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Taf4b TATA-box binding protein associated factor 4b [ Mus musculus (house mouse) ]

Gene ID: 72504, updated on 27-Nov-2024

Summary

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Official Symbol
Taf4bprovided by MGI
Official Full Name
TATA-box binding protein associated factor 4bprovided by MGI
Primary source
MGI:MGI:2152345
See related
Ensembl:ENSMUSG00000054321 AllianceGenome:MGI:2152345
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
105kDa; Taf2c2; TAFII105; TAFII-105; 2610524B04Rik; 4932409F03Rik
Summary
Predicted to enable DNA binding activity and NF-kappaB binding activity. Predicted to contribute to RNA polymerase II general transcription initiation factor activity. Involved in positive regulation of stem cell proliferation. Predicted to be located in fibrillar center and nucleoplasm. Predicted to be part of transcription factor TFIID complex. Is expressed in genitourinary system and tail. Human ortholog(s) of this gene implicated in spermatogenic failure 13. Orthologous to human TAF4B (TATA-box binding protein associated factor 4b). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in ovary adult (RPKM 3.7), testis adult (RPKM 2.9) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Taf4b in Genome Data Viewer
Location:
18 A1; 18 8.28 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (14916302..15035160)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (14783201..14960424)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene SS18, subunit of BAF chromatin remodeling complex Neighboring gene predicted gene, 24924 Neighboring gene STARR-seq mESC enhancer starr_43875 Neighboring gene STARR-seq mESC enhancer starr_43877 Neighboring gene proteasome subunit alpha 8 Neighboring gene STARR-positive B cell enhancer ABC_E1951 Neighboring gene non-POU-domain-containing, octamer binding protein pseudogene Neighboring gene STARR-seq mESC enhancer starr_43878 Neighboring gene RIKEN cDNA 4930543D07 gene Neighboring gene SUMO/sentrin specific peptidase 5 pseudogene Neighboring gene predicted gene, 54035

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Redundant role of tissue-selective TAF(II)105 in B lymphocytes. Freiman RN, et al. Mol Cell Biol, 2002 Sep. PMID 12192054, Free PMC Article
  2. Dynamic and regulated TAF gene expression during mouse embryonic germ cell development. Gura MA, et al. PLoS Genet, 2020 Jan. PMID 31914128, Free PMC Article
  3. TAF4b, a TBP associated factor, is required for oocyte development and function. Falender AE, et al. Dev Biol, 2005 Dec 15. PMID 16289522
  4. Ovarian granulosa cell survival and proliferation requires the gonad-selective TFIID subunit TAF4b. Voronina E, et al. Dev Biol, 2007 Mar 15. PMID 17207475, Free PMC Article
  5. Enhanced apoptosis of B and T lymphocytes in TAFII105 dominant-negative transgenic mice is linked to nuclear factor-kappa B. Silkov A, et al. J Biol Chem, 2002 May 17. PMID 11856754

See all (42) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TAF4b transcription networks regulating early oocyte differentiation.
    Title: TAF4b transcription networks regulating early oocyte differentiation.
  2. Taf4b mRNA and protein expression is differentially regulated during embryonic germ cell development.
    Title: Dynamic and regulated TAF gene expression during mouse embryonic germ cell development.
  3. TAF4b-deficient spermatogenic progenitor cells display a tendency for differentiation at the expense of self-renewal.
    Title: TAF4b is required for mouse spermatogonial stem cell development.
  4. Data show that the TFIID subunit TAF4 is essential to restrain the growth promoting properties of collagen 6A3 (Col6a3).
    Title: TAF4 inactivation reveals the 3 dimensional growth promoting activities of collagen 6A3.
  5. These data reveal a novel TAF4b function in orchestrating the correct timing of germ cell cyst breakdown and establishment of the primordial follicle reserve during a critical window of development.
    Title: TAF4b promotes mouse primordial follicle assembly and oocyte survival.
  6. These data highlight the novel response of the general transcription factor TAF4B to estrogen in the normal ovary and during ovarian tumor progression in the mouse.
    Title: Estrogen responsiveness of the TFIID subunit TAF4B in the normal mouse ovary and in ovarian tumors.
  7. Taf4b binds Oct4 in vitro and cooperates to regulate a subset of genes in embryonic stem cells.
    Title: TAF4b and TAF4 differentially regulate mouse embryonic stem cells maintenance and proliferation.
  8. Small interfering RNA knockdown of Taf4b results in decreased cell proliferation and altered osteogenic differentiation in primary mouse embryonic maxillary mesenchymal cells.
    Title: Transforming growth factor-beta regulates basal transcriptional regulatory machinery to control cell proliferation and differentiation in cranial neural crest-derived osteoprogenitor cells.
  9. linked to the posttranscriptional control of ovarian gene expression
    Title: Accelerated ovarian aging in the absence of the transcription regulator TAF4B in mice.
  10. role of TAF(II)105 in B lymphocytes
    Title: Redundant role of tissue-selective TAF(II)105 in B lymphocytes.
Submit: New GeneRIF Correction See all GeneRIFs (14)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (1)  1 citation

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables NF-kappaB binding ISO
Inferred from Sequence Orthology
more info
  
contributes_to RNA polymerase II general transcription initiation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in RNA polymerase II preinitiation complex assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in mRNA transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in mRNA transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in oogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of stem cell proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription initiation by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription initiation by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within regulation of transcription by RNA polymerase II TAS
Traceable Author Statement
more info
 PubMed 
involved_in spermatogenesis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within transcription by RNA polymerase II TAS
Traceable Author Statement
more info
 PubMed 
involved_in transcription initiation at RNA polymerase II promoter IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in fibrillar center ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of transcription factor TFIID complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of transcription factor TFIID complex ISO
Inferred from Sequence Orthology
more info
  
part_of transcription factor TFIID complex ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of transcription regulator complex TAS
Traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
transcription initiation factor TFIID subunit 4B
Names
TAF(II)105
TAF4B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105 kDa
TATA box binding protein (TBP)-associated factor, RNA polymerase II, C2, 105kD
transcription initiation factor TFIID 105 kDa subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001100449.2 → NP_001093919.1  transcription initiation factor TFIID subunit 4B isoform 1

    See identical proteins and their annotated locations for NP_001093919.1

    Status: VALIDATED

    Source sequence(s)
    AC102692, AC125091, AC133172
    Consensus CDS
    CCDS50227.1
    UniProtKB/Swiss-Prot
    G5E8Z2
    UniProtKB/TrEMBL
    A0A3B2W725
    Related
    ENSMUSP00000126909.2, ENSMUST00000169862.2
    Conserved Domains (2) summary
    pfam05236
    Location:610 → 850
    TAF4; Transcription initiation factor TFIID component TAF4 family
    pfam07531
    Location:257 → 343
    TAFH; NHR1 homology to TAF

  2. NM_001369357.1 → NP_001356286.1  transcription initiation factor TFIID subunit 4B isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC102692, AC125091, AC133172
    Consensus CDS
    CCDS89195.1
    UniProtKB/Swiss-Prot
    G5E8Z2
    UniProtKB/TrEMBL
    A0A3Q4EGS4
    Related
    ENSMUSP00000157354.2, ENSMUST00000234789.2
    Conserved Domains (3) summary
    PRK14950
    Location:2 → 91
    PRK14950; DNA polymerase III subunits gamma and tau; Provisional
    pfam05236
    Location:605 → 845
    TAF4; Transcription initiation factor TFIID component TAF4 family
    pfam07531
    Location:257 → 343
    TAFH; NHR1 homology to TAF

  3. NM_001369358.1 → NP_001356287.1  transcription initiation factor TFIID subunit 4B isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC102692, AC125091, AC133172
    UniProtKB/Swiss-Prot
    G5E8Z2
    Conserved Domains (4) summary
    COG5665
    Location:137 → 318
    COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]
    PRK14950
    Location:2 → 91
    PRK14950; DNA polymerase III subunits gamma and tau; Provisional
    pfam05236
    Location:564 → 804
    TAF4; Transcription initiation factor TFIID component TAF4 family
    cl02658
    Location:253 → 302
    TAFH; NHR1 homology to TAF

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    14916302..15035160
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
G5E8Z2.2 GenPept UniProtKB/Swiss-Prot:G5E8Z2

Gene LinkOut

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