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Cyp4f18 cytochrome P450, family 4, subfamily f, polypeptide 18 [ Mus musculus (house mouse) ]

Gene ID: 72054, updated on 27-Nov-2024

Summary

Official Symbol
Cyp4f18provided by MGI
Official Full Name
cytochrome P450, family 4, subfamily f, polypeptide 18provided by MGI
Primary source
MGI:MGI:1919304
See related
Ensembl:ENSMUSG00000003484 AllianceGenome:MGI:1919304
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cyp4f3; Cypf18; CYPIVF3; 1810054N16Rik
Summary
Enables long-chain fatty acid omega-1 hydroxylase activity. Involved in leukotriene B4 metabolic process. Predicted to be located in apical plasma membrane; cytoplasm; and intracellular membrane-bounded organelle. Orthologous to several human genes including CYP4F3 (cytochrome P450 family 4 subfamily F member 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in spleen adult (RPKM 31.6), mammary gland adult (RPKM 9.0) and 13 other tissues See more
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Genomic context

See Cyp4f18 in Genome Data Viewer
Location:
8 B3.3; 8 34.67 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (72742326..72763512, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (71988482..72009668, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E10511 Neighboring gene zinc finger protein 617 Neighboring gene STARR-positive B cell enhancer ABC_E3784 Neighboring gene STARR-seq mESC enhancer starr_21836 Neighboring gene zinc finger protein 961 Neighboring gene STARR-seq mESC enhancer starr_21837 Neighboring gene STARR-seq mESC enhancer starr_21838 Neighboring gene predicted gene, 51535 Neighboring gene predicted gene 45734 Neighboring gene gem (nuclear organelle) associated protein 8 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (2)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 20-aldehyde-leukotriene B4 20-monooxygenase activity ISO
Inferred from Sequence Orthology
more info
 
enables 20-hydroxy-leukotriene B4 omega oxidase activity ISO
Inferred from Sequence Orthology
more info
 
enables alkane 1-monooxygenase activity ISO
Inferred from Sequence Orthology
more info
 
enables alpha-tocopherol omega-hydroxylase activity ISO
Inferred from Sequence Orthology
more info
 
enables arachidonate epoxygenase activity ISO
Inferred from Sequence Orthology
more info
 
enables arachidonate monooxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables arachidonate omega-hydroxylase activity ISO
Inferred from Sequence Orthology
more info
 
enables heme binding IEA
Inferred from Electronic Annotation
more info
 
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
 
enables leukotriene-B4 20-monooxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables leukotriene-B4 20-monooxygenase activity ISO
Inferred from Sequence Orthology
more info
 
enables long-chain fatty acid omega-1 hydroxylase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables long-chain fatty acid omega-1 hydroxylase activity ISO
Inferred from Sequence Orthology
more info
 
enables long-chain fatty acid omega-hydroxylase activity ISO
Inferred from Sequence Orthology
more info
 
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen ISO
Inferred from Sequence Orthology
more info
 
enables very long-chain fatty acid omega-hydroxylase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in arachidonate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in leukotriene B4 catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in leukotriene B4 metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
cytochrome P450 4F3
Names
cytochrome P450 CYP4F18
cytochrome P450, 4f18
cytochrome P450-LTB-omega
leukotriene-B(4) 20-monooxygenase 2
leukotriene-B(4) omega-1/omega-2 hydroxylase
leukotriene-B(4) omega-hydroxylase 2
NP_077764.2
XP_006509811.1
XP_006509812.1
XP_011240629.1
XP_030099642.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_024444.2NP_077764.2  cytochrome P450 4F3

    See identical proteins and their annotated locations for NP_077764.2

    Status: VALIDATED

    Source sequence(s)
    AC162522, AK007863, BB804325
    Consensus CDS
    CCDS22406.1
    UniProtKB/Swiss-Prot
    E9QLZ3, Q99N16, Q9D8N4
    Related
    ENSMUSP00000003574.5, ENSMUST00000003574.5
    Conserved Domains (1) summary
    pfam00067
    Location:52516
    p450; Cytochrome P450

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    72742326..72763512 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011242327.3XP_011240629.1  cytochrome P450 4F3 isoform X2

    Conserved Domains (1) summary
    pfam00067
    Location:52381
    p450; Cytochrome P450
  2. XM_006509748.3XP_006509811.1  cytochrome P450 4F3 isoform X1

    See identical proteins and their annotated locations for XP_006509811.1

    UniProtKB/Swiss-Prot
    E9QLZ3, Q99N16, Q9D8N4
    Conserved Domains (1) summary
    pfam00067
    Location:52516
    p450; Cytochrome P450
  3. XM_006509749.5XP_006509812.1  cytochrome P450 4F3 isoform X3

    Conserved Domains (1) summary
    pfam00067
    Location:1379
    p450; Cytochrome P450
  4. XM_030243782.1XP_030099642.1  cytochrome P450 4F3 isoform X3

    Conserved Domains (1) summary
    pfam00067
    Location:1379
    p450; Cytochrome P450