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Ogfr opioid growth factor receptor [ Mus musculus (house mouse) ]

Gene ID: 72075, updated on 27-Nov-2024

Summary

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Official Symbol
Ogfrprovided by MGI
Official Full Name
opioid growth factor receptorprovided by MGI
Primary source
MGI:MGI:1919325
See related
Ensembl:ENSMUSG00000049401 AllianceGenome:MGI:1919325
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2010013E17Rik
Summary
Predicted to enable opioid growth factor receptor activity. Predicted to be located in cytoplasm; membrane; and nucleus. Is expressed in genitourinary system and metanephros. Orthologous to human OGFR (opioid growth factor receptor). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 34.2), CNS E14 (RPKM 28.8) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Ogfr in Genome Data Viewer
Location:
2 H4; 2 103.13 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (180231200..180237630)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (180589407..180595837)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene neurotensin receptor 1 Neighboring gene predicted gene, 30144 Neighboring gene STARR-positive B cell enhancer ABC_E9543 Neighboring gene STARR-positive B cell enhancer ABC_E4530 Neighboring gene MRG/MORF4L binding protein Neighboring gene collagen, type IX, alpha 3 Neighboring gene transcription factor-like 5 (basic helix-loop-helix) Neighboring gene predicted gene, 54097 Neighboring gene death inducer-obliterator 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Opioid growth factor receptor: Anatomical distribution and receptor colocalization in neurons of the adult mouse brain. Kareem ZY, et al. Neuropeptides, 2023 Jun. PMID 36812665
  2. Targeted overexpression of OGFr in epithelium of transgenic mice suppresses cell proliferation and impairs full-thickness wound closure. McLaughlin PJ, et al. Am J Physiol Regul Integr Comp Physiol, 2012 May. PMID 22338080
  3. Molecular characterization and distribution of the opioid growth factor receptor (OGFr) in mouse. Zagon IS, et al. Brain Res Mol Brain Res, 2000 Dec 8. PMID 11113537
  4. Temporal and spatial transcriptional programs in murine kidney development. Challen G, et al. Physiol Genomics, 2005 Oct 17. PMID 15998744
  5. The biology of the opioid growth factor receptor (OGFr). Zagon IS, et al. Brain Res Brain Res Rev, 2002 Feb. PMID 11890982

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Opioid growth factor receptor: Anatomical distribution and receptor colocalization in neurons of the adult mouse brain.
    Title: Opioid growth factor receptor: Anatomical distribution and receptor colocalization in neurons of the adult mouse brain.
  2. These data demonstrate for the first time that stable genetic amplification of OGFr downregulates homeostatic cell proliferation, as well as pathophysiological processes with respect to wound repair.
    Title: Targeted overexpression of OGFr in epithelium of transgenic mice suppresses cell proliferation and impairs full-thickness wound closure.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables opioid growth factor receptor activity IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
opioid growth factor receptor
Names
zeta-type opioid receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031373.3 → NP_113550.3  opioid growth factor receptor

    See identical proteins and their annotated locations for NP_113550.3

    Status: VALIDATED

    Source sequence(s)
    AF303894, CJ144579, CO040942
    Consensus CDS
    CCDS17179.1
    UniProtKB/Swiss-Prot
    A2ACT6, Q99L33, Q99PG2
    UniProtKB/TrEMBL
    Q80UU6
    Related
    ENSMUSP00000029087.4, ENSMUST00000029087.4
    Conserved Domains (3) summary
    PHA03169
    Location:284 → 548
    PHA03169; hypothetical protein; Provisional
    pfam04664
    Location:76 → 283
    OGFr_N; Opioid growth factor receptor (OGFr) conserved region
    pfam15231
    Location:472 → 620
    VCX_VCY; Variable charge X/Y family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    180231200..180237630
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017319269.3 → XP_017174758.1  opioid growth factor receptor isoform X1

    UniProtKB/TrEMBL
    Q80UU6
    Conserved Domains (3) summary
    PTZ00449
    Location:414 → 612
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    PHA03169
    Location:263 → 527
    PHA03169; hypothetical protein; Provisional
    pfam04664
    Location:55 → 262
    OGFr_N; Opioid growth factor receptor (OGFr) conserved region

  2. XM_036162586.1 → XP_036018479.1  opioid growth factor receptor isoform X2

    UniProtKB/TrEMBL
    Q80UU6
    Conserved Domains (2) summary
    PTZ00449
    Location:349 → 547
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    pfam04664
    Location:38 → 197
    OGFr_N; Opioid growth factor receptor (OGFr) conserved region
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99PG2.1 GenPept UniProtKB/Swiss-Prot:Q99PG2

Gene LinkOut

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