Clmp CXADR-like membrane protein [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Clmpprovided by MGI
Official Full Name: CXADR-like membrane proteinprovided by MGI
Primary source: MGI:MGI:1918816
See related: Ensembl:ENSMUSG00000032024 AllianceGenome:MGI:1918816
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: ACAM; ASP5; 9030425E11Rik
Summary: Involved in postsynaptic modulation of chemical synaptic transmission. Is active in postsynaptic membrane. Is expressed in brain. Human ortholog(s) of this gene implicated in short bowel syndrome. Orthologous to human CLMP (CXADR like membrane protein). [provided by Alliance of Genome Resources, Jan 2025]
Expression: Broad expression in bladder adult (RPKM 13.4), CNS E18 (RPKM 13.4) and 21 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 A5.1; 9 21.42 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (40596975..40696849)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (40682123..40785553)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CXADR-like membrane protein protects against heart injury by preventing excessive pyroptosis after myocardial infarction.
Title: CXADR-like membrane protein protects against heart injury by preventing excessive pyroptosis after myocardial infarction.
Enhanced expression of coxsackievirus and adenovirus receptor in lipopolysaccharide-induced inflammatory macrophages is through TRIF-dependent innate immunity pathway.
Title: Enhanced expression of coxsackievirus and adenovirus receptor in lipopolysaccharide-induced inflammatory macrophages is through TRIF-dependent innate immunity pathway.
the levels of mRNAs encoding Connexin43 or Connexin45 were not or were only marginally affected, respectively, by Clmp deficiency, the absence of CLMP caused a severe reduction of both proteins in smooth muscle cells of the intestine and of Connexin43 in the ureter.
Title: The IgCAM CLMP regulates expression of Connexin43 and Connexin45 in intestinal and ureteral smooth muscle contraction in mice.
Data (including data from studies in transgenic mice) suggest that, when Acam/Clmp is abundantly expressed on plasma membrane of mature adipocytes, mice are protected from obesity and diabetes with prominent reduction of adipose tissue mass and smaller size of adipocytes; studies used high-fat, high-sucrose diet to induce obesity and diabetes in control mice.
Title: Antiobesity Action of ACAM by Modulating the Dynamics of Cell Adhesion and Actin Polymerization in Adipocytes.
TNFalpha-mediated mRNA degradation of the CLMP gene is controlled by TTP through the JNK signalling cascade
Title: Post-transcriptional regulation of CLMP mRNA is controlled by tristetraprolin in response to TNFalpha via c-Jun N-terminal kinase signalling.
Expression of CLMP, a novel tight junction protein, is mediated via the interaction of GATA with the Kruppel family proteins, KLF4 and Sp1, in mouse TM4 Sertoli cells.
Title: Expression of CLMP, a novel tight junction protein, is mediated via the interaction of GATA with the Kruppel family proteins, KLF4 and Sp1, in mouse TM4 Sertoli cells.
We identified ACAM (adipocyte adhesion molecule), a novel homologue of the CTX (cortical thymocyte marker in Xenopus) gene family, which may be the critical adhesion molecule in adipocyte differentiation and development of obesity.
Title: Identification of adipocyte adhesion molecule (ACAM), a novel CTX gene family, implicated in adipocyte maturation and development of obesity.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:236105

AW557819 (e-PCR)
- UniSTS:179877

D9Mit253 (e-PCR), detects polymorphism
- UniSTS:131824

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in digestive tract development	IEA Inferred from Electronic Annotation more info
involved_in digestive tract development	ISO Inferred from Sequence Orthology more info
involved_in postsynaptic modulation of chemical synaptic transmission	IDA Inferred from Direct Assay more info	PubMed
involved_in postsynaptic modulation of chemical synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in bicellular tight junction	IEA Inferred from Electronic Annotation more info
located_in bicellular tight junction	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic microtubule	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic microtubule	ISS Inferred from Sequence or Structural Similarity more info
is_active_in postsynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic membrane	IMP Inferred from Mutant Phenotype more info	PubMed

General protein information

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Preferred Names: CXADR-like membrane protein

Names: CAR-like membrane protein; adipocyte adhesion molecule; adipocyte-specific protein 5; coxsackie- and adenovirus receptor-like membrane protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_133733.5 → NP_598494.2 CXADR-like membrane protein precursor

See identical proteins and their annotated locations for NP_598494.2

Status: VALIDATED

Source sequence(s)

AC140409, AC158355

Consensus CDS

CCDS23082.1

UniProtKB/Swiss-Prot

Q8R373, Q920S5

Related

ENSMUSP00000034522.8, ENSMUST00000034522.8

Conserved Domains (2) summary

smart00410
Location:143 → 224

IG_like; Immunoglobulin like

pfam07686
Location:28 → 128

V-set; Immunoglobulin V-set domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000075.7 Reference GRCm39 C57BL/6J

Range

40596975..40696849

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006510602.5 → XP_006510665.1 CXADR-like membrane protein isoform X1

Conserved Domains (2) summary

smart00409
Location:169 → 250

IG; Immunoglobulin

pfam07686
Location:54 → 154

V-set; Immunoglobulin V-set domain
XM_006510603.3 → XP_006510666.1 CXADR-like membrane protein isoform X2

Conserved Domains (2) summary

smart00409
Location:142 → 223

IG; Immunoglobulin

pfam07686
Location:27 → 127

V-set; Immunoglobulin V-set domain