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Zdhhc1 zinc finger, DHHC domain containing 1 [ Mus musculus (house mouse) ]

Gene ID: 70796, updated on 4-Jan-2025

Summary

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Official Symbol
Zdhhc1provided by MGI
Official Full Name
zinc finger, DHHC domain containing 1provided by MGI
Primary source
MGI:MGI:1918046
See related
Ensembl:ENSMUSG00000039199 AllianceGenome:MGI:1918046
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
DHHC-1; 4432412D04Rik
Summary
Enables protein-cysteine S-palmitoyltransferase activity. Involved in several processes, including antiviral innate immune response; peptidyl-L-cysteine S-palmitoylation; and positive regulation of protein-containing complex assembly. Acts upstream of or within protein palmitoylation. Located in endosome membrane. Is expressed in several structures, including adrenal gland; central nervous system; genitourinary system; heart; and lung. Orthologous to human ZDHHC1 (zinc finger DHHC-type containing 1). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Ubiquitous expression in lung adult (RPKM 28.6), ovary adult (RPKM 27.7) and 24 other tissues See more
Orthologs
human all
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Genomic context

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See Zdhhc1 in Genome Data Viewer
Location:
8 D3; 8 53.04 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (106199055..106223694, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (105472419..105497062, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene leucine rich repeat containing 36 Neighboring gene tubulin polymerization-promoting protein family member 3 Neighboring gene ferritin light chain 1 pseudogene Neighboring gene hydroxysteroid 11-beta dehydrogenase 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The DHHC domain: a new highly conserved cysteine-rich motif. Putilina T, et al. Mol Cell Biochem, 1999 May. PMID 10395086
  2. The ER-associated protein ZDHHC1 is a positive regulator of DNA virus-triggered, MITA/STING-dependent innate immune signaling. Zhou Q, et al. Cell Host Microbe, 2014 Oct 8. PMID 25299331
  3. Consecutive palmitoylation and phosphorylation orchestrates NLRP3 membrane trafficking and inflammasome activation. Nie L, et al. Mol Cell, 2024 Sep 5. PMID 39173637
  4. In silico screening for palmitoyl substrates reveals a role for DHHC1/3/10 (zDHHC1/3/11)-mediated neurochondrin palmitoylation in its targeting to Rab5-positive endosomes. Oku S, et al. J Biol Chem, 2013 Jul 5. PMID 23687301, Free PMC Article
  5. Identification of PSD-95 palmitoylating enzymes. Fukata M, et al. Neuron, 2004 Dec 16. PMID 15603741

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. In silico screening for palmitoyl substrates reveals a role for DHHC1/3/10 (zDHHC1/3/11)-mediated neurochondrin palmitoylation in its targeting to Rab5-positive endosomes.
    Title: In silico screening for palmitoyl substrates reveals a role for DHHC1/3/10 (zDHHC1/3/11)-mediated neurochondrin palmitoylation in its targeting to Rab5-positive endosomes.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Gene trapped (1) 
  • Targeted (1)  1 citation

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables palmitoyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables palmitoyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein-cysteine S-palmitoyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein-cysteine S-palmitoyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in antiviral innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in antiviral innate immune response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in antiviral innate immune response ISO
Inferred from Sequence Orthology
more info
  
involved_in peptidyl-L-cysteine S-palmitoylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of NLRP3 inflammasome complex assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of defense response to virus by host IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of defense response to virus by host ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein localization to endosome IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of protein oligomerization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within protein palmitoylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein palmitoylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein targeting to membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
located_in endosome membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
palmitoyltransferase ZDHHC1
Names
probable palmitoyltransferase ZDHHC1
zinc finger DHHC domain-containing protein 1
NP_001344181.1
NP_001365935.1
NP_001365936.1
NP_001365937.1
NP_001365938.1
NP_001365939.1
NP_001365940.1
NP_780369.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357252.2 → NP_001344181.1  palmitoyltransferase ZDHHC1 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2), as well as variant 5, encodes isoform 2.
    Source sequence(s)
    AC090480, AC151573
    UniProtKB/TrEMBL
    B7ZMY5
    Conserved Domains (1) summary
    pfam01529
    Location:126 → 281
    DHHC; DHHC palmitoyltransferase

  2. NM_001379006.1 → NP_001365935.1  palmitoyltransferase ZDHHC1 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3), as well as variants 1 and 4, encodes isoform 1.
    Source sequence(s)
    AC090480, AC151573
    UniProtKB/Swiss-Prot
    Q0VE36, Q8BJ24, Q8R0N9
    Conserved Domains (1) summary
    pfam01529
    Location:126 → 281
    DHHC; DHHC palmitoyltransferase

  3. NM_001379007.1 → NP_001365936.1  palmitoyltransferase ZDHHC1 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4), as well as variants 1 and 3, encodes isoform 1.
    Source sequence(s)
    AC090480, AC151573
    UniProtKB/Swiss-Prot
    Q0VE36, Q8BJ24, Q8R0N9
    Conserved Domains (1) summary
    pfam01529
    Location:126 → 281
    DHHC; DHHC palmitoyltransferase

  4. NM_001379008.1 → NP_001365937.1  palmitoyltransferase ZDHHC1 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5), as well as variant 2, encodes isoform 2.
    Source sequence(s)
    AC090480, AC151573
    UniProtKB/TrEMBL
    B7ZMY5
    Conserved Domains (1) summary
    pfam01529
    Location:126 → 281
    DHHC; DHHC palmitoyltransferase

  5. NM_001379009.1 → NP_001365938.1  palmitoyltransferase ZDHHC1 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6), as well as variants 7 and 8, encodes isoform 3.
    Source sequence(s)
    AC090480, AC151573
    Conserved Domains (1) summary
    pfam01529
    Location:126 → 281
    DHHC; DHHC palmitoyltransferase

  6. NM_001379010.1 → NP_001365939.1  palmitoyltransferase ZDHHC1 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7), as well as variants 6 and 8, encodes isoform 3.
    Source sequence(s)
    AC090480, AC151573
    Conserved Domains (1) summary
    pfam01529
    Location:126 → 281
    DHHC; DHHC palmitoyltransferase

  7. NM_001379011.1 → NP_001365940.1  palmitoyltransferase ZDHHC1 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8), as well as variants 6 and 7, encodes isoform 3.
    Source sequence(s)
    AC090480, AC151573
    Conserved Domains (1) summary
    pfam01529
    Location:126 → 281
    DHHC; DHHC palmitoyltransferase

  8. NM_175160.5 → NP_780369.1  palmitoyltransferase ZDHHC1 isoform 1

    See identical proteins and their annotated locations for NP_780369.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Variants 1, 3, and 4 all encode the same isoform (1).
    Source sequence(s)
    AC090480, AC151573
    Consensus CDS
    CCDS22603.1
    UniProtKB/Swiss-Prot
    Q0VE36, Q8BJ24, Q8R0N9
    Related
    ENSMUSP00000148381.2, ENSMUST00000212303.2
    Conserved Domains (1) summary
    pfam01529
    Location:126 → 281
    DHHC; DHHC palmitoyltransferase

RNA

  1. NR_166407.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC090480, AC151573

  2. NR_166408.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC090480, AC151573

  3. NR_166409.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC090480, AC151573

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    106199055..106223694 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8R0N9.2 GenPept UniProtKB/Swiss-Prot:Q8R0N9

Gene LinkOut

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