TLE3 TLE family member 3, transcriptional corepressor [Homo sapiens (human)] - Gene

Summary

Official Symbol: TLE3provided by HGNC
Official Full Name: TLE family member 3, transcriptional corepressorprovided by HGNC
Primary source: HGNC:HGNC:11839
See related: Ensembl:ENSG00000140332 MIM:600190; AllianceGenome:HGNC:11839
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: ESG; ESG3; GRG3; HsT18976
Summary: This gene encodes a transcriptional co-repressor protein that belongs to the transducin-like enhancer family of proteins. The members of this family function in the Notch signaling pathway that regulates determination of cell fate during development. Expression of this gene has been associated with a favorable outcome to chemotherapy with taxanes for ovarian carcinoma. Alternate splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Sep 2013]
Expression: Ubiquitous expression in bone marrow (RPKM 20.9), prostate (RPKM 8.6) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 15q23

Exon count:: 23

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	15	NC_000015.10 (70047790..70097917, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	15	NC_060939.1 (67870017..67920141, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	15	NC_000015.9 (70340129..70390256, complement)

Chromosome 15 - NC_000015.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The Wnt-pathway corepressor TLE3 interacts with the histone methyltransferase KMT1A to inhibit differentiation in Rhabdomyosarcoma.
Title: The Wnt-pathway corepressor TLE3 interacts with the histone methyltransferase KMT1A to inhibit differentiation in Rhabdomyosarcoma.
HHEX suppresses advanced thyroid cancer by interacting with TLE3.
Title: HHEX suppresses advanced thyroid cancer by interacting with TLE3.
Enhancer recruitment of transcription repressors RUNX1 and TLE3 by mis-expressed FOXC1 blocks differentiation in acute myeloid leukemia.
Title: Enhancer recruitment of transcription repressors RUNX1 and TLE3 by mis-expressed FOXC1 blocks differentiation in acute myeloid leukemia.
Differential functions of TLE1 and TLE3 depending on a specific phosphorylation site.
Title: Differential functions of TLE1 and TLE3 depending on a specific phosphorylation site.
vour findings reveal a mechanistic link between TLE3 and GR-mediated resistance to AR inhibitors in human prostate cancer
Title: TLE3 loss confers AR inhibitor resistance by facilitating GR-mediated human prostate cancer cell growth.
RNF6-mediated ubiquitination and degradation of TLE3 activates the Wnt/beta-catenin pathway in colorectal carcinogenesis
Title: RNF6 Promotes Colorectal Cancer by Activating the Wnt/β-Catenin Pathway via Ubiquitination of TLE3.
Patients with TLE3-negative tumors displayed poorer outcomes regarding progression-free survival than patients with TLE3-positive tumors when prognosis within the group of patients with triple-negative breast cancer (TNBC) lesions was analyzed. In contrast, no such difference in prognosis was found in a comparison of TLE-3 positive/negative patients in the group of all patients.
Title: Identification of predictive markers of the therapeutic effect of eribulin chemotherapy for locally advanced or metastatic breast cancer.
Wnt signaling pathway inactivates the TLE3 co-repressor via HECT E3 ubiquitin ligase Hyd/UBR5 ubiquitination.
Title: Wnt-Dependent Inactivation of the Groucho/TLE Co-repressor by the HECT E3 Ubiquitin Ligase Hyd/UBR5.
Data indicate that microRNA miR-744 activated Wnt/beta-catenin pathway by targeting multiple negative regulators of Wnt/beta-catenin signaling, including SFRP1, GSK3beta, TLE3 and NKD1, and that NKD1 is a major functional target of miR-744.
Title: MicroRNA-744 promotes prostate cancer progression through aberrantly activating Wnt/β-catenin signaling.
Increased adipose tissue (AT) TLE3 in subjects with type 2 diabetes and in AT from high fat diet and PPARgamma knockout mice suggest that TLE3 may play an adaptive regulatory role that improves AT function under decreased PPARgamma expression
Title: Transducin-like enhancer of split 3 (TLE3) in adipose tissue is increased in situations characterized by decreased PPARγ gene expression.

Submit: New GeneRIF Correction See all GeneRIFs (15)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Biological insights from 108 schizophrenia-associated genetic loci. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study of lung function phenotypes in a founder population. EBI GWAS Catalog EBI GWAS CatalogPubMed
Heritability and genetic association analysis of cognition in the&#x000a0;Diabetes Heart Study. EBI GWAS Catalog EBI GWAS CatalogPubMed
Hundreds of variants clustered in genomic loci and biological pathways affect human height. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH66842 (e-PCR)
- UniSTS:44323

RH93831 (e-PCR)
- UniSTS:88487

WI-10764 (e-PCR)
- UniSTS:37108

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription corepressor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in animal organ morphogenesis	TAS Traceable Author Statement more info	PubMed
involved_in negative regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of cold-induced thermogenesis	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in signal transduction	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
part_of beta-catenin-TCF complex	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in nucleoplasm	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IDA Inferred from Direct Assay more info	PubMed
part_of transcription regulator complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: transducin-like enhancer protein 3

Names: enhancer of split groucho 3; enhancer of split groucho-like protein 3; transducin like enhancer of split 3; transducin-like enhancer of split 3 (E(sp1) homolog, Drosophila); transducin-like enhancer of split 3, homolog of Drosophila E(sp1)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001105192.3 → NP_001098662.1 transducin-like enhancer protein 3 isoform b

See identical proteins and their annotated locations for NP_001098662.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice site in the coding region compared to variant 1. The encoded isoform (b) is shorter than isoform a.

Source sequence(s)

AB046767, AC026583, AC068327, AK315058, BC043247, BM676381

Consensus CDS

CCDS45294.1

UniProtKB/TrEMBL

Q6PRX3

Related

ENSP00000394717.3, ENST00000451782.7

Conserved Domains (3) summary

cd00200
Location:481 → 766

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:486 → 525

7WD40; WD40 repeat [structural motif]

pfam03920
Location:9 → 133

TLE_N; Groucho/TLE N-terminal Q-rich domain
NM_001282979.2 → NP_001269908.1 transducin-like enhancer protein 3 isoform e

See identical proteins and their annotated locations for NP_001269908.1

Status: REVIEWED

Description

Transcript Variant: This variant (5) uses two alternate in-frame splice sites in the 3' coding region compared to variant 1. The encoded isoform (e) is shorter than isoform a.

Source sequence(s)

AB046767, AC026583, AC068327, AY583459, BC043247, BM676381, M99438

Consensus CDS

CCDS61692.1

UniProtKB/TrEMBL

Q6PRX3

Related

ENSP00000453083.1, ENST00000557997.5

Conserved Domains (3) summary

cd00200
Location:476 → 761

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:481 → 520

7WD40; WD40 repeat [structural motif]

pfam03920
Location:9 → 133

TLE_N; Groucho/TLE N-terminal Q-rich domain
NM_001282980.2 → NP_001269909.1 transducin-like enhancer protein 3 isoform d

See identical proteins and their annotated locations for NP_001269909.1

Status: REVIEWED

Description

Transcript Variant: This variant (4) uses an alternate in-frame splice site in the 3' coding region compared to variant 1. The encoded isoform (d) is shorter than isoform a.

Source sequence(s)

AB046767, AC026583, AC068327, BC043247, BM676381

Consensus CDS

CCDS61691.1

UniProtKB/TrEMBL

Q6PRX2

Related

ENSP00000453435.1, ENST00000558379.5

Conserved Domains (3) summary

cd00200
Location:479 → 764

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:484 → 523

7WD40; WD40 repeat [structural motif]

pfam03920
Location:9 → 133

TLE_N; Groucho/TLE N-terminal Q-rich domain
NM_001282981.2 → NP_001269910.1 transducin-like enhancer protein 3 isoform f

See identical proteins and their annotated locations for NP_001269910.1

Status: REVIEWED

Description

Transcript Variant: This variant (6) has multiple differences compared to variant 1. These differences result in a novel 5' coding region and 5' UTR compared to variant 1. The encoded isoform (f) is shorter than isoform a.

Source sequence(s)

AB046767, AC068327, AK298482, BM676381, BP373048

Consensus CDS

CCDS61689.1

UniProtKB/TrEMBL

H0YKT5

Related

ENSP00000415057.3, ENST00000440567.7

Conserved Domains (3) summary

cd00200
Location:474 → 759

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:479 → 518

7WD40; WD40 repeat [structural motif]

pfam03920
Location:2 → 126

TLE_N; Groucho/TLE N-terminal Q-rich domain
NM_001282982.2 → NP_001269911.1 transducin-like enhancer protein 3 isoform g

See identical proteins and their annotated locations for NP_001269911.1

Status: REVIEWED

Description

Transcript Variant: This variant (7) represents the use of an alternate promoter and has multiple differences compared to variant 1. These differences result in a distinct 5' UTR and cause translation initiation at a downstream start codon compared to variant 1. The encoded isoform (g) is shorter than isoform a.

Source sequence(s)

AB046767, AC026583, AC068327, AK096779, BM676381

UniProtKB/TrEMBL

B3KUA2

Conserved Domains (3) summary

cd00200
Location:411 → 696

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:416 → 455

7WD40; WD40 repeat [structural motif]

pfam03920
Location:1 → 77

TLE_N; Groucho/TLE N-terminal Q-rich domain
NM_005078.4 → NP_005069.2 transducin-like enhancer protein 3 isoform a

See identical proteins and their annotated locations for NP_005069.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).

Source sequence(s)

AB046767, AC026583, AC068327, BC043247, BM676381, M99438

Consensus CDS

CCDS45293.1

UniProtKB/Swiss-Prot

B4DPT0, E9PD64, F8W964, Q04726, Q6PI57, Q8IVV6, Q8WVR2, Q9HCM5

UniProtKB/TrEMBL

Q6PRX2

Related

ENSP00000452871.1, ENST00000558939.5

Conserved Domains (3) summary

cd00200
Location:484 → 769

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:489 → 528

7WD40; WD40 repeat [structural motif]

pfam03920
Location:9 → 133

TLE_N; Groucho/TLE N-terminal Q-rich domain
NM_020908.3 → NP_065959.1 transducin-like enhancer protein 3 isoform c

See identical proteins and their annotated locations for NP_065959.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 3' coding region compared to variant 1. The encoded isoform (c) is shorter than isoform a.

Source sequence(s)

AB046767, AC026583, AC068327, BC043247, BM676381

Consensus CDS

CCDS58375.1

UniProtKB/TrEMBL

Q6PRX2

Related

ENSP00000319233.8, ENST00000317509.12

Conserved Domains (4) summary

cd00200
Location:472 → 757

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

pfam05109
Location:251 → 460

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

sd00039
Location:477 → 516

7WD40; WD40 repeat [structural motif]

pfam03920
Location:9 → 133

TLE_N; Groucho/TLE N-terminal Q-rich domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000015.10 Reference GRCh38.p14 Primary Assembly

Range

70047790..70097917 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047432993.1 → XP_047288949.1 transducin-like enhancer protein 3 isoform X14
XM_047432992.1 → XP_047288948.1 transducin-like enhancer protein 3 isoform X12
XM_011521983.4 → XP_011520285.1 transducin-like enhancer protein 3 isoform X13

UniProtKB/TrEMBL

Q6PRX2

Conserved Domains (4) summary

COG2319
Location:406 → 691

WD40; WD40 repeat [General function prediction only]

cd00200
Location:405 → 690

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

pfam03920
Location:1 → 124

TLE_N; Groucho/TLE N-terminal Q-rich domain

sd00039
Location:410 → 449

7WD40; WD40 repeat [structural motif]
XM_011521982.4 → XP_011520284.1 transducin-like enhancer protein 3 isoform X11

UniProtKB/TrEMBL

Q6PRX2

Conserved Domains (4) summary

COG2319
Location:411 → 696

WD40; WD40 repeat [General function prediction only]

cd00200
Location:410 → 695

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

pfam03920
Location:1 → 124

TLE_N; Groucho/TLE N-terminal Q-rich domain

sd00039
Location:415 → 454

7WD40; WD40 repeat [structural motif]
XM_006720665.5 → XP_006720728.1 transducin-like enhancer protein 3 isoform X16

UniProtKB/TrEMBL

Q6PRX3

Conserved Domains (3) summary

cd00200
Location:475 → 760

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:480 → 519

7WD40; WD40 repeat [structural motif]

pfam03920
Location:9 → 132

TLE_N; Groucho/TLE N-terminal Q-rich domain
XM_011521980.4 → XP_011520282.1 transducin-like enhancer protein 3 isoform X7

UniProtKB/TrEMBL

Q6PRX2

Conserved Domains (3) summary

cd00200
Location:483 → 768

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:488 → 527

7WD40; WD40 repeat [structural motif]

pfam03920
Location:9 → 132

TLE_N; Groucho/TLE N-terminal Q-rich domain
XM_005254633.4 → XP_005254690.1 transducin-like enhancer protein 3 isoform X17

See identical proteins and their annotated locations for XP_005254690.1

UniProtKB/TrEMBL

Q6PRX2

Conserved Domains (3) summary

cd00200
Location:467 → 752

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:472 → 511

7WD40; WD40 repeat [structural motif]

pfam03920
Location:9 → 133

TLE_N; Groucho/TLE N-terminal Q-rich domain
XM_011521977.4 → XP_011520279.1 transducin-like enhancer protein 3 isoform X2

UniProtKB/TrEMBL

Q6PRX2

Conserved Domains (3) summary

cd00200
Location:493 → 778

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:498 → 537

7WD40; WD40 repeat [structural motif]

pfam03920
Location:9 → 142

TLE_N; Groucho/TLE N-terminal Q-rich domain
XM_005254628.5 → XP_005254685.1 transducin-like enhancer protein 3 isoform X10

UniProtKB/TrEMBL

Q6PRX2

Conserved Domains (3) summary

cd00200
Location:477 → 762

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:482 → 521

7WD40; WD40 repeat [structural motif]

pfam03920
Location:9 → 143

TLE_N; Groucho/TLE N-terminal Q-rich domain
XM_005254625.5 → XP_005254682.1 transducin-like enhancer protein 3 isoform X8

UniProtKB/TrEMBL

Q6PRX2

Conserved Domains (4) summary

cd00200
Location:482 → 767

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

pfam05109
Location:261 → 470

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

sd00039
Location:487 → 526

7WD40; WD40 repeat [structural motif]

pfam03920
Location:9 → 143

TLE_N; Groucho/TLE N-terminal Q-rich domain
XM_005254623.5 → XP_005254680.1 transducin-like enhancer protein 3 isoform X5

UniProtKB/TrEMBL

Q6PRX3

Conserved Domains (3) summary

cd00200
Location:486 → 771

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:491 → 530

7WD40; WD40 repeat [structural motif]

pfam03920
Location:9 → 143

TLE_N; Groucho/TLE N-terminal Q-rich domain
XM_005254622.6 → XP_005254679.1 transducin-like enhancer protein 3 isoform X3

UniProtKB/TrEMBL

Q6PRX3

Conserved Domains (3) summary

cd00200
Location:491 → 776

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:496 → 535

7WD40; WD40 repeat [structural motif]

pfam03920
Location:9 → 143

TLE_N; Groucho/TLE N-terminal Q-rich domain
XM_011521978.4 → XP_011520280.1 transducin-like enhancer protein 3 isoform X4

UniProtKB/TrEMBL

Q6PRX2

Conserved Domains (3) summary

cd00200
Location:489 → 774

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:494 → 533

7WD40; WD40 repeat [structural motif]

pfam03920
Location:9 → 143

TLE_N; Groucho/TLE N-terminal Q-rich domain
XM_011521976.4 → XP_011520278.1 transducin-like enhancer protein 3 isoform X1

See identical proteins and their annotated locations for XP_011520278.1

UniProtKB/TrEMBL

H0YL70, Q6PRX2

Related

ENSP00000453081.1, ENST00000559929.5

Conserved Domains (3) summary

cd00200
Location:494 → 779

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:499 → 538

7WD40; WD40 repeat [structural motif]

pfam03920
Location:9 → 143

TLE_N; Groucho/TLE N-terminal Q-rich domain
XM_011521979.4 → XP_011520281.1 transducin-like enhancer protein 3 isoform X6

See identical proteins and their annotated locations for XP_011520281.1

UniProtKB/TrEMBL

H0YNT2

Related

ENSP00000453760.1, ENST00000559048.5

Conserved Domains (3) summary

cd00200
Location:422 → 707

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:427 → 466

7WD40; WD40 repeat [structural motif]

pfam03920
Location:1 → 76

TLE_N; Groucho/TLE N-terminal Q-rich domain
XM_011521981.3 → XP_011520283.1 transducin-like enhancer protein 3 isoform X9

UniProtKB/TrEMBL

Q6PRX2

Conserved Domains (4) summary

COG2319
Location:488 → 747

WD40; WD40 repeat [General function prediction only]

cd00200
Location:494 → 738

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

pfam03920
Location:1 → 143

TLE_N; Groucho/TLE N-terminal Q-rich domain

sd00039
Location:499 → 538

7WD40; WD40 repeat [structural motif]
XM_017022532.3 → XP_016878021.1 transducin-like enhancer protein 3 isoform X15

UniProtKB/TrEMBL

H0YLI3

Related

ENSP00000453373.1, ENST00000561453.5

Alternate T2T-CHM13v2.0

Genomic

NC_060939.1 Alternate T2T-CHM13v2.0

Range

67870017..67920141 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054378731.1 → XP_054234706.1 transducin-like enhancer protein 3 isoform X14
XM_054378729.1 → XP_054234704.1 transducin-like enhancer protein 3 isoform X12
XM_054378730.1 → XP_054234705.1 transducin-like enhancer protein 3 isoform X13
XM_054378728.1 → XP_054234703.1 transducin-like enhancer protein 3 isoform X11
XM_054378733.1 → XP_054234708.1 transducin-like enhancer protein 3 isoform X16
XM_054378724.1 → XP_054234699.1 transducin-like enhancer protein 3 isoform X7
XM_054378734.1 → XP_054234709.1 transducin-like enhancer protein 3 isoform X17
XM_054378719.1 → XP_054234694.1 transducin-like enhancer protein 3 isoform X2
XM_054378727.1 → XP_054234702.1 transducin-like enhancer protein 3 isoform X10
XM_054378725.1 → XP_054234700.1 transducin-like enhancer protein 3 isoform X8
XM_054378722.1 → XP_054234697.1 transducin-like enhancer protein 3 isoform X5
XM_054378720.1 → XP_054234695.1 transducin-like enhancer protein 3 isoform X3
XM_054378721.1 → XP_054234696.1 transducin-like enhancer protein 3 isoform X4
XM_054378718.1 → XP_054234693.1 transducin-like enhancer protein 3 isoform X1

UniProtKB/TrEMBL

H0YL70
XM_054378723.1 → XP_054234698.1 transducin-like enhancer protein 3 isoform X6
XM_054378726.1 → XP_054234701.1 transducin-like enhancer protein 3 isoform X9
XM_054378732.1 → XP_054234707.1 transducin-like enhancer protein 3 isoform X15