in part by acetylation of MPC2, is a contributor to metabolic inflexibility in the diabetic heart.
Title: Decreased Mitochondrial Pyruvate Transport Activity in the Diabetic Heart: ROLE OF MITOCHONDRIAL PYRUVATE CARRIER 2 (MPC2) ACETYLATION.
Oxidative glutaminolysis supports the TCA cycle in mouse cells lacking MPC1/2.
Title: Regulation of substrate utilization by the mitochondrial pyruvate carrier.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (8) 1 citation
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AA536926 (e-PCR)
- UniSTS:160011

AA108335 (e-PCR), detects polymorphism
- UniSTS:143029

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables pyruvate transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
contributes_to pyruvate transmembrane transporter activity	IGI Inferred from Genetic Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within acetyl-CoA biosynthetic process from pyruvate	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in acetyl-CoA biosynthetic process from pyruvate	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitochondrial pyruvate transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within mitochondrial pyruvate transmembrane transport	IGI Inferred from Genetic Interaction more info	PubMed
involved_in mitochondrial pyruvate transmembrane transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of insulin secretion involved in cellular response to glucose stimulus	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in mitochondrial inner membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in mitochondrial inner membrane	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial inner membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: mitochondrial pyruvate carrier 2

Names: brain protein 44

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.