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Adam30 a disintegrin and metallopeptidase domain 30 [ Mus musculus (house mouse) ]

Gene ID: 71078, updated on 9-Dec-2024

Summary

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Official Symbol
Adam30provided by MGI
Official Full Name
a disintegrin and metallopeptidase domain 30provided by MGI
Primary source
MGI:MGI:1918328
See related
Ensembl:ENSMUSG00000043468 AllianceGenome:MGI:1918328
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
svph4; 4933424D07Rik
Summary
Predicted to enable metalloendopeptidase activity. Predicted to be involved in male gonad development and proteolysis. Located in external side of plasma membrane and sperm head plasma membrane. Orthologous to human ADAM30 (ADAM metallopeptidase domain 30). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
human all
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Genomic context

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See Adam30 in Genome Data Viewer
Location:
3 F2.2; 3 42.63 cM
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (98067950..98071485)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (98160634..98164169)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E3452 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:97737302-97737411 Neighboring gene VISTA enhancer mm576 Neighboring gene predicted gene 5544 Neighboring gene STARR-positive B cell enhancer ABC_E6087 Neighboring gene STARR-positive B cell enhancer ABC_E3453 Neighboring gene notch 2 Neighboring gene predicted gene, 40103 Neighboring gene STARR-seq mESC enhancer starr_08478 Neighboring gene STARR-positive B cell enhancer mm9_chr3:97961638-97961939 Neighboring gene RNA binding motif protein, X chromosome pseudogene Neighboring gene predicted gene, 40104

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Characterization and comparative genomic analysis of intronless Adams with testicular gene expression. Choi I, et al. Genomics, 2004 Apr. PMID 15028286
  2. Comprehensive analysis of reproductive ADAMs: relationship of ADAM4 and ADAM6 with an ADAM complex required for fertilization in mice. Han C, et al. Biol Reprod, 2009 May. PMID 19129510
  3. Positive selection in the adhesion domain of Mus sperm Adam genes through gene duplications and function-driven gene complex formations. Grayson P, et al. BMC Evol Biol, 2013 Sep 30. PMID 24079728, Free PMC Article
  4. A mouse knockout library for secreted and transmembrane proteins. Tang T, et al. Nat Biotechnol, 2010 Jul. PMID 20562862
  5. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (1)  1 citation

General gene information

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Homology

Clone Names

  • MGC132801, MGC132802, 4933424D07Rik

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metalloendopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in male gonad development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in external side of plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in sperm head plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in sperm head plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
disintegrin and metalloproteinase domain-containing protein 30
Names
a disintegrin and metalloproteinase domain 30

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_027665.2 → NP_081941.1  disintegrin and metalloproteinase domain-containing protein 30 precursor

    See identical proteins and their annotated locations for NP_081941.1

    Status: VALIDATED

    Source sequence(s)
    AK077058, BB615407
    Consensus CDS
    CCDS17660.1
    UniProtKB/TrEMBL
    Q811Q3
    Related
    ENSMUSP00000060505.4, ENSMUST00000050342.5
    Conserved Domains (5) summary
    smart00608
    Location:483 → 624
    ACR; ADAM Cysteine-Rich Domain
    cd04269
    Location:202 → 391
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
    pfam00200
    Location:407 → 479
    Disintegrin; Disintegrin
    pfam01421
    Location:202 → 393
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:58 → 158
    Pep_M12B_propep; Reprolysin family propeptide

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    98067950..98071485
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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