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Syce2 synaptonemal complex central element protein 2 [ Mus musculus (house mouse) ]

Gene ID: 71846, updated on 4-Jan-2025

Summary

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Official Symbol
Syce2provided by MGI
Official Full Name
synaptonemal complex central element protein 2provided by MGI
Primary source
MGI:MGI:1919096
See related
Ensembl:ENSMUSG00000003824 AllianceGenome:MGI:1919096
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cesc1; 1700013H19Rik
Summary
Predicted to be involved in cell division. Predicted to act upstream of or within synaptonemal complex assembly. Located in central element. Is expressed in primary spermatocyte and spermatocyte. Orthologous to human SYCE2 (synaptonemal complex central element protein 2). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in testis adult (RPKM 31.9), liver E14 (RPKM 10.9) and 11 other tissues See more
Orthologs
human all
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Genomic context

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See Syce2 in Genome Data Viewer
Location:
8 C3; 8 41.25 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (85598740..85614075)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (84872111..84887446)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700122E12 gene Neighboring gene predicted gene 5911 Neighboring gene phenylalanyl-tRNA synthetase, alpha subunit Neighboring gene STARR-positive B cell enhancer ABC_E11391 Neighboring gene microRNA 7069 Neighboring gene glutaryl-Coenzyme A dehydrogenase Neighboring gene STARR-positive B cell enhancer ABC_E1763 Neighboring gene predicted gene, 39213 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:87427053-87427162 Neighboring gene Kruppel-like transcription factor 1 (erythroid)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. SYCE2 is required for synaptonemal complex assembly, double strand break repair, and homologous recombination. Bolcun-Filas E, et al. J Cell Biol, 2007 Mar 12. PMID 17339376, Free PMC Article
  2. Elucidation of synaptonemal complex organization by super-resolution imaging with isotropic resolution. Schücker K, et al. Proc Natl Acad Sci U S A, 2015 Feb 17. PMID 25646409, Free PMC Article
  3. Phylogenies of central element proteins reveal the dynamic evolutionary history of the mammalian synaptonemal complex: ancient and recent components. Fraune J, et al. Genetics, 2013 Nov. PMID 24026100, Free PMC Article
  4. The Zip4 protein directly couples meiotic crossover formation to synaptonemal complex assembly. Pyatnitskaya A, et al. Genes Dev, 2022 Jan 1. PMID 34969823, Free PMC Article
  5. Two novel proteins recruited by synaptonemal complex protein 1 (SYCP1) are at the centre of meiosis. Costa Y, et al. J Cell Sci, 2005 Jun 15. PMID 15944401

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SLX2 interacts with synaptonemal complex central element protein 2 (SYCE2), an important component of synaptonemal complex.
    Title: SYCP3-like X-linked 2 is expressed in meiotic germ cells and interacts with synaptonemal complex central element protein 2 and histone acetyltransferase TIP60.
  2. Synaptonemal complex assembly is dependent on SYCE2.
    Title: SYCE2 is required for synaptonemal complex assembly, double strand break repair, and homologous recombination.
  3. The localisation of Syce1 and Cesc1 (Syce2) to the central element depends on recruitment by Sycp1.
    Title: Two novel proteins recruited by synaptonemal complex protein 1 (SYCP1) are at the centre of meiosis.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Gene trapped (1)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within synaptonemal complex assembly IC
Inferred by Curator
more info
 PubMed 
Component Evidence Code Pubs
is_active_in central element IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in central element IDA
Inferred from Direct Assay
more info
 PubMed 
located_in chromosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in synaptonemal complex ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
synaptonemal complex central element protein 2
Names
central element synaptonemal complex 1
central element synaptonemal complex protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001168244.1 → NP_001161716.1  synaptonemal complex central element protein 2 isoform 3

    See identical proteins and their annotated locations for NP_001161716.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and 5' coding region and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
    Source sequence(s)
    AC161765, AK082833, AK167332
    UniProtKB/Swiss-Prot
    Q505B8

  2. NM_001168246.1 → NP_001161718.1  synaptonemal complex central element protein 2 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC161765
    Consensus CDS
    CCDS52620.1
    UniProtKB/TrEMBL
    A2RTK0, E9PYH4
    Related
    ENSMUSP00000131438.2, ENSMUST00000170296.2

  3. NM_027954.3 → NP_082230.2  synaptonemal complex central element protein 2 isoform 2

    See identical proteins and their annotated locations for NP_082230.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1
    Source sequence(s)
    AC161765, AK005954, AK082833, BY246600
    Consensus CDS
    CCDS22481.1
    UniProtKB/Swiss-Prot
    Q3TJR1, Q505B8, Q9DAC4
    UniProtKB/TrEMBL
    A2RTK0
    Related
    ENSMUSP00000122159.2, ENSMUST00000136026.8

RNA

  1. NR_031759.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC161765, AK082833, BY083329
    Related
    ENSMUST00000003922.6

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    85598740..85614075
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q505B8.1 GenPept UniProtKB/Swiss-Prot:Q505B8

Gene LinkOut

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