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Zfp935 zinc finger protein 935 [ Mus musculus (house mouse) ]

Gene ID: 71508, updated on 4-Jan-2025

Summary

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Official Symbol
Zfp935provided by MGI
Official Full Name
zinc finger protein 935provided by MGI
Primary source
MGI:MGI:1918758
See related
Ensembl:ENSMUSG00000113450 AllianceGenome:MGI:1918758
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Es113; Gm49359; 8430426H19Rik
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleolus. Orthologous to several human genes including ZNF486 (zinc finger protein 486); ZNF506 (zinc finger protein 506); and ZNF679 (zinc finger protein 679). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Broad expression in bladder adult (RPKM 2.6), placenta adult (RPKM 2.3) and 20 other tissues See more
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Genomic context

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See Zfp935 in Genome Data Viewer
Location:
13; 13 B3
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (62600830..62614626, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (62453016..62466852, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene predicted gene 3604 Neighboring gene STARR-seq mESC enhancer starr_34771 Neighboring gene selenoprotein K, pseudogene 6 Neighboring gene predicted gene, 53788 Neighboring gene STARR-positive B cell enhancer ABC_E7245 Neighboring gene predicted gene, 21145 Neighboring gene STARR-seq mESC enhancer starr_34772 Neighboring gene protein C1orf43 homolog Neighboring gene zinc finger protein 934

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518
  2. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
  3. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
  4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC107309, MGC132990

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
KRAB zinc finger protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001136496.1 → NP_001129968.1  KRAB zinc finger protein isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) is missing an internal coding exon compared to transcript variant 1. This result in a frame-shift, and a shorter isoform (2) with a distinct C-terminus compared to isoform 1. Isoform 2 retains the 'KRAB' domain at the N-terminus.
    Source sequence(s)
    AK018441, BC087936
    Consensus CDS
    CCDS88469.1
    UniProtKB/TrEMBL
    A0A1Y7VP04
    Related
    ENSMUSP00000152739.2, ENSMUST00000223247.2
    Conserved Domains (2) summary
    smart00349
    Location:4 → 44
    KRAB; krueppel associated box
    pfam01352
    Location:4 → 40
    KRAB; KRAB box

  2. NM_178875.4 → NP_849206.2  KRAB zinc finger protein isoform 1

    See identical proteins and their annotated locations for NP_849206.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1) containing the 'KRAB' domain at the N-terminus and the Zn-finger domain at the C-terminus.
    Source sequence(s)
    BC087936, BC113193
    Consensus CDS
    CCDS36697.1
    UniProtKB/TrEMBL
    Q14DI0
    Related
    ENSMUSP00000152662.2, ENSMUST00000221747.2
    Conserved Domains (5) summary
    smart00349
    Location:4 → 45
    KRAB; krueppel associated box
    COG5048
    Location:130 → 293
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:219 → 239
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:4 → 40
    KRAB; KRAB box
    pfam13465
    Location:175 → 200
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    62600830..62614626 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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