Sars2 seryl-aminoacyl-tRNA synthetase 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Sars2provided by MGI
Official Full Name: seryl-aminoacyl-tRNA synthetase 2provided by MGI
Primary source: MGI:MGI:1919234
See related: Ensembl:ENSMUSG00000070699 AllianceGenome:MGI:1919234
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: SerRS; SerRSmt; D7Ertd353e; 2410015F05Rik
Summary: Predicted to enable ATP binding activity; serine-tRNA ligase activity; and tRNA binding activity. Predicted to be involved in mitochondrial seryl-tRNA aminoacylation. Located in mitochondrion. Is expressed in several structures, including alimentary system; eye; integumental system; nervous system; and respiratory system. Orthologous to human SARS2 (seryl-tRNA synthetase 2, mitochondrial). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in thymus adult (RPKM 17.6), adrenal adult (RPKM 16.8) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 B1; 7 16.91 cM

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (28441393..28453304)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (28741957..28753879)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Identification of an array of 4 CCAAT box elements required for efficient transcription of the Sars2 gene.
Title: The bidirectional promoter of two genes for the mitochondrial translational apparatus in mouse is regulated by an array of CCAAT boxes interacting with the transcription factor NF-Y.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables serine-tRNA ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables serine-tRNA ligase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables tRNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in mitochondrial seryl-tRNA aminoacylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in seryl-tRNA aminoacylation	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial matrix	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	ISS Inferred from Sequence or Structural Similarity more info	PubMed

General protein information

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Preferred Names: serine--tRNA ligase, mitochondrial

Names: seryl-tRNA synthetase, mitochondrial; seryl-tRNA(Ser/Sec) synthetase

NP_076126.2

EC 6.1.1.11

XP_006540438.1

EC 6.1.1.11

XP_006540439.1

EC 6.1.1.11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_023637.3 → NP_076126.2 serine--tRNA ligase, mitochondrial precursor

See identical proteins and their annotated locations for NP_076126.2

Status: VALIDATED

Source sequence(s)

AK010491, BY649585, CX122368

Consensus CDS

CCDS21053.1

UniProtKB/Swiss-Prot

Q68FL2, Q9CWP1, Q9JJL8

Related

ENSMUSP00000092216.5, ENSMUST00000094632.6

Conserved Domains (3) summary

PRK05431
Location:67 → 493

PRK05431; seryl-tRNA synthetase; Provisional

cd00770
Location:185 → 485

SerRS_core; Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme bound ...

cl12057
Location:67 → 172

Seryl_tRNA_N; Seryl-tRNA synthetase N-terminal domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

28441393..28453304

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006540375.5 → XP_006540438.1 serine--tRNA ligase, mitochondrial isoform X1

Conserved Domains (1) summary

PRK05431
Location:67 → 253

PRK05431; seryl-tRNA synthetase; Provisional
XM_006540376.3 → XP_006540439.1 serine--tRNA ligase, mitochondrial isoform X2

Conserved Domains (1) summary

cl00268
Location:1 → 228

class_II_aaRS-like_core; Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches ...