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TPO thyroid peroxidase [ Homo sapiens (human) ]

Gene ID: 7173, updated on 27-Nov-2024

Summary

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Official Symbol
TPOprovided by HGNC
Official Full Name
thyroid peroxidaseprovided by HGNC
Primary source
HGNC:HGNC:12015
See related
Ensembl:ENSG00000115705 MIM:606765; AllianceGenome:HGNC:12015
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MSA; TPX; TDH2A
Summary
This gene encodes a membrane-bound glycoprotein. The encoded protein acts as an enzyme and plays a central role in thyroid gland function. The protein functions in the iodination of tyrosine residues in thyroglobulin and phenoxy-ester formation between pairs of iodinated tyrosines to generate the thyroid hormones, thyroxine and triiodothyronine. Mutations in this gene are associated with several disorders of thyroid hormonogenesis, including congenital hypothyroidism, congenital goiter, and thyroid hormone organification defect IIA. Multiple transcript variants encoding distinct isoforms have been identified for this gene, but the full-length nature of some variants has not been determined. [provided by RefSeq, May 2011]
Annotation information
Note: TPO (Gene ID: 7173) and THPO (Gene ID: 7066) share the TPO symbol/alias in common. TPO is a widely used alternative name for thrombopoietin (THPO), which can be confused with the official symbol for TPO, thyroid peroxidase. [27 Jun 2018]
Expression
Restricted expression toward thyroid (RPKM 463.8) See more
Orthologs
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Genomic context

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See TPO in Genome Data Viewer
Location:
2p25.3
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (1374047..1543673)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (1414928..1549090)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (1417235..1547445)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene syntrophin gamma 2 Neighboring gene uncharacterized LOC124905965 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:1260844-1260999 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr2:1265169-1266368 Neighboring gene Sharpr-MPRA regulatory region 1386 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:1309663-1310386 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:1310387-1311109 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:1312058-1312678 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:1312679-1313298 Neighboring gene uncharacterized LOC105373359 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:1370519-1371072 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr2:1391744-1392312 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:1407339-1407839 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr2:1421072-1422271 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:1451513-1452123 Neighboring gene uncharacterized LOC124905966 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:1492359-1492916 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:1492917-1493474 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:1499759-1500394 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:1519727-1520228 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr2:1544276-1545475 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11103 Neighboring gene uncharacterized LOC102723730 Neighboring gene NANOG hESC enhancer GRCh37_chr2:1575946-1576447 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:1586454-1586968 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:1586969-1587483 Neighboring gene uncharacterized LOC124907722 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:1594967-1595486 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:1595487-1596006 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:1596007-1596524

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. The efficacy of the thyroid peroxidase marker for distinguishing follicular thyroid carcinoma from follicular adenoma. Savin S, et al. Exp Oncol, 2006 Mar. PMID 16614712
  2. Value of combined clinical information and thyroid peroxidase antibodies in pregnancy for the prediction of postpartum thyroid dysfunction. Mamede da Costa S, et al. Am J Reprod Immunol, 2007 Oct. PMID 17845204
  3. Effects of 12 months treatment with L-selenomethionine on serum anti-TPO Levels in Patients with Hashimoto's thyroiditis. Mazokopakis EE, et al. Thyroid, 2007 Jul. PMID 17696828
  4. Two compound heterozygous mutations (c.215delA/c.2422T-->C and c.387delC/c.1159G-->A) in the thyroid peroxidase gene responsible for congenital goitre and iodide organification defect. Rivolta CM, et al. Clin Endocrinol (Oxf), 2007 Aug. PMID 17547680
  5. High prevalence of thyroid peroxidase gene mutations in patients with thyroid dyshormonogenesis. Avbelj M, et al. Eur J Endocrinol, 2007 May. PMID 17468186

See all (184) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Disulfide Bonds of Thyroid Peroxidase Are Critical Elements for Subcellular Localization, Proteasome-Dependent Degradation, and Enzyme Activity.
    Title: Disulfide Bonds of Thyroid Peroxidase Are Critical Elements for Subcellular Localization, Proteasome-Dependent Degradation, and Enzyme Activity.
  2. Is There a Link between Thyroid Peroxidase Gene Promoter Polymorphisms and Autoimmune Thyroiditis in the Polish Population?
    Title: Is There a Link between Thyroid Peroxidase Gene Promoter Polymorphisms and Autoimmune Thyroiditis in the Polish Population?
  3. Homozygous Mutations in Thyroid Peroxidase (TPO) in Hypothyroidism with Intellectual Disability, Developmental Delay, and Hearing and Ocular Anomalies in Two Families: Severe Manifestation of Untreated TPO-deficiency Poses a Diagnostic Dilemma.
    Title: Homozygous Mutations in Thyroid Peroxidase (TPO) in Hypothyroidism with Intellectual Disability, Developmental Delay, and Hearing and Ocular Anomalies in Two Families: Severe Manifestation of Untreated TPO-deficiency Poses a Diagnostic Dilemma.
  4. TPO as an indicator of lymph node metastasis and recurrence in papillary thyroid carcinoma.
    Title: TPO as an indicator of lymph node metastasis and recurrence in papillary thyroid carcinoma.
  5. Variants in TPO rs2048722, PTCSC2 rs925489 and SEMA4G rs4919510 affect thyroid carcinoma susceptibility risk.
    Title: Variants in TPO rs2048722, PTCSC2 rs925489 and SEMA4G rs4919510 affect thyroid carcinoma susceptibility risk.
  6. Longitudinal Associations Between TPO Gene Variants and Thyroid Peroxidase Antibody Seroconversion in a Population-Based Study: Tehran Thyroid Study.
    Title: Longitudinal Associations Between TPO Gene Variants and Thyroid Peroxidase Antibody Seroconversion in a Population-Based Study: Tehran Thyroid Study.
  7. Cryo-electron microscopy structures of human thyroid peroxidase (TPO) in complex with TPO antibodies.
    Title: Cryo-electron microscopy structures of human thyroid peroxidase (TPO) in complex with TPO antibodies.
  8. Hypomethylation of Thyroid Peroxidase as a Biomarker for Hepatocellular Carcinoma with Tumor Thrombosis.
    Title: Hypomethylation of Thyroid Peroxidase as a Biomarker for Hepatocellular Carcinoma with Tumor Thrombosis.
  9. Mutational screening of the TPO and DUOX2 genes in Argentinian children with congenital hypothyroidism due to thyroid dyshormonogenesis.
    Title: Mutational screening of the TPO and DUOX2 genes in Argentinian children with congenital hypothyroidism due to thyroid dyshormonogenesis.
  10. TSH stimulation of human thyroglobulin and thyroid peroxidase gene transcription is partially dependent on internalization.
    Title: TSH stimulation of human thyroglobulin and thyroid peroxidase gene transcription is partially dependent on internalization.
Submit: New GeneRIF Correction See all GeneRIFs (134)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Deficiency of iodide peroxidase
MedGen: C1291299 OMIM: 274500 GeneReviews: Not available
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EBI GWAS Catalog

Description
A genome-wide association study on thyroid function and anti-thyroid peroxidase antibodies in Koreans.
EBI GWAS Catalog
Genome-wide association study of peripheral neuropathy with D-drug-containing regimens in AIDS Clinical Trials Group protocol 384.
EBI GWAS Catalog
Identification of novel genetic Loci associated with thyroid peroxidase antibodies and clinical thyroid disease.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables heme binding IEA
Inferred from Electronic Annotation
more info
  
enables iodide peroxidase activity IEA
Inferred from Electronic Annotation
more info
  
enables peroxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables peroxidase activity TAS
Traceable Author Statement
more info
  
Process Evidence Code Pubs
involved_in cellular oxidant detoxification IEA
Inferred from Electronic Annotation
more info
  
involved_in embryonic hemopoiesis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in hormone biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in hydrogen peroxide catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in response to oxidative stress IEA
Inferred from Electronic Annotation
more info
  
involved_in thyroid hormone generation IEA
Inferred from Electronic Annotation
more info
  
involved_in thyroid hormone generation TAS
Traceable Author Statement
more info
  
Component Evidence Code Pubs
located_in cell surface IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular space HDA PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
thyroid peroxidase
Names
thyroid microsomal antigen
thyroperoxidase
NP_000538.3
NP_001193673.1
NP_001193674.1
NP_783650.1
NP_783652.1
NP_783653.1
XP_011508682.2
XP_024308853.1
XP_024308855.1
XP_024308856.1
XP_024308857.1
XP_024308858.1
XP_024308859.1
XP_024308860.1
XP_024308861.1
XP_047301608.1
XP_047301609.1
XP_047301610.1
XP_047301611.1
XP_047301612.1
XP_047301613.1
XP_054199614.1
XP_054199615.1
XP_054199616.1
XP_054199617.1
XP_054199618.1
XP_054199619.1
XP_054199620.1
XP_054199621.1
XP_054199622.1
XP_054199623.1
XP_054199624.1
XP_054199625.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_011581.2 RefSeqGene

    Range
    44418..174628
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000547.6 → NP_000538.3  thyroid peroxidase isoform a precursor

    See identical proteins and their annotated locations for NP_000538.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a, also known as TPO1).
    Source sequence(s)
    AC141930, AW874082, BC063107, BC095448, J02969
    Consensus CDS
    CCDS1643.1
    UniProtKB/Swiss-Prot
    P07202, P09934, P09935, Q8IUL0, Q8NF94, Q8NF95, Q8NF96, Q8NF97, Q8TCI9
    UniProtKB/TrEMBL
    Q502Y3
    Related
    ENSP00000318820.7, ENST00000345913.8
    Conserved Domains (3) summary
    cd00033
    Location:742 → 795
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    cd09825
    Location:167 → 734
    thyroid_peroxidase; Thyroid peroxidase (TPO)
    pfam07645
    Location:796 → 838
    EGF_CA; Calcium-binding EGF domain

  2. NM_001206744.2 → NP_001193673.1  thyroid peroxidase isoform a precursor

    See identical proteins and their annotated locations for NP_001193673.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) lacks a segment in the 5' UTR and encodes the same isoform (a, also known as TPO1), compared to variant 1.
    Source sequence(s)
    AC141930, BC095448, Y00406
    Consensus CDS
    CCDS1643.1
    UniProtKB/Swiss-Prot
    P07202, P09934, P09935, Q8IUL0, Q8NF94, Q8NF95, Q8NF96, Q8NF97, Q8TCI9
    UniProtKB/TrEMBL
    Q502Y3
    Related
    ENSP00000329869.4, ENST00000329066.9
    Conserved Domains (3) summary
    cd00033
    Location:742 → 795
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    cd09825
    Location:167 → 734
    thyroid_peroxidase; Thyroid peroxidase (TPO)
    pfam07645
    Location:796 → 838
    EGF_CA; Calcium-binding EGF domain

  3. NM_001206745.2 → NP_001193674.1  thyroid peroxidase isoform b precursor

    See identical proteins and their annotated locations for NP_001193674.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) lacks a segment in the 5' UTR and an in-frame exon in the central coding region, compared to variant 1, resulting in an isoform (b, also known as TPO2) that is shorter than isoform a.
    Source sequence(s)
    AC141930, BC063107, BE046044, J02969, X17358
    Consensus CDS
    CCDS1644.1
    UniProtKB/TrEMBL
    Q502Y3
    Conserved Domains (4) summary
    cd00033
    Location:685 → 738
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    cd09825
    Location:167 → 677
    thyroid_peroxidase; Thyroid peroxidase (TPO)
    pfam03098
    Location:151 → 642
    An_peroxidase; Animal haem peroxidase
    pfam07645
    Location:739 → 781
    EGF_CA; Calcium-binding EGF domain

  4. NM_175719.4 → NP_783650.1  thyroid peroxidase isoform b precursor

    See identical proteins and their annotated locations for NP_783650.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an an alternate in-frame exon in the central coding region, compared to variant 1, resulting in an isoform (b, also known as TPO2) that is shorter than isoform a.
    Source sequence(s)
    AC141930, AW874082, BC063107, BC095448, J02970
    Consensus CDS
    CCDS1644.1
    UniProtKB/TrEMBL
    Q502Y3
    Related
    ENSP00000371636.3, ENST00000382201.7
    Conserved Domains (4) summary
    cd00033
    Location:685 → 738
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    cd09825
    Location:167 → 677
    thyroid_peroxidase; Thyroid peroxidase (TPO)
    pfam03098
    Location:151 → 642
    An_peroxidase; Animal haem peroxidase
    pfam07645
    Location:739 → 781
    EGF_CA; Calcium-binding EGF domain

  5. NM_175721.3 → NP_783652.1  thyroid peroxidase isoform d precursor

    See identical proteins and their annotated locations for NP_783652.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an in-frame segment of the coding region, compared to variant 1. It encodes a shorter isoform (d, also known as TPO4) compared to isoform a. This variant lacks the 5'-most non-coding exon because of alternate splicing, the extension at the 5' end is uncertain.
    Source sequence(s)
    AW874082, AY136822, CB986756, DA958481, M55702, X17358, Y00406
    UniProtKB/TrEMBL
    Q502Y3
    Related
    ENSP00000263886.6, ENST00000346956.7
    Conserved Domains (3) summary
    cd00033
    Location:742 → 795
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    cd09825
    Location:167 → 734
    thyroid_peroxidase; Thyroid peroxidase (TPO)
    pfam03098
    Location:151 → 699
    An_peroxidase; Animal haem peroxidase

  6. NM_175722.3 → NP_783653.1  thyroid peroxidase isoform e precursor

    See identical proteins and their annotated locations for NP_783653.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks an alternate in-frame exon in the central coding region, compared to variant 1, resulting in an isoform (e, also known as TPO5) that is shorter than isoform a. This variant lacks the 5'-most non-coding exon because of alternate splicing, the extension at the 5' end is uncertain.
    Source sequence(s)
    AF439430, AF533528, AW874082, BC095448, CD608890, DA958481
    Consensus CDS
    CCDS1646.1
    UniProtKB/TrEMBL
    Q502Y3
    Related
    ENSP00000371633.1, ENST00000382198.5
    Conserved Domains (4) summary
    cd00033
    Location:569 → 622
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    cl14561
    Location:1 → 561
    An_peroxidase_like; Animal heme peroxidases and related proteins
    pfam03098
    Location:151 → 526
    An_peroxidase; Animal haem peroxidase
    pfam07645
    Location:623 → 665
    EGF_CA; Calcium-binding EGF domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    1374047..1543673
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047445652.1 → XP_047301608.1  thyroid peroxidase isoform X3

  2. XM_047445655.1 → XP_047301611.1  thyroid peroxidase isoform X3

  3. XM_047445654.1 → XP_047301610.1  thyroid peroxidase isoform X3

  4. XM_047445656.1 → XP_047301612.1  thyroid peroxidase isoform X3

  5. XM_047445653.1 → XP_047301609.1  thyroid peroxidase isoform X3

  6. XM_024453089.2 → XP_024308857.1  thyroid peroxidase isoform X3

    UniProtKB/TrEMBL
    H0Y6H4
    Conserved Domains (2) summary
    cd00033
    Location:742 → 795
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    cd09825
    Location:167 → 734
    thyroid_peroxidase; Thyroid peroxidase (TPO)

  7. XM_011510380.4 → XP_011508682.2  thyroid peroxidase isoform X2

    UniProtKB/TrEMBL
    Q53QT2
    Conserved Domains (3) summary
    cd00033
    Location:754 → 807
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    cd09825
    Location:179 → 746
    thyroid_peroxidase; Thyroid peroxidase (TPO)
    pfam07645
    Location:808 → 850
    EGF_CA; Calcium-binding EGF domain

  8. XM_024453090.2 → XP_024308858.1  thyroid peroxidase isoform X4

    UniProtKB/TrEMBL
    Q502Y3
    Conserved Domains (2) summary
    cd00033
    Location:754 → 807
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    cd09825
    Location:179 → 746
    thyroid_peroxidase; Thyroid peroxidase (TPO)

  9. XM_047445657.1 → XP_047301613.1  thyroid peroxidase isoform X5

  10. XM_024453091.2 → XP_024308859.1  thyroid peroxidase isoform X6

    UniProtKB/TrEMBL
    Q502Y3
    Conserved Domains (3) summary
    cd00033
    Location:697 → 750
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    cd09825
    Location:179 → 689
    thyroid_peroxidase; Thyroid peroxidase (TPO)
    pfam07645
    Location:751 → 793
    EGF_CA; Calcium-binding EGF domain

  11. XM_024453092.2 → XP_024308860.1  thyroid peroxidase isoform X7

    UniProtKB/TrEMBL
    Q502Y3
    Conserved Domains (2) summary
    cd00033
    Location:697 → 750
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    cd09825
    Location:179 → 689
    thyroid_peroxidase; Thyroid peroxidase (TPO)

  12. XM_024453093.2 → XP_024308861.1  thyroid peroxidase isoform X8

    UniProtKB/TrEMBL
    Q502Y3
    Conserved Domains (3) summary
    cd00033
    Location:581 → 634
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    pfam07645
    Location:635 → 677
    EGF_CA; Calcium-binding EGF domain
    cl14561
    Location:13 → 573
    An_peroxidase_like; Animal heme peroxidases and related proteins

  13. XM_024453085.2 → XP_024308853.1  thyroid peroxidase isoform X1

    UniProtKB/TrEMBL
    H0Y6H4
    Conserved Domains (2) summary
    cd00033
    Location:754 → 807
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    cd09825
    Location:179 → 746
    thyroid_peroxidase; Thyroid peroxidase (TPO)

  14. XM_024453088.2 → XP_024308856.1  thyroid peroxidase isoform X3

    UniProtKB/TrEMBL
    H0Y6H4
    Conserved Domains (2) summary
    cd00033
    Location:742 → 795
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    cd09825
    Location:167 → 734
    thyroid_peroxidase; Thyroid peroxidase (TPO)

  15. XM_024453087.2 → XP_024308855.1  thyroid peroxidase isoform X3

    UniProtKB/TrEMBL
    H0Y6H4
    Related
    ENSP00000405788.1, ENST00000422464.5
    Conserved Domains (2) summary
    cd00033
    Location:742 → 795
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    cd09825
    Location:167 → 734
    thyroid_peroxidase; Thyroid peroxidase (TPO)

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NT_187529.1 Reference GRCh38.p14 ALT_REF_LOCI_1

    Range
    96661..223095
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    1414928..1549090
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054343642.1 → XP_054199617.1  thyroid peroxidase isoform X10

  2. XM_054343640.1 → XP_054199615.1  thyroid peroxidase isoform X10

  3. XM_054343641.1 → XP_054199616.1  thyroid peroxidase isoform X10

  4. XM_054343646.1 → XP_054199621.1  thyroid peroxidase isoform X13

  5. XM_054343645.1 → XP_054199620.1  thyroid peroxidase isoform X12

  6. XM_054343650.1 → XP_054199625.1  thyroid peroxidase isoform X15

  7. XM_054343643.1 → XP_054199618.1  thyroid peroxidase isoform X1

  8. XM_054343639.1 → XP_054199614.1  thyroid peroxidase isoform X9

  9. XM_054343647.1 → XP_054199622.1  thyroid peroxidase isoform X14

  10. XM_054343648.1 → XP_054199623.1  thyroid peroxidase isoform X4

  11. XM_054343644.1 → XP_054199619.1  thyroid peroxidase isoform X11

  12. XM_054343649.1 → XP_054199624.1  thyroid peroxidase isoform X6

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_175720.1: Suppressed sequence

    Description
    NM_175720.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P07202.4 GenPept UniProtKB/Swiss-Prot:P07202

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