Arhgap21 Rho GTPase activating protein 21 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Arhgap21provided by MGI
Official Full Name: Rho GTPase activating protein 21provided by MGI
Primary source: MGI:MGI:1918685
See related: Ensembl:ENSMUSG00000036591 AllianceGenome:MGI:1918685
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: ARHGAP10; 5530401C11Rik
Summary: Predicted to enable GTPase activator activity. Acts upstream of or within regulation of endocytosis. Located in plasma membrane. Is expressed in central nervous system; dorsal root ganglion; and neural retina. Orthologous to human ARHGAP21 (Rho GTPase activating protein 21). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in cerebellum adult (RPKM 9.5), CNS E14 (RPKM 6.4) and 26 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 A3; 2 14.6 cM

Exon count:: 30

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (20852746..20973761, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (20847919..20968691, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Deficiency of ARHGAP21 alters megakaryocytic cell lineage responses and enhances platelet hemostatic function.
Title: Deficiency of ARHGAP21 alters megakaryocytic cell lineage responses and enhances platelet hemostatic function.
liver of ARHGAP21-haplodeficient mice are more insulin sensitive, associated with higher lipid synthesis and lower lipid export
Title: ARHGAP21 deficiency impairs hepatic lipid metabolism and improves insulin signaling in lean and obese mice.
the whole body ARHGAP21 reduction improved glucose homeostasis and protected against diet-induced obesity.
Title: Whole body ARHGAP21 reduction improves glucose homeostasis in high-fat diet obese mice.
Reduced Arhgap21 is associated with Hematopoietic defects.
Title: Hematopoietic defects in response to reduced Arhgap21.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Gene trapped (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH124540 (e-PCR)
- UniSTS:161362

NoName (e-PCR)
- UniSTS:234332

D2Mit6 (e-PCR), detects polymorphism
- UniSTS:129455

RH134054 (e-PCR)
- UniSTS:217336

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GTPase activator activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in Golgi localization	IBA Inferred from Biological aspect of Ancestor more info
involved_in Golgi organization	ISO Inferred from Sequence Orthology more info
involved_in establishment of Golgi localization	ISO Inferred from Sequence Orthology more info
involved_in maintenance of Golgi location	ISO Inferred from Sequence Orthology more info
involved_in organelle transport along microtubule	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
located_in actin cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in anchoring junction	IEA Inferred from Electronic Annotation more info
located_in cell junction	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic vesicle membrane	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: rho GTPase-activating protein 21

Names: rho GTPase-activating protein 10; rho-type GTPase-activating protein 21

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001081364.4 → NP_001074833.3 rho GTPase-activating protein 21 isoform 2

See identical proteins and their annotated locations for NP_001074833.3

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an in-frame exon in the coding region, compared to variant 1. It encodes isoform 2 which is shorter than isoform 1.

Source sequence(s)

AL773540, AL929100, BX649226

Consensus CDS

CCDS38054.2

UniProtKB/TrEMBL

B2RWX1, B7ZCJ0

Related

ENSMUSP00000133851.2, ENSMUST00000173194.8

Conserved Domains (3) summary

cd00992
Location:54 → 161

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd04395
Location:1138 → 1333

RhoGAP_ARHGAP21; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the cell-cell junction ...

cd01253
Location:927 → 1036

PH_ARHGAP21-like; ARHGAP21 and related proteins pleckstrin homology (PH) domain
NM_001128084.3 → NP_001121556.2 rho GTPase-activating protein 21 isoform 1

See identical proteins and their annotated locations for NP_001121556.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AL773540, AL929100, BX649226

Consensus CDS

CCDS50512.1

UniProtKB/TrEMBL

B2RWX1, B7ZCJ1

Related

ENSMUSP00000120357.3, ENSMUST00000141298.9

Conserved Domains (3) summary

cd00992
Location:54 → 161

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd04395
Location:1148 → 1343

RhoGAP_ARHGAP21; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the cell-cell junction ...

cd01253
Location:937 → 1046

PH_ARHGAP21-like; ARHGAP21 and related proteins pleckstrin homology (PH) domain
NM_001408319.1 → NP_001395248.1 rho GTPase-activating protein 21 isoform 1

Status: VALIDATED

Source sequence(s)

AL773540, AL929100, BX649226

UniProtKB/TrEMBL

B7ZCJ1
NM_001408320.1 → NP_001395249.1 rho GTPase-activating protein 21 isoform 2

Status: VALIDATED

Source sequence(s)

AL773540, AL929100, BX649226

UniProtKB/TrEMBL

B7ZCJ0
NM_001408321.1 → NP_001395250.1 rho GTPase-activating protein 21 isoform 3

Status: VALIDATED

Source sequence(s)

AL929100, BX649226
NM_001408322.1 → NP_001395251.1 rho GTPase-activating protein 21 isoform 4

Status: VALIDATED

Source sequence(s)

AL929100, BX649226
NM_001408323.1 → NP_001395252.1 rho GTPase-activating protein 21 isoform 5

Status: VALIDATED

Source sequence(s)

AL773540, AL929100, BX649226
NM_001408324.1 → NP_001395253.1 rho GTPase-activating protein 21 isoform 6

Status: VALIDATED

Source sequence(s)

AL773540, AL929100, BX649226

Related

ENSMUSP00000133347.2, ENSMUST00000174584.8
NM_001408325.1 → NP_001395254.1 rho GTPase-activating protein 21 isoform 7

Status: VALIDATED

Source sequence(s)

BX649226

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

20852746..20973761 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030252084.2 → XP_030107944.1 rho GTPase-activating protein 21 isoform X6

UniProtKB/TrEMBL

B2RWX1

Conserved Domains (3) summary

cd00992
Location:54 → 161

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd04395
Location:1139 → 1334

RhoGAP_ARHGAP21; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the cell-cell junction ...

cd01253
Location:927 → 1036

PH_ARHGAP21-like; ARHGAP21 and related proteins pleckstrin homology (PH) domain
XM_006497540.5 → XP_006497603.1 rho GTPase-activating protein 21 isoform X2

See identical proteins and their annotated locations for XP_006497603.1

UniProtKB/TrEMBL

B2RWX1

Conserved Domains (3) summary

cd00992
Location:54 → 161

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd04395
Location:1149 → 1344

RhoGAP_ARHGAP21; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the cell-cell junction ...

cd01253
Location:937 → 1046

PH_ARHGAP21-like; ARHGAP21 and related proteins pleckstrin homology (PH) domain
XM_006497539.5 → XP_006497602.1 rho GTPase-activating protein 21 isoform X2

See identical proteins and their annotated locations for XP_006497602.1

UniProtKB/TrEMBL

B2RWX1

Conserved Domains (3) summary

cd00992
Location:54 → 161

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd04395
Location:1149 → 1344

RhoGAP_ARHGAP21; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the cell-cell junction ...

cd01253
Location:937 → 1046

PH_ARHGAP21-like; ARHGAP21 and related proteins pleckstrin homology (PH) domain
XM_006497541.4 → XP_006497604.1 rho GTPase-activating protein 21 isoform X2

See identical proteins and their annotated locations for XP_006497604.1

UniProtKB/TrEMBL

B2RWX1

Conserved Domains (3) summary

cd00992
Location:54 → 161

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd04395
Location:1149 → 1344

RhoGAP_ARHGAP21; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the cell-cell junction ...

cd01253
Location:937 → 1046

PH_ARHGAP21-like; ARHGAP21 and related proteins pleckstrin homology (PH) domain
XM_006497542.5 → XP_006497605.1 rho GTPase-activating protein 21 isoform X3

UniProtKB/TrEMBL

A0A0A0MQE8

Conserved Domains (3) summary

cd00992
Location:55 → 162

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd04395
Location:1149 → 1344

RhoGAP_ARHGAP21; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the cell-cell junction ...

cd01253
Location:938 → 1047

PH_ARHGAP21-like; ARHGAP21 and related proteins pleckstrin homology (PH) domain
XM_017319262.3 → XP_017174751.1 rho GTPase-activating protein 21 isoform X10

UniProtKB/TrEMBL

G3UWM5

Conserved Domains (3) summary

cd00992
Location:55 → 162

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd04395
Location:1149 → 1344

RhoGAP_ARHGAP21; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the cell-cell junction ...

cd01253
Location:938 → 1047

PH_ARHGAP21-like; ARHGAP21 and related proteins pleckstrin homology (PH) domain
XM_006497538.5 → XP_006497601.1 rho GTPase-activating protein 21 isoform X1

UniProtKB/TrEMBL

A0A0A0MQE8

Conserved Domains (3) summary

cd00992
Location:55 → 162

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd04395
Location:1150 → 1345

RhoGAP_ARHGAP21; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the cell-cell junction ...

cd01253
Location:938 → 1047

PH_ARHGAP21-like; ARHGAP21 and related proteins pleckstrin homology (PH) domain
XM_011238986.4 → XP_011237288.1 rho GTPase-activating protein 21 isoform X9

UniProtKB/TrEMBL

G3UWM5

Conserved Domains (3) summary

cd00992
Location:55 → 162

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd04395
Location:1150 → 1345

RhoGAP_ARHGAP21; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the cell-cell junction ...

cd01253
Location:938 → 1047

PH_ARHGAP21-like; ARHGAP21 and related proteins pleckstrin homology (PH) domain
XM_017319263.3 → XP_017174752.1 rho GTPase-activating protein 21 isoform X11

UniProtKB/TrEMBL

G3UWM5

Conserved Domains (3) summary

cd00992
Location:55 → 162

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd01253
Location:938 → 1047

PH_ARHGAP21-like; ARHGAP21 and related proteins pleckstrin homology (PH) domain

cl02570
Location:1150 → 1271

RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...