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Apol9b apolipoprotein L 9b [ Mus musculus (house mouse) ]

Gene ID: 71898, updated on 27-Nov-2024

Summary

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Official Symbol
Apol9bprovided by MGI
Official Full Name
apolipoprotein L 9bprovided by MGI
Primary source
MGI:MGI:1919148
See related
Ensembl:ENSMUSG00000068246 AllianceGenome:MGI:1919148
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2310016F22Rik
Summary
Predicted to enable chloride channel activity and lipid binding activity. Predicted to be located in extracellular space. Predicted to be part of high-density lipoprotein particle and very-low-density lipoprotein particle. Human ortholog(s) of this gene implicated in schizophrenia. Orthologous to human APOL1 (apolipoprotein L1) and APOL2 (apolipoprotein L2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in liver adult (RPKM 51.5), small intestine adult (RPKM 29.9) and 2 other tissues See more
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Genomic context

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See Apol9b in Genome Data Viewer
Location:
15 E1; 15 36.75 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (77613248..77620582)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (77729047..77736382)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene apolipoprotein L 7e Neighboring gene predicted gene, 18911 Neighboring gene predicted gene, 36329 Neighboring gene apolipoprotein L 8 Neighboring gene myosin, heavy polypeptide 9, non-muscle Neighboring gene VISTA enhancer mm1644 Neighboring gene STARR-seq mESC enhancer starr_39115 Neighboring gene STARR-seq mESC enhancer starr_39117 Neighboring gene STARR-positive B cell enhancer ABC_E8905 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:77664820-77665003 Neighboring gene predicted gene, 22107

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Inefficient type I interferon-mediated antiviral protection of primary mouse neurons is associated with the lack of apolipoprotein l9 expression. Kreit M, et al. J Virol, 2014 Apr. PMID 24453359, Free PMC Article
  2. Mouse screen reveals multiple new genes underlying mouse and human hearing loss. Ingham NJ, et al. PLoS Biol, 2019 Apr. PMID 30973865, Free PMC Article
  3. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
  4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Authors identified a new antiviral protein induced by interferon, ApoL9b, whose lack of expression in primary neurons likely contributes to the high sensitivity of these cells to viral infection.
    Title: Inefficient type I interferon-mediated antiviral protection of primary mouse neurons is associated with the lack of apolipoprotein l9 expression.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (1) 

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables chloride channel activity ISO
Inferred from Sequence Orthology
more info
  
enables lipid binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables lipid binding ISO
Inferred from Sequence Orthology
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
  
part_of high-density lipoprotein particle ISO
Inferred from Sequence Orthology
more info
  
part_of very-low-density lipoprotein particle ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
apolipoprotein L 9b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001168660.1 → NP_001162131.1  apolipoprotein L 9b

    See identical proteins and their annotated locations for NP_001162131.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants encode the same protein.
    Source sequence(s)
    AK009386, BF148017
    Consensus CDS
    CCDS27604.1
    UniProtKB/TrEMBL
    D3Z501, Q6PF90, Q8C7I4
    Related
    ENSMUSP00000105397.3, ENSMUST00000109775.4
    Conserved Domains (1) summary
    pfam05461
    Location:1 → 310
    ApoL; Apolipoprotein L

  2. NM_173743.4 → NP_776104.1  apolipoprotein L 9b

    See identical proteins and their annotated locations for NP_776104.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses a different splice site and segment for its 5' UTR compared to variant 1. Both variants encode the same protein.
    Source sequence(s)
    AK050167, BF148017
    Consensus CDS
    CCDS27604.1
    UniProtKB/TrEMBL
    D3Z501, Q6PF90, Q8C7I4
    Related
    ENSMUSP00000155314.2, ENSMUST00000230979.2
    Conserved Domains (1) summary
    pfam05461
    Location:1 → 310
    ApoL; Apolipoprotein L

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    77613248..77620582
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030248781.2 → XP_030104641.1  apolipoprotein L 9b isoform X1

    UniProtKB/TrEMBL
    D3Z501, Q6PF90, Q8C7I4
    Conserved Domains (1) summary
    pfam05461
    Location:1 → 310
    ApoL; Apolipoprotein L
Nucleotide Protein Strain
Heading Accession and Version

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