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Brox BRO1 domain and CAAX motif containing [ Mus musculus (house mouse) ]

Gene ID: 71678, updated on 27-Nov-2024

Summary

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Official Symbol
Broxprovided by MGI
Official Full Name
BRO1 domain and CAAX motif containingprovided by MGI
Primary source
MGI:MGI:1918928
See related
Ensembl:ENSMUSG00000046836 AllianceGenome:MGI:1918928
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
0610010K06Rik
Summary
Predicted to be involved in mitotic nuclear membrane reassembly. Predicted to be located in nuclear envelope. Orthologous to human BROX (BRO1 domain and CAAX motif containing). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in CNS E18 (RPKM 25.6), whole brain E14.5 (RPKM 20.8) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Brox in Genome Data Viewer
Location:
1; 1 H5
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (183057916..183078839, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (183276352..183297298, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene dispatched RND transporter family member 1 Neighboring gene protein phosphatase 2A inhibitor-2 I-2PP2A-related Neighboring gene family with sequence similarity 177 member B Neighboring gene predicted gene, 34287 Neighboring gene axin interactor, dorsalization associated Neighboring gene MIA SH3 domain ER export factor 3 Neighboring gene predicted gene, 34102 Neighboring gene protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting, 4 (parvulin) pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Brox, a novel farnesylated Bro1 domain-containing protein that associates with charged multivesicular body protein 4 (CHMP4). Ichioka F, et al. FEBS J, 2008 Feb. PMID 18190528
  2. The sperm-associated antigen 6 interactome and its role in spermatogenesis. Liu Y, et al. Reproduction, 2019 Aug. PMID 31146259, Free PMC Article
  3. Transcriptome analysis of mouse stem cells and early embryos. Sharov AA, et al. PLoS Biol, 2003 Dec. PMID 14691545, Free PMC Article
  4. Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette. Taniwaki T, et al. Dev Growth Differ, 2005 Apr. PMID 15840001
  5. Exchangeable gene trap using the Cre/mutated lox system. Araki K, et al. Cell Mol Biol (Noisy-le-grand), 1999 Jul. PMID 10512203

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in mitotic nuclear membrane reassembly ISO
Inferred from Sequence Orthology
more info
  
involved_in mitotic nuclear membrane reassembly ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in nuclear envelope ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear envelope ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nuclear membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
BRO1 domain-containing protein BROX
Names
BRO1 domain- and CAAX motif-containing protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357242.2 → NP_001344171.1  BRO1 domain-containing protein BROX

    Status: VALIDATED

    Source sequence(s)
    AEKQ02108040, CAAA01119163
    Consensus CDS
    CCDS56662.1
    UniProtKB/Swiss-Prot
    Q8BWM8, Q8K2Q7, Q9DCT7
    Related
    ENSMUSP00000132333.4, ENSMUST00000163528.8
    Conserved Domains (1) summary
    cd09243
    Location:4 → 356
    BRO1_Brox_like; Protein-interacting Bro1-like domain of human Brox1 and related proteins

  2. NM_027861.4 → NP_082137.1  BRO1 domain-containing protein BROX

    See identical proteins and their annotated locations for NP_082137.1

    Status: VALIDATED

    Source sequence(s)
    AEKQ02108040, CAAA01119163
    Consensus CDS
    CCDS56662.1
    UniProtKB/Swiss-Prot
    Q8BWM8, Q8K2Q7, Q9DCT7
    Related
    ENSMUSP00000061345.6, ENSMUST00000057062.12
    Conserved Domains (1) summary
    cd09243
    Location:4 → 356
    BRO1_Brox_like; Protein-interacting Bro1-like domain of human Brox1 and related proteins

RNA

  1. NR_151660.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AEKQ02108040, CAAA01119163

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    183057916..183078839 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006535600.5 → XP_006535663.1  BRO1 domain-containing protein BROX isoform X3

    Conserved Domains (1) summary
    cl14649
    Location:1 → 243
    BRO1_Alix_like; Protein-interacting Bro1-like domain of mammalian Alix and related domains

  2. XM_006535599.5 → XP_006535662.1  BRO1 domain-containing protein BROX isoform X2

    Conserved Domains (1) summary
    cd09243
    Location:1 → 300
    BRO1_Brox_like; Protein-interacting Bro1-like domain of human Brox1 and related proteins

  3. XM_036153688.1 → XP_036009581.1  BRO1 domain-containing protein BROX isoform X3

    Conserved Domains (1) summary
    cl14649
    Location:1 → 243
    BRO1_Alix_like; Protein-interacting Bro1-like domain of mammalian Alix and related domains

  4. XM_030243025.1 → XP_030098885.1  BRO1 domain-containing protein BROX isoform X2

    Conserved Domains (1) summary
    cd09243
    Location:1 → 300
    BRO1_Brox_like; Protein-interacting Bro1-like domain of human Brox1 and related proteins

  5. XM_006535598.4 → XP_006535661.1  BRO1 domain-containing protein BROX isoform X1

    See identical proteins and their annotated locations for XP_006535661.1

    UniProtKB/Swiss-Prot
    Q8BWM8, Q8K2Q7, Q9DCT7
    Conserved Domains (1) summary
    cd09243
    Location:4 → 356
    BRO1_Brox_like; Protein-interacting Bro1-like domain of human Brox1 and related proteins

RNA

  1. XR_389720.5 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8K2Q7.1 GenPept UniProtKB/Swiss-Prot:Q8K2Q7

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