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TNFAIP3 TNF alpha induced protein 3 [ Homo sapiens (human) ]

Gene ID: 7128, updated on 27-Nov-2024

Summary

Official Symbol
TNFAIP3provided by HGNC
Official Full Name
TNF alpha induced protein 3provided by HGNC
Primary source
HGNC:HGNC:11896
See related
Ensembl:ENSG00000118503 MIM:191163; AllianceGenome:HGNC:11896
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
A20; AISBL; AIFBL1; OTUD7C; TNFA1P2
Summary
This gene was identified as a gene whose expression is rapidly induced by the tumor necrosis factor (TNF). The protein encoded by this gene is a zinc finger protein and ubiqitin-editing enzyme, and has been shown to inhibit NF-kappa B activation as well as TNF-mediated apoptosis. The encoded protein, which has both ubiquitin ligase and deubiquitinase activities, is involved in the cytokine-mediated immune and inflammatory responses. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2012]
Expression
Broad expression in bone marrow (RPKM 156.2), appendix (RPKM 61.9) and 14 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See TNFAIP3 in Genome Data Viewer
Location:
6q23.3
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (137866349..137883312)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (139054729..139071725)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (138188396..138204449)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17586 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:138039958-138040164 Neighboring gene PTPN11 pseudogene 3 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17587 Neighboring gene long intergenic non-protein coding RNA 2539 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17588 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25145 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25146 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25147 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25148 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25149 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25150 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25151 Neighboring gene wound and keratinocyte migration associated lncRNA 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25152 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17589 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25153 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17590 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17591 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25154 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr6:138196296-138197495 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:138200115-138200697 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25155 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25156 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr6:138246817-138248016 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25157 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17592 Neighboring gene NANOG hESC enhancer GRCh37_chr6:138276502-138277003 Neighboring gene long intergenic non-protein coding RNA 2865 Neighboring gene suppressor of inflammatory macrophage apoptosis lncRNA Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25158 Neighboring gene ribosomal protein SA pseudogene 42

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Autoinflammatory syndrome, familial, Behcet-like 1
MedGen: C4225218 OMIM: 616744 GeneReviews: Not available
Compare labs

EBI GWAS Catalog

Description
A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1.
EBI GWAS Catalog
A genome-wide association study in Han Chinese identifies a susceptibility locus for primary Sjögren's syndrome at 7q11.23.
EBI GWAS Catalog
A regulatory variant in CCR6 is associated with rheumatoid arthritis susceptibility.
EBI GWAS Catalog
A systemic sclerosis and systemic lupus erythematosus pan-meta-GWAS reveals new shared susceptibility loci.
EBI GWAS Catalog
Association of genome-wide variation with highly sensitive cardiac troponin-T levels in European Americans and Blacks: a meta-analysis from atherosclerosis risk in communities and cardiovascular health studies.
EBI GWAS Catalog
Genetic variants near TNFAIP3 on 6q23 are associated with systemic lupus erythematosus.
EBI GWAS Catalog
Genetics of rheumatoid arthritis contributes to biology and drug discovery.
EBI GWAS Catalog
Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus.
EBI GWAS Catalog
Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci.
EBI GWAS Catalog
Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways.
EBI GWAS Catalog
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
EBI GWAS Catalog
Meta-analysis followed by replication identifies loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with systemic lupus erythematosus in Asians.
EBI GWAS Catalog
Multiple common variants for celiac disease influencing immune gene expression.
EBI GWAS Catalog
Novel rheumatoid arthritis susceptibility locus at 22q12 identified in an extended UK genome-wide association study.
EBI GWAS Catalog
Two independent alleles at 6q23 associated with risk of rheumatoid arthritis.
EBI GWAS Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 and the viral protein Tat modulate the expression of tumor necrosis factor, alpha-induced protein 3 (TNFAIP3) in immature dendritic cells and monocyte-derived macrophages PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC104522, MGC138687, MGC138688

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables K63-linked deubiquitinase activity EXP
Inferred from Experiment
more info
PubMed 
enables K63-linked deubiquitinase activity TAS
Traceable Author Statement
more info
 
enables K63-linked polyubiquitin modification-dependent protein binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables cysteine-type deubiquitinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables cysteine-type deubiquitinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables cysteine-type deubiquitinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables cysteine-type deubiquitinase activity TAS
Traceable Author Statement
more info
PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables kinase binding IEA
Inferred from Electronic Annotation
more info
 
enables protease binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ubiquitin binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ubiquitin-protein transferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in B-1 B cell homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in cell migration IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cellular response to hydrogen peroxide ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cellular response to lipopolysaccharide IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in establishment of protein localization to vacuole IEA
Inferred from Electronic Annotation
more info
 
involved_in inflammatory response IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of B cell activation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of CD40 signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of NF-kappaB transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of bone resorption NAS
Non-traceable Author Statement
more info
PubMed 
involved_in negative regulation of canonical NF-kappaB signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of chronic inflammatory response IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of endothelial cell apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of extrinsic apoptotic signaling pathway via death domain receptors IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of inflammatory response ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of innate immune response ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within negative regulation of interleukin-1 beta production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of interleukin-2 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of interleukin-6 production ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of osteoclast proliferation NAS
Non-traceable Author Statement
more info
PubMed 
involved_in negative regulation of protein ubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of smooth muscle cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of toll-like receptor 2 signaling pathway NAS
Non-traceable Author Statement
more info
PubMed 
involved_in negative regulation of toll-like receptor 3 signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of toll-like receptor 4 signaling pathway NAS
Non-traceable Author Statement
more info
PubMed 
involved_in negative regulation of toll-like receptor 5 signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of tumor necrosis factor production ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway TAS
Traceable Author Statement
more info
 
involved_in positive regulation of Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of hepatocyte proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of protein catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein K11-linked deubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein K48-linked deubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein K48-linked ubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein K63-linked deubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein deubiquitination TAS
Traceable Author Statement
more info
PubMed 
involved_in protein deubiquitination involved in ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of defense response to virus by host NAS
Non-traceable Author Statement
more info
PubMed 
involved_in regulation of germinal center formation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of tumor necrosis factor-mediated signaling pathway TAS
Traceable Author Statement
more info
 
involved_in regulation of vascular wound healing NAS
Non-traceable Author Statement
more info
PubMed 
involved_in response to molecule of bacterial origin IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to muramyl dipeptide IEA
Inferred from Electronic Annotation
more info
 
involved_in tolerance induction to lipopolysaccharide IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in extracellular exosome HDA PubMed 
located_in lysosome IEA
Inferred from Electronic Annotation
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
tumor necrosis factor alpha-induced protein 3
Names
OTU domain-containing protein 7C
putative DNA-binding protein A20
tumor necrosis factor inducible protein A20
tumor necrosis factor, alpha induced protein 3
zinc finger protein A20
NP_001257436.1
NP_001257437.1
NP_006281.1
XP_005267176.1
XP_011534397.1
XP_011534398.1
XP_024302300.1
XP_024302301.1
XP_047275238.1
XP_047275239.1
XP_047275240.1
XP_047275241.1
XP_054212262.1
XP_054212263.1
XP_054212264.1
XP_054212265.1
XP_054212266.1
XP_054212267.1
XP_054212268.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_032761.1 RefSeqGene

    Range
    4816..20869
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001270507.2NP_001257436.1  tumor necrosis factor alpha-induced protein 3

    See identical proteins and their annotated locations for NP_001257436.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.
    Source sequence(s)
    CB528739, DB143089, M59465
    Consensus CDS
    CCDS5187.1
    UniProtKB/Swiss-Prot
    B2R767, E1P588, P21580, Q2HIX9, Q5VXQ7, Q9NSR6
    UniProtKB/TrEMBL
    D3TTZ3, D3TTZ4
    Related
    ENSP00000401562.2, ENST00000420009.6
    Conserved Domains (2) summary
    smart00259
    Location:759784
    ZnF_A20; A20-like zinc fingers
    pfam02338
    Location:98257
    OTU; OTU-like cysteine protease
  2. NM_001270508.2NP_001257437.1  tumor necrosis factor alpha-induced protein 3

    See identical proteins and their annotated locations for NP_001257437.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. All three variants encode the same protein.
    Source sequence(s)
    CB528739, HY009939, M59465
    Consensus CDS
    CCDS5187.1
    UniProtKB/Swiss-Prot
    B2R767, E1P588, P21580, Q2HIX9, Q5VXQ7, Q9NSR6
    UniProtKB/TrEMBL
    D3TTZ3, D3TTZ4
    Related
    ENSP00000481570.1, ENST00000612899.5
    Conserved Domains (2) summary
    smart00259
    Location:759784
    ZnF_A20; A20-like zinc fingers
    pfam02338
    Location:98257
    OTU; OTU-like cysteine protease
  3. NM_006290.4NP_006281.1  tumor necrosis factor alpha-induced protein 3

    See identical proteins and their annotated locations for NP_006281.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.
    Source sequence(s)
    CB528739, HY085289, M59465
    Consensus CDS
    CCDS5187.1
    UniProtKB/Swiss-Prot
    B2R767, E1P588, P21580, Q2HIX9, Q5VXQ7, Q9NSR6
    UniProtKB/TrEMBL
    D3TTZ3, D3TTZ4
    Related
    ENSP00000237289.4, ENST00000237289.8
    Conserved Domains (2) summary
    smart00259
    Location:759784
    ZnF_A20; A20-like zinc fingers
    pfam02338
    Location:98257
    OTU; OTU-like cysteine protease

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    137866349..137883312
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047419283.1XP_047275239.1  tumor necrosis factor alpha-induced protein 3 isoform X2

    UniProtKB/Swiss-Prot
    B2R767, E1P588, P21580, Q2HIX9, Q5VXQ7, Q9NSR6
  2. XM_011536095.2XP_011534397.1  tumor necrosis factor alpha-induced protein 3 isoform X2

    See identical proteins and their annotated locations for XP_011534397.1

    UniProtKB/Swiss-Prot
    B2R767, E1P588, P21580, Q2HIX9, Q5VXQ7, Q9NSR6
    UniProtKB/TrEMBL
    D3TTZ3, D3TTZ4
    Conserved Domains (2) summary
    smart00259
    Location:759784
    ZnF_A20; A20-like zinc fingers
    pfam02338
    Location:98257
    OTU; OTU-like cysteine protease
  3. XM_024446533.2XP_024302301.1  tumor necrosis factor alpha-induced protein 3 isoform X2

    UniProtKB/Swiss-Prot
    B2R767, E1P588, P21580, Q2HIX9, Q5VXQ7, Q9NSR6
    UniProtKB/TrEMBL
    D3TTZ3, D3TTZ4
    Conserved Domains (2) summary
    smart00259
    Location:759784
    ZnF_A20; A20-like zinc fingers
    pfam02338
    Location:98257
    OTU; OTU-like cysteine protease
  4. XM_011536096.3XP_011534398.1  tumor necrosis factor alpha-induced protein 3 isoform X3

    UniProtKB/TrEMBL
    D3TTZ2
    Conserved Domains (2) summary
    smart00259
    Location:475500
    ZnF_A20; A20-like zinc fingers
    pfam02338
    Location:98257
    OTU; OTU-like cysteine protease
  5. XM_047419285.1XP_047275241.1  tumor necrosis factor alpha-induced protein 3 isoform X3

  6. XM_047419284.1XP_047275240.1  tumor necrosis factor alpha-induced protein 3 isoform X3

  7. XM_024446532.2XP_024302300.1  tumor necrosis factor alpha-induced protein 3 isoform X2

    UniProtKB/Swiss-Prot
    B2R767, E1P588, P21580, Q2HIX9, Q5VXQ7, Q9NSR6
    UniProtKB/TrEMBL
    D3TTZ3, D3TTZ4
    Conserved Domains (2) summary
    smart00259
    Location:759784
    ZnF_A20; A20-like zinc fingers
    pfam02338
    Location:98257
    OTU; OTU-like cysteine protease
  8. XM_047419282.1XP_047275238.1  tumor necrosis factor alpha-induced protein 3 isoform X1

    Related
    ENSP00000409845.2, ENST00000433680.2
  9. XM_005267119.1XP_005267176.1  tumor necrosis factor alpha-induced protein 3 isoform X2

    See identical proteins and their annotated locations for XP_005267176.1

    UniProtKB/Swiss-Prot
    B2R767, E1P588, P21580, Q2HIX9, Q5VXQ7, Q9NSR6
    UniProtKB/TrEMBL
    D3TTZ3, D3TTZ4
    Conserved Domains (2) summary
    smart00259
    Location:759784
    ZnF_A20; A20-like zinc fingers
    pfam02338
    Location:98257
    OTU; OTU-like cysteine protease

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    139054729..139071725
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054356288.1XP_054212263.1  tumor necrosis factor alpha-induced protein 3 isoform X2

    UniProtKB/Swiss-Prot
    B2R767, E1P588, P21580, Q2HIX9, Q5VXQ7, Q9NSR6
  2. XM_054356289.1XP_054212264.1  tumor necrosis factor alpha-induced protein 3 isoform X2

    UniProtKB/Swiss-Prot
    B2R767, E1P588, P21580, Q2HIX9, Q5VXQ7, Q9NSR6
  3. XM_054356291.1XP_054212266.1  tumor necrosis factor alpha-induced protein 3 isoform X3

  4. XM_054356293.1XP_054212268.1  tumor necrosis factor alpha-induced protein 3 isoform X3

  5. XM_054356292.1XP_054212267.1  tumor necrosis factor alpha-induced protein 3 isoform X3

  6. XM_054356287.1XP_054212262.1  tumor necrosis factor alpha-induced protein 3 isoform X2

    UniProtKB/Swiss-Prot
    B2R767, E1P588, P21580, Q2HIX9, Q5VXQ7, Q9NSR6
  7. XM_054356290.1XP_054212265.1  tumor necrosis factor alpha-induced protein 3 isoform X2

    UniProtKB/Swiss-Prot
    B2R767, E1P588, P21580, Q2HIX9, Q5VXQ7, Q9NSR6