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Sh2d4a SH2 domain containing 4A [ Mus musculus (house mouse) ]

Gene ID: 72281, updated on 9-Dec-2024

Summary

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Official Symbol
Sh2d4aprovided by MGI
Official Full Name
SH2 domain containing 4Aprovided by MGI
Primary source
MGI:MGI:1919531
See related
Ensembl:ENSMUSG00000053886 AllianceGenome:MGI:1919531
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
SH2A; 2210402M20Rik
Summary
Predicted to enable phosphatase binding activity. Located in cytoplasm. Is expressed in medulla oblongata floor plate; metencephalon floor plate; and spinal cord floor plate. Orthologous to human SH2D4A (SH2 domain containing 4A). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Broad expression in bladder adult (RPKM 6.9), stomach adult (RPKM 6.8) and 22 other tissues See more
Orthologs
human all
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Genomic context

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See Sh2d4a in Genome Data Viewer
Location:
8 B3.3; 8 33.76 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (68729180..68800356)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (68276528..68347704)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene pleckstrin and Sec7 domain containing 3 Neighboring gene predicted gene, 53438 Neighboring gene predicted gene 15991 Neighboring gene STARR-seq mESC enhancer starr_21700 Neighboring gene predicted gene, 22018 Neighboring gene STARR-positive B cell enhancer mm9_chr8:70681079-70681379 Neighboring gene STARR-seq mESC enhancer starr_21702 Neighboring gene STARR-positive B cell enhancer mm9_chr8:70772052-70772353 Neighboring gene STARR-seq mESC enhancer starr_21703 Neighboring gene STARR-seq mESC enhancer starr_21704 Neighboring gene STARR-seq mESC enhancer starr_21705 Neighboring gene STARR-seq mESC enhancer starr_21706 Neighboring gene RIKEN cDNA 1700125H03 gene Neighboring gene chondroitin sulfate N-acetylgalactosaminyltransferase 1 Neighboring gene upstream binding transcription factor, RNA polymerase I-like 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_21708 Neighboring gene STARR-seq mESC enhancer starr_21710 Neighboring gene STARR-positive B cell enhancer mm9_chr8:71151041-71151341 Neighboring gene STARR-positive B cell enhancer ABC_E5009 Neighboring gene STARR-seq mESC enhancer starr_21711 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:71317593-71317892 Neighboring gene ribosomal protein 10 pseudogene Neighboring gene integrator complex subunit 10

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Genetic analysis of SH2D4A, a novel adapter protein related to T cell-specific adapter and adapter protein in lymphocytes of unknown function, reveals a redundant function in T cells. Lapinski PE, et al. J Immunol, 2008 Aug 1. PMID 18641339, Free PMC Article
  2. Expression and subcellular distribution of novel glomerulus-associated proteins dendrin, ehd3, sh2d4a, plekhh2, and 2310066E14Rik. Patrakka J, et al. J Am Soc Nephrol, 2007 Mar. PMID 17251388
  3. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  4. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
  5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SH2D4A is dispensable for TCR signal transduction in T cells
    Title: Genetic analysis of SH2D4A, a novel adapter protein related to T cell-specific adapter and adapter protein in lymphocytes of unknown function, reveals a redundant function in T cells.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables phosphatase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatase binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatase binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
SH2 domain-containing protein 4A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_028182.1 → NP_082458.1  SH2 domain-containing protein 4A

    See identical proteins and their annotated locations for NP_082458.1

    Status: VALIDATED

    Source sequence(s)
    AC117740, AC117792, AK008803
    Consensus CDS
    CCDS52564.1
    UniProtKB/Swiss-Prot
    Q14AV2, Q9D7V1
    UniProtKB/TrEMBL
    A0A1D5RMA9
    Related
    ENSMUSP00000070825.4, ENSMUST00000066594.4
    Conserved Domains (2) summary
    PTZ00121
    Location:32 → 242
    PTZ00121; MAEBL; Provisional
    cd10350
    Location:307 → 409
    SH2_SH2D4A; Src homology 2 domain found in the SH2 domain containing protein 4A (SH2D4A)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    68729180..68800356
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006509751.4 → XP_006509814.1  SH2 domain-containing protein 4A isoform X1

    See identical proteins and their annotated locations for XP_006509814.1

    UniProtKB/Swiss-Prot
    Q14AV2, Q9D7V1
    UniProtKB/TrEMBL
    A0A1D5RMA9
    Related
    ENSMUSP00000148702.2, ENSMUST00000212166.2
    Conserved Domains (2) summary
    PTZ00121
    Location:32 → 242
    PTZ00121; MAEBL; Provisional
    cd10350
    Location:307 → 409
    SH2_SH2D4A; Src homology 2 domain found in the SH2 domain containing protein 4A (SH2D4A)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D7V1.1 GenPept UniProtKB/Swiss-Prot:Q9D7V1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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