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C3AR1 complement C3a receptor 1 [ Homo sapiens (human) ]

Gene ID: 719, updated on 27-Nov-2024

Summary

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Official Symbol
C3AR1provided by HGNC
Official Full Name
complement C3a receptor 1provided by HGNC
Primary source
HGNC:HGNC:1319
See related
Ensembl:ENSG00000171860 MIM:605246; AllianceGenome:HGNC:1319
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AZ3B; C3AR; HNFAG09
Summary
C3a is an anaphylatoxin released during activation of the complement system. The protein encoded by this gene is an orphan G protein-coupled receptor for C3a. Binding of C3a by the encoded receptor activates chemotaxis, granule enzyme release, superoxide anion production, and bacterial opsonization. [provided by RefSeq, May 2016]
Expression
Broad expression in appendix (RPKM 43.3), placenta (RPKM 19.2) and 21 other tissues See more
Orthologs
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Genomic context

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See C3AR1 in Genome Data Viewer
Location:
12p13.31
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (8056844..8066359, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (8070449..8079963, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (8209440..8218955, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene heat shock protein family D (Hsp60) member 1 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5924 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4206 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4207 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5925 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5926 Neighboring gene forkhead box J2 Neighboring gene NANOG hESC enhancer GRCh37_chr12:8229725-8230226 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr12:8234132-8235331 Neighboring gene NECAP endocytosis associated 1 Neighboring gene C-type lectin domain family 4 member A Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5929 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:8286281-8287059 Neighboring gene POU class 5 homeobox 1 pseudogene 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. cDNA cloning of a novel G protein-coupled receptor with a large extracellular loop structure. Roglic A, et al. Biochim Biophys Acta, 1996 Feb 7. PMID 8605247
  2. Decreased expression of complement 3a receptor (C3aR) in human placentas from severe preeclamptic pregnancies. Lim R, et al. Eur J Obstet Gynecol Reprod Biol, 2012 Dec. PMID 22901903
  3. C3aR1 gene overexpressed at initial stage of acute myeloid leukemia-M2 predicting short-term survival. Wu SY, et al. Leuk Lymphoma, 2015 Jul. PMID 25426664
  4. The TLQP-21 peptide activates the G-protein-coupled receptor C3aR1 via a folding-upon-binding mechanism. Cero C, et al. Structure, 2014 Dec 2. PMID 25456411, Free PMC Article
  5. Regulation of C3a receptor signaling in human mast cells by G protein coupled receptor kinases. Guo Q, et al. PLoS One, 2011. PMID 21799898, Free PMC Article

See all (78) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Complement 3a induces the synapse loss via C3aR in mitochondria-dependent NLRP3 activating mechanisms during the development and progression of Alzheimer's disease.
    Title: Complement 3a induces the synapse loss via C3aR in mitochondria-dependent NLRP3 activating mechanisms during the development and progression of Alzheimer's disease.
  2. C3aR-initiated signaling is a critical mechanism of podocyte injury in membranous nephropathy.
    Title: C3aR-initiated signaling is a critical mechanism of podocyte injury in membranous nephropathy.
  3. Deficiency of Complement C3a and C5a receptors Does Not Prevent Angiotensin II-Induced Hypertension and Hypertensive End-Organ Damage.
    Title: Deficiency of Complement C3a and C5a receptors Does Not Prevent Angiotensin II-Induced Hypertension and Hypertensive End-Organ Damage.
  4. Molecular signatures of intrarenal complement receptors C3AR1 and C5AR1 correlate with renal outcome in human lupus nephritis.
    Title: Molecular signatures of intrarenal complement receptors C3AR1 and C5AR1 correlate with renal outcome in human lupus nephritis.
  5. The Complement C3a-C3a Receptor Axis Regulates Epithelial-to-Mesenchymal Transition by Activating the ERK Pathway in Pancreatic Ductal Adenocarcinoma.
    Title: The Complement C3a-C3a Receptor Axis Regulates Epithelial-to-Mesenchymal Transition by Activating the ERK Pathway in Pancreatic Ductal Adenocarcinoma.
  6. Identification and characterization of prognosis-related genes in the tumor microenvironment of esophageal squamous cell carcinoma.
    Title: Identification and characterization of prognosis-related genes in the tumor microenvironment of esophageal squamous cell carcinoma.
  7. Down-Regulation of C3aR/C5aR Inhibits Cell Proliferation and EMT in Hepatocellular Carcinoma.
    Title: Down-Regulation of C3aR/C5aR Inhibits Cell Proliferation and EMT in Hepatocellular Carcinoma.
  8. Mitochondrial C3a Receptor Activation in Oxidatively Stressed Epithelial Cells Reduces Mitochondrial Respiration and Metabolism.
    Title: Mitochondrial C3a Receptor Activation in Oxidatively Stressed Epithelial Cells Reduces Mitochondrial Respiration and Metabolism.
  9. Changes in VGF and C3aR1 gene expression in human adipose tissue in obesity.
    Title: Changes in VGF and C3aR1 gene expression in human adipose tissue in obesity.
  10. High Expression of the Component 3a Receptor 1 (C3AR1) Gene in Stomach Adenocarcinomas Infers a Poor Prognosis and High Immune-Infiltration Levels.
    Title: High Expression of the Component 3a Receptor 1 (C3AR1) Gene in Stomach Adenocarcinomas Infers a Poor Prognosis and High Immune-Infiltration Levels.
Submit: New GeneRIF Correction See all GeneRIFs (49)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See Variation Viewer (GRCh37.p13)

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Vpr vpr HIV-1 Vpr upregulates the gene expression of C3AR1 in human monocyte-derived dendritic cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables G protein-coupled receptor activity IPI
Inferred from Physical Interaction
more info
 PubMed 
enables complement component C3a receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables complement component C3a receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables complement component C5a receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 PubMed 
involved_in blood circulation TAS
Traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within_positive_effect calcium-mediated signaling IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within_positive_effect calcium-mediated signaling IPI
Inferred from Physical Interaction
more info
 PubMed 
involved_in chemotaxis IEA
Inferred from Electronic Annotation
more info
  
involved_in complement component C5a signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in complement receptor mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in complement receptor mediated signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of angiogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of cytosolic calcium ion concentration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of macrophage chemotaxis IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of neutrophil chemotaxis IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of vascular endothelial growth factor production IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in azurophil granule membrane TAS
Traceable Author Statement
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  
located_in specific granule membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
C3a anaphylatoxin chemotactic receptor
Names
complement component 3 receptor 1
complement component 3a receptor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_050736.1 RefSeqGene

    Range
    5113..14628
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001326475.2 → NP_001313404.1  C3a anaphylatoxin chemotactic receptor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.
    Source sequence(s)
    AC006511, BU074964, DB274838
    Consensus CDS
    CCDS8588.1
    UniProtKB/Swiss-Prot
    O43771, Q16581, Q92868
    UniProtKB/TrEMBL
    A8K2H7, Q53FA1
    Conserved Domains (1) summary
    cd15115
    Location:24 → 446
    7tmA_C3aR; complement component 3a anaphylatoxin chemotactic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors

  2. NM_001326477.2 → NP_001313406.1  C3a anaphylatoxin chemotactic receptor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.
    Source sequence(s)
    AC006511, BU074964, DA351375, DB013722
    Consensus CDS
    CCDS8588.1
    UniProtKB/Swiss-Prot
    O43771, Q16581, Q92868
    UniProtKB/TrEMBL
    A8K2H7, Q53FA1
    Conserved Domains (1) summary
    cd15115
    Location:24 → 446
    7tmA_C3aR; complement component 3a anaphylatoxin chemotactic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors

  3. NM_004054.4 → NP_004045.1  C3a anaphylatoxin chemotactic receptor

    See identical proteins and their annotated locations for NP_004045.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the predominant transcript. All three variants encode the same protein.
    Source sequence(s)
    AC006511, BC020742, BU074964
    Consensus CDS
    CCDS8588.1
    UniProtKB/Swiss-Prot
    O43771, Q16581, Q92868
    UniProtKB/TrEMBL
    A8K2H7, Q53FA1
    Related
    ENSP00000302079.4, ENST00000307637.5
    Conserved Domains (1) summary
    cd15115
    Location:24 → 446
    7tmA_C3aR; complement component 3a anaphylatoxin chemotactic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    8056844..8066359 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    8070449..8079963 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q16581.2 GenPept UniProtKB/Swiss-Prot:Q16581

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