Oxsm 3-oxoacyl-ACP synthase, mitochondrial [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Oxsmprovided by MGI
Official Full Name: 3-oxoacyl-ACP synthase, mitochondrialprovided by MGI
Primary source: MGI:MGI:1918397
See related: Ensembl:ENSMUSG00000021786 AllianceGenome:MGI:1918397
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 4933425A18Rik
Summary: Predicted to enable 3-oxoacyl-[acyl-carrier-protein] synthase activity. Predicted to be involved in acyl-CoA metabolic process; medium-chain fatty acid biosynthetic process; and short-chain fatty acid biosynthetic process. Located in mitochondrion. Is expressed in dorsal root ganglion; lung; nervous system; peripheral nervous system; and respiratory system. Orthologous to human OXSM (3-oxoacyl-ACP synthase, mitochondrial). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in kidney adult (RPKM 4.1), testis adult (RPKM 3.8) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 14 A1; 14 7.08 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (6219955..6231111)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (16238652..16249808, complement)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

LA (alpha-lipoic acid) deficiency was observed with a reduction in lipoylation of pyruvate dehydrogenase in the kidney of streptozotocin-induced diabetic mice. Proteins of three enzymes (MCAT, OXSM and LIAS) in the LA synthetic pathway were examined in the kidney. A reduction was observed in OXSM, but not in the other two.
Title: Reduction of mitochondrial 3-oxoacyl-ACP synthase (OXSM) by hyperglycemia is associated with deficiency of α-lipoic acid synthetic pathway in kidney of diabetic mice.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Gene trapped (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Oxsm (e-PCR), detects polymorphism
- UniSTS:546911

RH126934 (e-PCR)
- UniSTS:209766

NoName (e-PCR)
- UniSTS:488836

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 3-oxoacyl-[acyl-carrier-protein] synthase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 3-oxoacyl-[acyl-carrier-protein] synthase activity	ISO Inferred from Sequence Orthology more info
enables 3-oxoacyl-[acyl-carrier-protein] synthase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in acyl-CoA metabolic process	ISO Inferred from Sequence Orthology more info
involved_in acyl-CoA metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in fatty acid biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in medium-chain fatty acid biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in medium-chain fatty acid biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in short-chain fatty acid biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in short-chain fatty acid biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: 3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial

Names: beta-ketoacyl-ACP synthase

NP_001346811.1

EC 2.3.1.41

NP_001346812.1

EC 2.3.1.41

NP_081971.1

EC 2.3.1.41

XP_006518164.1

EC 2.3.1.41

XP_006518165.1

EC 2.3.1.41

XP_006518166.1

EC 2.3.1.41

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001359882.1 → NP_001346811.1 3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial precursor

Status: VALIDATED

Source sequence(s)

AC173482, AK016905, AK034243, BG229916

Consensus CDS

CCDS26831.1

UniProtKB/Swiss-Prot

Q9D404

UniProtKB/TrEMBL

Q148P2

Conserved Domains (1) summary

cd00834
Location:42 → 456

KAS_I_II; Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen ...
NM_001359883.1 → NP_001346812.1 3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial precursor

Status: VALIDATED

Source sequence(s)

AC173482, AK034243, AK084829, BG229916

Consensus CDS

CCDS26831.1

UniProtKB/Swiss-Prot

Q9D404

UniProtKB/TrEMBL

Q148P2

Related

ENSMUSP00000108244.2, ENSMUST00000112625.9

Conserved Domains (1) summary

cd00834
Location:42 → 456

KAS_I_II; Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen ...
NM_027695.4 → NP_081971.1 3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial precursor

See identical proteins and their annotated locations for NP_081971.1

Status: VALIDATED

Source sequence(s)

AC173482, AK034243, AK083617, BG229916

Consensus CDS

CCDS26831.1

UniProtKB/Swiss-Prot

Q9D404

UniProtKB/TrEMBL

Q148P2

Related

ENSMUSP00000022311.5, ENSMUST00000022311.12

Conserved Domains (1) summary

cd00834
Location:42 → 456

KAS_I_II; Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000080.7 Reference GRCm39 C57BL/6J

Range

6219955..6231111

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006518101.4 → XP_006518164.1 3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial isoform X1

See identical proteins and their annotated locations for XP_006518164.1

UniProtKB/Swiss-Prot

Q9D404

UniProtKB/TrEMBL

Q148P2

Related

ENSMUSP00000108243.2, ENSMUST00000112624.3

Conserved Domains (1) summary

cd00834
Location:42 → 456

KAS_I_II; Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen ...
XM_006518103.5 → XP_006518166.1 3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial isoform X1

See identical proteins and their annotated locations for XP_006518166.1

UniProtKB/Swiss-Prot

Q9D404

UniProtKB/TrEMBL

Q148P2

Conserved Domains (1) summary

cd00834
Location:42 → 456

KAS_I_II; Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen ...
XM_006518102.2 → XP_006518165.1 3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial isoform X1

See identical proteins and their annotated locations for XP_006518165.1

UniProtKB/Swiss-Prot

Q9D404

UniProtKB/TrEMBL

Q148P2

Conserved Domains (1) summary

cd00834
Location:42 → 456

KAS_I_II; Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen ...