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Ist1 increased sodium tolerance 1 homolog (yeast) [ Mus musculus (house mouse) ]

Gene ID: 71955, updated on 27-Nov-2024

Summary

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Official Symbol
Ist1provided by MGI
Official Full Name
increased sodium tolerance 1 homolog (yeast)provided by MGI
Primary source
MGI:MGI:1919205
See related
Ensembl:ENSMUSG00000031729 AllianceGenome:MGI:1919205
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CHMP8; mKIAA0174; 2400003C14Rik
Summary
Predicted to enable MIT domain binding activity and identical protein binding activity. Acts upstream of or within positive regulation of collateral sprouting. Predicted to be located in several cellular components, including Flemming body; endoplasmic reticulum-Golgi intermediate compartment; and extracellular exosome. Is expressed in several structures, including branchial arch; limb bud; nervous system; sensory organ; and tooth. Orthologous to human IST1 (IST1 factor associated with ESCRT-III). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in CNS E14 (RPKM 40.7), CNS E18 (RPKM 40.3) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Ist1 in Genome Data Viewer
Location:
8 D3; 8 57.18 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (110397953..110419929, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (109671321..109693297, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 39247 Neighboring gene dihydroorotate dehydrogenase Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:112132543-112132726 Neighboring gene polycystic kidney disease 1 like 3 Neighboring gene STARR-positive B cell enhancer ABC_E3805 Neighboring gene zinc finger protein 821 Neighboring gene predicted gene, 53453 Neighboring gene ataxin 1-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Reduced circ_lrrc49 in trigeminal ganglion contributes to neuropathic pain in mice by downregulating Ist1 and impairing autophagy. Tang Q, et al. J Neurochem, 2024 Jul. PMID 38348636
  2. Spg20-/- mice reveal multimodal functions for Troyer syndrome protein spartin in lipid droplet maintenance, cytokinesis and BMP signaling. Renvoisé B, et al. Hum Mol Genet, 2012 Aug 15. PMID 22619377, Free PMC Article
  3. Plasma membrane deformation by circular arrays of ESCRT-III protein filaments. Hanson PI, et al. J Cell Biol, 2008 Jan 28. PMID 18209100, Free PMC Article
  4. MAPT/Tau accumulation represses autophagy flux by disrupting IST1-regulated ESCRT-III complex formation: a vicious cycle in Alzheimer neurodegeneration. Feng Q, et al. Autophagy, 2020 Apr. PMID 31223056, Free PMC Article
  5. Identification of tooth-specific downstream targets of Runx2. Gaikwad JS, et al. Gene, 2001 Nov 14. PMID 11722849

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Reduced circ_lrrc49 in trigeminal ganglion contributes to neuropathic pain in mice by downregulating Ist1 and impairing autophagy.
    Title: Reduced circ_lrrc49 in trigeminal ganglion contributes to neuropathic pain in mice by downregulating Ist1 and impairing autophagy.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables MIT domain binding IEA
Inferred from Electronic Annotation
more info
  
enables MIT domain binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
  
enables protein-containing complex binding IEA
Inferred from Electronic Annotation
more info
  
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in abscission ISO
Inferred from Sequence Orthology
more info
  
involved_in cell division ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of collateral sprouting IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in cytoskeleton-dependent cytokinesis ISO
Inferred from Sequence Orthology
more info
  
involved_in establishment of protein localization ISO
Inferred from Sequence Orthology
more info
  
involved_in midbody abscission IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of collateral sprouting IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of proteolysis ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein localization ISO
Inferred from Sequence Orthology
more info
  
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in viral capsid secondary envelopment ISO
Inferred from Sequence Orthology
more info
  
involved_in viral release from host cell ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Flemming body IEA
Inferred from Electronic Annotation
more info
  
located_in Flemming body ISO
Inferred from Sequence Orthology
more info
  
located_in centrosome IEA
Inferred from Electronic Annotation
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in chromatin IEA
Inferred from Electronic Annotation
more info
  
located_in chromatin ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum-Golgi intermediate compartment IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum-Golgi intermediate compartment ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular exosome ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in midbody ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear envelope IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
IST1 homolog
Names
charged multivesicular body protein 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001361562.1 → NP_001348491.1  IST1 homolog isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame segment compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AC125162
    UniProtKB/TrEMBL
    Q8BHC2
    Conserved Domains (1) summary
    pfam03398
    Location:13 → 176
    Ist1; Regulator of Vps4 activity in the MVB pathway

  2. NM_028018.2 → NP_082294.1  IST1 homolog isoform 1

    See identical proteins and their annotated locations for NP_082294.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AK010262, BE947178, BY160969
    Consensus CDS
    CCDS22655.1
    UniProtKB/Swiss-Prot
    Q80U68, Q9CX00
    Related
    ENSMUSP00000034164.5, ENSMUST00000034164.6
    Conserved Domains (1) summary
    pfam03398
    Location:13 → 176
    Ist1; Regulator of Vps4 activity in the MVB pathway

RNA

  1. NR_155034.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains an alternate exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC125162

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    110397953..110419929 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036154300.1 → XP_036010193.1  IST1 homolog isoform X1

    Conserved Domains (1) summary
    pfam03398
    Location:20 → 166
    Ist1; Regulator of Vps4 activity in the MVB pathway

  2. XM_017312971.3 → XP_017168460.1  IST1 homolog isoform X2

    Conserved Domains (1) summary
    pfam03398
    Location:1 → 108
    Ist1; Regulator of Vps4 activity in the MVB pathway

RNA

  1. XR_003947337.2 RNA Sequence

    Related
    ENSMUST00000212973.2

  2. XR_001778470.2 RNA Sequence

  3. XR_001778468.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CX00.1 GenPept UniProtKB/Swiss-Prot:Q9CX00

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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